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Short-term oxaliplatin exposure according to established hyperthermic intraperitoneal chemotherapy (HIPEC) protocols lacks effectiveness in vitro and ex vivo
View ORCID ProfileMarkus W. Löffler, Nick Seyfried, Markus Burkard, Benedikt Oswald, Alexander Tolios, Can Yurttas, Franziska Herster, Joseph Kauer, Tarkan Jäger, Karolin Thiel, Sebastian P. Haen, Hans-Georg Rammensee, Sascha Venturelli, Matthias Schwab, Alfred Königsrainer, Stefan Beckert
doi: https://doi.org/10.1101/709055
Markus W. Löffler
1University Hospital Tübingen, Department of General, Visceral and Transplant Surgery, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany
2Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, D-72076 Tübingen, Germany
3German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) partner site Tübingen, D-72076 Tübingen, Germany
4University Hospital Tübingen, Department of Clinical Pharmacology, Auf der Morgenstelle 8, D-72076 Tübingen, Germany
Nick Seyfried
1University Hospital Tübingen, Department of General, Visceral and Transplant Surgery, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany
2Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, D-72076 Tübingen, Germany
Markus Burkard
5University Hospital Tübingen, Institute of Physiology, Department of Vegetative and Clinical Physiology, Wilhelmstr. 56, 72074 Tübingen, Germany
Benedikt Oswald
2Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, D-72076 Tübingen, Germany
Alexander Tolios
6Medical University of Vienna, Department for Blood Group Serology and Transfusion Medicine, Währinger Gürtel 18-20, 1090 Vienna, Austria
Can Yurttas
1University Hospital Tübingen, Department of General, Visceral and Transplant Surgery, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany
Franziska Herster
2Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, D-72076 Tübingen, Germany
Joseph Kauer
2Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, D-72076 Tübingen, Germany
3German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) partner site Tübingen, D-72076 Tübingen, Germany
Tarkan Jäger
7Paracelsus Medical University, Department of Surgery, Müllner Hauptstraße 48, 5020 Salzburg, Austria
Karolin Thiel
1University Hospital Tübingen, Department of General, Visceral and Transplant Surgery, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany
Sebastian P. Haen
2Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, D-72076 Tübingen, Germany
3German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) partner site Tübingen, D-72076 Tübingen, Germany
8University Hospital Tübingen, Internal Medicine, Department for Oncology, Hematology, Immunology and Rheumatology, Otfried-Müller-Str. 10, 72076 Tübingen, Germany
Hans-Georg Rammensee
2Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, D-72076 Tübingen, Germany
3German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) partner site Tübingen, D-72076 Tübingen, Germany
Sascha Venturelli
5University Hospital Tübingen, Institute of Physiology, Department of Vegetative and Clinical Physiology, Wilhelmstr. 56, 72074 Tübingen, Germany
Matthias Schwab
4University Hospital Tübingen, Department of Clinical Pharmacology, Auf der Morgenstelle 8, D-72076 Tübingen, Germany
9Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany
Alfred Königsrainer
1University Hospital Tübingen, Department of General, Visceral and Transplant Surgery, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany
3German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) partner site Tübingen, D-72076 Tübingen, Germany
Stefan Beckert
1University Hospital Tübingen, Department of General, Visceral and Transplant Surgery, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany
10Department of General and Visceral Surgery, Schwarzwald-Baar Hospital, Klinikstr. 11, 78052 Villingen-Schwenningen, Germany
Posted July 31, 2019.
Short-term oxaliplatin exposure according to established hyperthermic intraperitoneal chemotherapy (HIPEC) protocols lacks effectiveness in vitro and ex vivo
Markus W. Löffler, Nick Seyfried, Markus Burkard, Benedikt Oswald, Alexander Tolios, Can Yurttas, Franziska Herster, Joseph Kauer, Tarkan Jäger, Karolin Thiel, Sebastian P. Haen, Hans-Georg Rammensee, Sascha Venturelli, Matthias Schwab, Alfred Königsrainer, Stefan Beckert
bioRxiv 709055; doi: https://doi.org/10.1101/709055
Short-term oxaliplatin exposure according to established hyperthermic intraperitoneal chemotherapy (HIPEC) protocols lacks effectiveness in vitro and ex vivo
Markus W. Löffler, Nick Seyfried, Markus Burkard, Benedikt Oswald, Alexander Tolios, Can Yurttas, Franziska Herster, Joseph Kauer, Tarkan Jäger, Karolin Thiel, Sebastian P. Haen, Hans-Georg Rammensee, Sascha Venturelli, Matthias Schwab, Alfred Königsrainer, Stefan Beckert
bioRxiv 709055; doi: https://doi.org/10.1101/709055
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