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PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

Mélissa Léveillé, Aurèle Besse-Patin, Nathalie Jouvet, Stewart Jeromson, Naveen P. Khan, Sarah Sczelecki, Cindy Baldwin, Annie Dumouchel, Jorge Correia, Paulo Jannig, Stephanie K. Petrillo, Anthoula Lazaris, Jonathan Boulais, Peter Metrakos, Jorge L. Ruas, View ORCID ProfileJennifer L. Estall
doi: https://doi.org/10.1101/703678
Mélissa Léveillé
1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
2Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
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Aurèle Besse-Patin
1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
2Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
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Nathalie Jouvet
1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
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Stewart Jeromson
1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
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Naveen P. Khan
1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
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Sarah Sczelecki
1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
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Cindy Baldwin
1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
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Annie Dumouchel
1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
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Jorge Correia
5Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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Paulo Jannig
5Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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Stephanie K. Petrillo
4Cancer Research Program, Department of Surgery, McGill University Health Center-Research Institute, Montreal, Quebec, H4A 3J1, Canada
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Anthoula Lazaris
4Cancer Research Program, Department of Surgery, McGill University Health Center-Research Institute, Montreal, Quebec, H4A 3J1, Canada
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Jonathan Boulais
1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
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Peter Metrakos
4Cancer Research Program, Department of Surgery, McGill University Health Center-Research Institute, Montreal, Quebec, H4A 3J1, Canada
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Jorge L. Ruas
5Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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Jennifer L. Estall
1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
2Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
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  • ORCID record for Jennifer L. Estall
  • For correspondence: jennifer.estall@ircm.qc.ca
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Article Information

doi 
https://doi.org/10.1101/703678
History 
  • July 16, 2019.

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  • You are currently viewing Version 1 of this article (July 16, 2019 - 08:38).
  • Version 2 (September 14, 2019 - 15:05).
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Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Mélissa Léveillé1,2,*,
  2. Aurèle Besse-Patin1,2,*,
  3. Nathalie Jouvet1,
  4. Stewart Jeromson1,3,
  5. Naveen P. Khan1,3,
  6. Sarah Sczelecki1,3,
  7. Cindy Baldwin1,
  8. Annie Dumouchel1,
  9. Jorge Correia5,
  10. Paulo Jannig5,
  11. Stephanie K. Petrillo4,
  12. Anthoula Lazaris4,
  13. Jonathan Boulais1,
  14. Peter Metrakos4,
  15. Jorge L. Ruas5 and
  16. Jennifer L. Estall1,2,3,¶
  1. 1Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada
  2. 2Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
  3. 3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
  4. 4Cancer Research Program, Department of Surgery, McGill University Health Center-Research Institute, Montreal, Quebec, H4A 3J1, Canada
  5. 5Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
  1. ↵¶Corresponding author: Jennifer L. Estall, IRCM, 110 avenue des Pins Ouest, Montreal, Quebec, H2W 1R7 Canada. Phone: 514 987 5688, Email: jennifer.estall{at}ircm.qc.ca
  1. ↵* denotes equal contribution

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PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
Mélissa Léveillé, Aurèle Besse-Patin, Nathalie Jouvet, Stewart Jeromson, Naveen P. Khan, Sarah Sczelecki, Cindy Baldwin, Annie Dumouchel, Jorge Correia, Paulo Jannig, Stephanie K. Petrillo, Anthoula Lazaris, Jonathan Boulais, Peter Metrakos, Jorge L. Ruas, Jennifer L. Estall
bioRxiv 703678; doi: https://doi.org/10.1101/703678
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PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
Mélissa Léveillé, Aurèle Besse-Patin, Nathalie Jouvet, Stewart Jeromson, Naveen P. Khan, Sarah Sczelecki, Cindy Baldwin, Annie Dumouchel, Jorge Correia, Paulo Jannig, Stephanie K. Petrillo, Anthoula Lazaris, Jonathan Boulais, Peter Metrakos, Jorge L. Ruas, Jennifer L. Estall
bioRxiv 703678; doi: https://doi.org/10.1101/703678

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