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Movement and performance predict widespread cortical activity in a visual detection task

David B. Salkoff, Edward Zagha, Erin McCarthy, David A. McCormick
doi: https://doi.org/10.1101/709642
David B. Salkoff
1Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
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  • For correspondence: davidmc@uoregon.edu dovsalkoff@gmail.com
Edward Zagha
2Department of Psychology, University of California Riverside, 900 University Ave. Riverside, California 92521, USA
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Erin McCarthy
3Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403
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David A. McCormick
1Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
3Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403
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  • For correspondence: davidmc@uoregon.edu dovsalkoff@gmail.com
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Abstract

Recent studies in mice reveal widespread cortical signals during task performance, however the various task-related and task-independent processes underlying this activity are incompletely understood. Here we recorded wide-field neural activity, as revealed by GCaMP6s, from dorsal cortex while simultaneously monitoring orofacial movements, walking, and arousal (pupil diameter) of head-fixed mice performing a Go/NoGo visual detection task and examined the ability of task performance and spontaneous or task-related movements to predict cortical activity. A linear model was able to explain a significant fraction (33-55% of variance) of widefield dorsal cortical activity, with the largest factors being movements (facial, walk, eye), response choice (hit, miss, false alarm), and arousal, and indicate that a significant fraction of trial-to-trial variability arises from both spontaneous and task-related changes in state (e.g. movements, arousal). Importantly, secondary motor cortex was highly correlated with lick rate, critical for optimal task performance (high d’), and was the first region to significantly predict the lick response on target trials. These findings suggest that secondary motor cortex is critically involved in the decision and performance of learned movements and indicate that a significant fraction of trial-to-trial variation in cortical activity results from spontaneous and task-related movements and variations in behavioral/arousal state.

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Posted July 22, 2019.
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Movement and performance predict widespread cortical activity in a visual detection task
David B. Salkoff, Edward Zagha, Erin McCarthy, David A. McCormick
bioRxiv 709642; doi: https://doi.org/10.1101/709642
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Movement and performance predict widespread cortical activity in a visual detection task
David B. Salkoff, Edward Zagha, Erin McCarthy, David A. McCormick
bioRxiv 709642; doi: https://doi.org/10.1101/709642

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