Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Striatal activity reflects cortical activity patterns

View ORCID ProfileAndrew J Peters, View ORCID ProfileNicholas A Steinmetz, View ORCID ProfileKenneth D Harris, View ORCID ProfileMatteo Carandini
doi: https://doi.org/10.1101/703710
Andrew J Peters
UCL Institute of Ophthalmology, University College London, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Andrew J Peters
Nicholas A Steinmetz
UCL Institute of Ophthalmology, University College London, London, UKUCL Queen Square Institute of Neurology, University College London, London, UKDepartment of Biological Structure, University of Washington, Seattle, WA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nicholas A Steinmetz
Kenneth D Harris
UCL Queen Square Institute of Neurology, University College London, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kenneth D Harris
Matteo Carandini
UCL Institute of Ophthalmology, University College London, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Matteo Carandini
  • For correspondence: m.carandini@ucl.ac.uk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

The dorsal striatum is organized into domains that drive characteristic behaviors1–7, and receive inputs from different parts of the cortex8,9 which modulate similar behaviors10–12. Striatal responses to cortical inputs, however, can be affected by changes in connection strength13–15, local striatal circuitry16,17, and thalamic inputs18,19. Therefore, it is unclear whether the pattern of activity across striatal domains mirrors that across the cortex20–23 or differs from it24–28. Here we use simultaneous large-scale recordings in the cortex and the striatum to show that striatal activity can be accurately predicted by spatiotemporal activity patterns in the cortex. The relationship between activity in the cortex and the striatum was spatially consistent with corticostriatal anatomy, and temporally consistent with a feedforward drive. Each striatal domain exhibited specific sensorimotor responses that predictably followed activity in the associated cortical regions, and the corticostriatal relationship remained unvaried during passive states or performance of a task probing visually guided behavior. However, the task’s visual stimuli and corresponding behavioral responses evoked relatively more activity in the striatum than in associated cortical regions. This increased striatal activity involved an additive offset in firing rate, which was independent of task engagement but only present in animals that had learned the task. Thus, striatal activity largely reflects patterns of cortical activity, deviating from them in a simple additive fashion for learned stimuli or actions.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted July 16, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Striatal activity reflects cortical activity patterns
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Striatal activity reflects cortical activity patterns
Andrew J Peters, Nicholas A Steinmetz, Kenneth D Harris, Matteo Carandini
bioRxiv 703710; doi: https://doi.org/10.1101/703710
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Striatal activity reflects cortical activity patterns
Andrew J Peters, Nicholas A Steinmetz, Kenneth D Harris, Matteo Carandini
bioRxiv 703710; doi: https://doi.org/10.1101/703710

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (1647)
  • Biochemistry (2739)
  • Bioengineering (1907)
  • Bioinformatics (10243)
  • Biophysics (4183)
  • Cancer Biology (3218)
  • Cell Biology (4538)
  • Clinical Trials (135)
  • Developmental Biology (2840)
  • Ecology (4460)
  • Epidemiology (2041)
  • Evolutionary Biology (7231)
  • Genetics (5476)
  • Genomics (6813)
  • Immunology (2388)
  • Microbiology (7483)
  • Molecular Biology (2992)
  • Neuroscience (18584)
  • Paleontology (136)
  • Pathology (472)
  • Pharmacology and Toxicology (780)
  • Physiology (1149)
  • Plant Biology (2706)
  • Scientific Communication and Education (680)
  • Synthetic Biology (888)
  • Systems Biology (2846)
  • Zoology (468)