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Oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis increases expression of type I/III interferon-stimulated factors in the gastrointestinal tract but not in the blood
View ORCID ProfileSean M. Hughes, View ORCID ProfileClaire N. Levy, Fernanda Calienes, Joanne D. Stekler, View ORCID ProfileUrvashi Pandey, View ORCID ProfileLucia Vojtech, View ORCID ProfileAlicia R. Berard, Kenzie Birse, Laura Noel-Romas, View ORCID ProfileBrian Richardson, View ORCID ProfileJackelyn B. Golden, Michael Cartwright, Ann C. Collier, Claire E. Stevens, Marcel E. Curlin, View ORCID ProfileTimothy H. Holtz, Nelly Mugo, View ORCID ProfileElizabeth Irungu, View ORCID ProfileElly Katabira, View ORCID ProfileTimothy Muwonge, View ORCID ProfileJavier R. Lama, Jared M. Baeten, View ORCID ProfileAdam Burgener, Jairam R. Lingappa, View ORCID ProfileM. Juliana McElrath, Romel Mackelprang, Ian McGowan, View ORCID ProfileRoss D. Cranston, View ORCID ProfileMark J. Cameron, View ORCID ProfileFlorian Hladik
doi: https://doi.org/10.1101/701961
Sean M. Hughes
1Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America
Claire N. Levy
1Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America
Fernanda Calienes
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Joanne D. Stekler
3Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
15Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
17Department of Global Health, University of Washington, Seattle, Washington, United States of America
Urvashi Pandey
1Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America
Lucia Vojtech
1Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America
Alicia R. Berard
4National HIV and Retrovirology Labs, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
5Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
Kenzie Birse
4National HIV and Retrovirology Labs, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
5Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
Laura Noel-Romas
4National HIV and Retrovirology Labs, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
5Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
Brian Richardson
6Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
Jackelyn B. Golden
6Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
Michael Cartwright
6Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
Ann C. Collier
15Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
Claire E. Stevens
15Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
Marcel E. Curlin
7Thailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand
8Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
9Department of Medicine, Division of Infectious Diseases, Oregon Health and Sciences University, Portland, Oregon, United States of America
Timothy H. Holtz
7Thailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand
8Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Nelly Mugo
10Partners in Health Research and Development, Kenya Medical Research Institute, Thika, Kenya
Elizabeth Irungu
10Partners in Health Research and Development, Kenya Medical Research Institute, Thika, Kenya
Elly Katabira
11Infectious Disease Institute, Makerere University, Kampala, Uganda
Timothy Muwonge
11Infectious Disease Institute, Makerere University, Kampala, Uganda
Javier R. Lama
12Asociación Civil Impacta Salud y Educación, Lima, Peru
Jared M. Baeten
3Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
15Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
17Department of Global Health, University of Washington, Seattle, Washington, United States of America
Adam Burgener
4National HIV and Retrovirology Labs, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
5Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
13Unit of Infectious Diseases, Department of Medicine Solna, Centre for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Jairam R. Lingappa
14Department of Pediatrics, University of Washington, Seattle, Washington, United States of America
15Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
17Department of Global Health, University of Washington, Seattle, Washington, United States of America
M. Juliana McElrath
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
15Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
16Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America
17Department of Global Health, University of Washington, Seattle, Washington, United States of America
Romel Mackelprang
17Department of Global Health, University of Washington, Seattle, Washington, United States of America
Ian McGowan
18Magee-Womens Research Institute and Foundation, Pittsburgh, Pennsylvania, United States of America
19Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Ross D. Cranston
20Department of Infectious Diseases and Dermatology, University of Barcelona, Barcelona, Spain
Mark J. Cameron
6Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
Florian Hladik
1Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
15Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
Article usage
Posted November 07, 2019.
Oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis increases expression of type I/III interferon-stimulated factors in the gastrointestinal tract but not in the blood
Sean M. Hughes, Claire N. Levy, Fernanda Calienes, Joanne D. Stekler, Urvashi Pandey, Lucia Vojtech, Alicia R. Berard, Kenzie Birse, Laura Noel-Romas, Brian Richardson, Jackelyn B. Golden, Michael Cartwright, Ann C. Collier, Claire E. Stevens, Marcel E. Curlin, Timothy H. Holtz, Nelly Mugo, Elizabeth Irungu, Elly Katabira, Timothy Muwonge, Javier R. Lama, Jared M. Baeten, Adam Burgener, Jairam R. Lingappa, M. Juliana McElrath, Romel Mackelprang, Ian McGowan, Ross D. Cranston, Mark J. Cameron, Florian Hladik
bioRxiv 701961; doi: https://doi.org/10.1101/701961
Oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis increases expression of type I/III interferon-stimulated factors in the gastrointestinal tract but not in the blood
Sean M. Hughes, Claire N. Levy, Fernanda Calienes, Joanne D. Stekler, Urvashi Pandey, Lucia Vojtech, Alicia R. Berard, Kenzie Birse, Laura Noel-Romas, Brian Richardson, Jackelyn B. Golden, Michael Cartwright, Ann C. Collier, Claire E. Stevens, Marcel E. Curlin, Timothy H. Holtz, Nelly Mugo, Elizabeth Irungu, Elly Katabira, Timothy Muwonge, Javier R. Lama, Jared M. Baeten, Adam Burgener, Jairam R. Lingappa, M. Juliana McElrath, Romel Mackelprang, Ian McGowan, Ross D. Cranston, Mark J. Cameron, Florian Hladik
bioRxiv 701961; doi: https://doi.org/10.1101/701961
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