Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells

Sameer S. Chopra; Anne Jenney; Adam Palmer; Mario Niepel; Mirra Chung; Caitlin Mills; Sindhu Carmen Sivakumaren; Qingsong Liu; Jia-Yun Chen; Clarence Yapp; John M. Asara; Nathanael S. Gray; Peter K. Sorger

doi:10.1101/700625

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Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells

View ORCID ProfileSameer S. Chopra, Anne Jenney, Adam Palmer, Mario Niepel, Mirra Chung, Caitlin Mills, Sindhu Carmen Sivakumaren, Qingsong Liu, Jia-Yun Chen, Clarence Yapp, John M. Asara, Nathanael S. Gray, Peter K. Sorger

doi: https://doi.org/10.1101/700625

Sameer S. Chopra

1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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ORCID record for Sameer S. Chopra

Anne Jenney

1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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Adam Palmer

1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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Mario Niepel

1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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Mirra Chung

1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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Caitlin Mills

1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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Sindhu Carmen Sivakumaren

2Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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Qingsong Liu

2Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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Jia-Yun Chen

1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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Clarence Yapp

1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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John M. Asara

4Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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Nathanael S. Gray

2Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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Peter K. Sorger

1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215

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For correspondence: Peter_Sorger@hms.harvard.edu

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Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells

Sameer S. Chopra, Anne Jenney, Adam Palmer, Mario Niepel, Mirra Chung, Caitlin Mills, Sindhu Carmen Sivakumaren, Qingsong Liu, Jia-Yun Chen, Clarence Yapp, John M. Asara, Nathanael S. Gray, Peter K. Sorger

bioRxiv 700625; doi: https://doi.org/10.1101/700625

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Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells

bioRxiv 700625; doi: https://doi.org/10.1101/700625

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