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Consolidation of reward memory during sleep does not require dopaminergic activation

M Alizadeh Asfestani, V Brechtmann, J Santiago, J Born, GB Feld
doi: https://doi.org/10.1101/703132
M Alizadeh Asfestani
1Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, Germany
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V Brechtmann
1Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, Germany
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J Santiago
1Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, Germany
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J Born
1Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, Germany
2Center for Integrative Neuroscience, University of Tübingen, Tübingen, Germany
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GB Feld
1Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, Germany
3Clinical Psychology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
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  • For correspondence: gordon.feld@zi-mannheim.de jan.born@uni-tuebingen.de
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Abstract

Sleep enhances memories, especially, if they are related to future rewards. Although dopamine has been shown to be a key determinant during reward learning, the role of dopaminergic neurotransmission for amplifying reward-related memories during sleep remains unclear. In the present study, we scrutinize the idea that dopamine is needed for the preferential consolidation of rewarded information. We blocked dopaminergic neurotransmission, thereby aiming to wipe out preferential sleep-dependent consolidation of high over low rewarded memories during sleep. Following a double-blind, balanced, crossover design 20 young healthy men received the dopamine d2-like receptor blocker Sulpiride (800 mg) or placebo, after learning a Motivated Learning Task. The task required participants to memorize 80 highly and 80 lowly rewarded pictures. Half of them were presented for a short (750 ms) and a long duration (1500 ms), respectively, which enabled to dissociate effects of reward on sleep-associated consolidation from those of mere encoding depth. Retrieval was tested after a retention interval of 20 h that included 8 h of nocturnal sleep. As expected, at retrieval, highly rewarded memories were remembered better than lowly rewarded memories, under placebo. However, there was no evidence for an effect of blocking dopaminergic neurotransmission with Sulpiride during sleep on this differential retention of rewarded information. This result indicates that dopaminergic activation is not required for the preferential consolidation of reward-associated memory. Rather it appears that dopaminergic activation only tags such memories at encoding for intensified reprocessing during sleep.

Footnotes

  • Gordon Feld, Central Institute for Mental Health, J5, 68159 Mannheim, Germany, Tel. +49 621 1703 6540, Fax +49 621 1703 6505.

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Posted July 16, 2019.
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Consolidation of reward memory during sleep does not require dopaminergic activation
M Alizadeh Asfestani, V Brechtmann, J Santiago, J Born, GB Feld
bioRxiv 703132; doi: https://doi.org/10.1101/703132
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Consolidation of reward memory during sleep does not require dopaminergic activation
M Alizadeh Asfestani, V Brechtmann, J Santiago, J Born, GB Feld
bioRxiv 703132; doi: https://doi.org/10.1101/703132

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