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Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells

View ORCID ProfileSameer S. Chopra, Anne Jenney, Adam Palmer, Mario Niepel, Mirra Chung, Caitlin Mills, Sindhu Carmen Sivakumaren, Qingsong Liu, Jia-Yun Chen, Clarence Yapp, John M. Asara, Nathanael S. Gray, Peter K. Sorger
doi: https://doi.org/10.1101/700625
Sameer S. Chopra
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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  • ORCID record for Sameer S. Chopra
Anne Jenney
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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Adam Palmer
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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Mario Niepel
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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Mirra Chung
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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Caitlin Mills
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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Sindhu Carmen Sivakumaren
2Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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Qingsong Liu
2Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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Jia-Yun Chen
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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Clarence Yapp
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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John M. Asara
4Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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Nathanael S. Gray
2Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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Peter K. Sorger
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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  • For correspondence: Peter_Sorger@hms.harvard.edu
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Posted July 12, 2019.
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Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells
Sameer S. Chopra, Anne Jenney, Adam Palmer, Mario Niepel, Mirra Chung, Caitlin Mills, Sindhu Carmen Sivakumaren, Qingsong Liu, Jia-Yun Chen, Clarence Yapp, John M. Asara, Nathanael S. Gray, Peter K. Sorger
bioRxiv 700625; doi: https://doi.org/10.1101/700625
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Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells
Sameer S. Chopra, Anne Jenney, Adam Palmer, Mario Niepel, Mirra Chung, Caitlin Mills, Sindhu Carmen Sivakumaren, Qingsong Liu, Jia-Yun Chen, Clarence Yapp, John M. Asara, Nathanael S. Gray, Peter K. Sorger
bioRxiv 700625; doi: https://doi.org/10.1101/700625

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