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A novel subtype of pineal projection neurons expressing melanopsin share a common developmental program with classical projection neurons

Dora Sapède, Clair Chaigne, View ORCID ProfilePatrick Blader, View ORCID ProfileElise Cau
doi: https://doi.org/10.1101/712091
Dora Sapède
1Centre de Biologie du Développement (CBD, UMR5547), Centre de Biologie Intégrative (CBI, FR 3743), Université de Toulouse, CNRS, UPS, France
2IRMB, Université de Montpellier, INSERM, Montpellier, France
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Clair Chaigne
1Centre de Biologie du Développement (CBD, UMR5547), Centre de Biologie Intégrative (CBI, FR 3743), Université de Toulouse, CNRS, UPS, France
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Patrick Blader
1Centre de Biologie du Développement (CBD, UMR5547), Centre de Biologie Intégrative (CBI, FR 3743), Université de Toulouse, CNRS, UPS, France
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Elise Cau
1Centre de Biologie du Développement (CBD, UMR5547), Centre de Biologie Intégrative (CBI, FR 3743), Université de Toulouse, CNRS, UPS, France
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  • For correspondence: elise.cau@univ-tlse3.fr
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Summary

The zebrafish pineal organ is a photoreceptive structure containing two main neuronal populations (photoreceptors and projections neurons). Here we describe a new pineal cell type that harbors both characteristics of projection neurons and photoreceptors. Indeed, a subpopulation of projection neurons expresses the melanopsin gene opn4xa suggesting photoreceptive properties. This population of hybrid cell fates, share a similar behaviour regarding dependency for BMP and Notch signalling pathways with classical non-photosensitive projection neurons (PNs) suggesting they are closer to the PN population. We describe two distinct types of activity within PNs: an achromatic LIGHT OFF activity in opn4xa− PNs and a LIGHT ON activity elicited by green and blue light in opn4xa+ PNs. Altogether the discovery and characterization of opn4xa+ PNs suggest a previously unanticipated heterogeneity in the projection neuron population.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted July 23, 2019.
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A novel subtype of pineal projection neurons expressing melanopsin share a common developmental program with classical projection neurons
Dora Sapède, Clair Chaigne, Patrick Blader, Elise Cau
bioRxiv 712091; doi: https://doi.org/10.1101/712091
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A novel subtype of pineal projection neurons expressing melanopsin share a common developmental program with classical projection neurons
Dora Sapède, Clair Chaigne, Patrick Blader, Elise Cau
bioRxiv 712091; doi: https://doi.org/10.1101/712091

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