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The ARRIVE guidelines 2019: updated guidelines for reporting animal research

View ORCID ProfileNathalie Percie du Sert, Viki Hurst, View ORCID ProfileAmrita Ahluwalia, View ORCID ProfileSabina Alam, View ORCID ProfileMarc T. Avey, Monya Baker, View ORCID ProfileWilliam J. Browne, Alejandra Clark, View ORCID ProfileInnes C. Cuthill, View ORCID ProfileUlrich Dirnagl, Michael Emerson, View ORCID ProfilePaul Garner, Stephen T. Holgate, View ORCID ProfileDavid W. Howells, View ORCID ProfileNatasha A. Karp, Katie Lidster, Catriona J. MacCallum, View ORCID ProfileMalcolm Macleod, Ole Petersen, View ORCID ProfileFrances Rawle, View ORCID ProfilePenny Reynolds, Kieron Rooney, Emily S. Sena, Shai D. Silberberg, View ORCID ProfileThomas Steckler, View ORCID ProfileHanno Würbel
doi: https://doi.org/10.1101/703181
Nathalie Percie du Sert
1NC3Rs, UK
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  • For correspondence: nathalie.perciedusert@nc3rs.org.uk
Viki Hurst
1NC3Rs, UK
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Amrita Ahluwalia
2Queen Mary University of London, UK
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Sabina Alam
3Taylor & Francis Group, UK
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Marc T. Avey
4ICF, USA
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Monya Baker
5Nature, USA
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William J. Browne
6University of Bristol, UK
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Alejandra Clark
7PLOS ONE, UK
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Innes C. Cuthill
6University of Bristol, UK
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Ulrich Dirnagl
8Universitätsmedizin Berlin, Germany
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Michael Emerson
9Imperial College London, UK
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Paul Garner
10Liverpool School of Tropical Medicine, UK
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Stephen T. Holgate
11University of Southampton, UK
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David W. Howells
12University of Tasmania, Australia
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Natasha A. Karp
13Data Sciences & Quantitative Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK
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Katie Lidster
1NC3Rs, UK
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Catriona J. MacCallum
14Hindawi Ltd, UK
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Malcolm Macleod
15Centre for Clinical Brain Sciences, University of Edinburgh, UK
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Ole Petersen
16Cardiff University, UK
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Frances Rawle
17Medical Research Council, UK
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Penny Reynolds
18University of Florida, USA
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Kieron Rooney
19University of Sydney, Australia
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Emily S. Sena
15Centre for Clinical Brain Sciences, University of Edinburgh, UK
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Shai D. Silberberg
20National Institute of Neurological Disorders and Stroke, USA
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Thomas Steckler
21Janssen Pharmaceutica NV, Belgium
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Hanno Würbel
22University of Bern, Switzerland
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Abstract

Reproducible science requires transparent reporting. The ARRIVE guidelines were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved.

Here we introduce ARRIVE 2019. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise the items and split the guidelines into two sets, the ARRIVE Essential 10, which constitute the minimum requirement, and the Recommended Set, which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers to verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration document that serves 1) to explain the rationale behind each item in the guidelines, 2) to clarify key concepts and 3) to provide illustrative examples. We aim through these changes to help ensure that researchers, reviewers and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.
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Posted July 15, 2019.
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The ARRIVE guidelines 2019: updated guidelines for reporting animal research
Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W. Howells, Natasha A. Karp, Katie Lidster, Catriona J. MacCallum, Malcolm Macleod, Ole Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S. Sena, Shai D. Silberberg, Thomas Steckler, Hanno Würbel
bioRxiv 703181; doi: https://doi.org/10.1101/703181
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The ARRIVE guidelines 2019: updated guidelines for reporting animal research
Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W. Howells, Natasha A. Karp, Katie Lidster, Catriona J. MacCallum, Malcolm Macleod, Ole Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S. Sena, Shai D. Silberberg, Thomas Steckler, Hanno Würbel
bioRxiv 703181; doi: https://doi.org/10.1101/703181

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