New Results
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction
View ORCID ProfileIoanna Ntalla, View ORCID ProfileLu-Chen Weng, James H. Cartwright, View ORCID ProfileAmelia Weber Hall, View ORCID ProfileGardar Sveinbjornsson, View ORCID ProfileNathan R. Tucker, Seung Hoan Choi, Mark D. Chaffin, View ORCID ProfileCarolina Roselli, Michael R. Barnes, View ORCID ProfileBorbala Mifsud, View ORCID ProfileHelen R. Warren, View ORCID ProfileCaroline Hayward, View ORCID ProfileJonathan Marten, View ORCID ProfileJames J. Cranley, View ORCID ProfileMaria Pina Concas, View ORCID ProfilePaolo Gasparini, View ORCID ProfileThibaud Boutin, View ORCID ProfileIvana Kolcic, View ORCID ProfileOzren Polasek, Igor Rudan, Nathalia M. Araujo, Maria Fernanda Lima-Costa, View ORCID ProfileAntonio Luiz P. Ribeiro, Renan P. Souza, Eduardo Tarazona-Santos, View ORCID ProfileVilmantas Giedraitis, View ORCID ProfileErik Ingelsson, View ORCID ProfileAnubha Mahajan, Andrew P. Morris, Greco M. Fabiola Del, View ORCID ProfileLuisa Foco, Martin Gögele, Andrew A. Hicks, James P. Cook, View ORCID ProfileLars Lind, Cecilia M. Lindgren, View ORCID ProfileJohan Sundström, Christopher P. Nelson, Muhammad B. Riaz, View ORCID ProfileNilesh J. Samani, View ORCID ProfileGianfranco Sinagra, View ORCID ProfileSheila Ulivi, Mika Kähönen, View ORCID ProfilePashupati P. Mishra, View ORCID ProfileNina Mononen, View ORCID ProfileKjell Nikus, Mark J. Caulfield, View ORCID ProfileAnna Dominiczak, View ORCID ProfileSandosh Padmanabhan, View ORCID ProfileMay E. Montasser, Jeff R. O’Connell, Kathleen Ryan, View ORCID ProfileAlan R. Shuldiner, View ORCID ProfileStefanie Aeschbacher, David Conen, View ORCID ProfileLorenz Risch, Sébastien Thériault, View ORCID ProfileNina Hutri-Kähönen, Terho Lehtimäki, View ORCID ProfileLeo-Pekka Lyytikäinen, View ORCID ProfileOlli T. Raitakari, View ORCID ProfileCatriona L. K. Barnes, Harry Campbell, View ORCID ProfilePeter K. Joshi, James F. Wilson, Aaron Isaacs, Jan A. Kors, View ORCID ProfileCornelia M. van Duijn, Paul L. Huang, View ORCID ProfileVilmundur Gudnason, View ORCID ProfileTamara B. Harris, View ORCID ProfileLenore J. Launer, Albert V. Smith, View ORCID ProfileErwin P. Bottinger, View ORCID ProfileRuth J. F. Loos, View ORCID ProfileGirish N. Nadkarni, Michael H. Preuss, View ORCID ProfileAdolfo Correa, Hao Mei, James Wilson, View ORCID ProfileThomas Meitinger, View ORCID ProfileMartina Müller-Nurasyid, View ORCID ProfileAnnette Peters, View ORCID ProfileMelanie Waldenberger, Massimo Mangino, Timothy D. Spector, View ORCID ProfileMichiel Rienstra, View ORCID ProfileYordi J. van de Vegte, View ORCID ProfilePim van der Harst, View ORCID ProfileNiek Verweij, Stefan Kääb, Katharina Schramm, Moritz F. Sinner, Konstantin Strauch, Michael J. Cutler, View ORCID ProfileDiane Fatkin, View ORCID ProfileBarry London, Morten Olesen, View ORCID ProfileDan M. Roden, View ORCID ProfileM. Benjamin Shoemaker, View ORCID ProfileJ. Gustav Smith, Mary L. Biggs, View ORCID ProfileJoshua C. Bis, View ORCID ProfileJennifer A. Brody, View ORCID ProfileBruce M. Psaty, Ken Rice, Nona Sotoodehnia, View ORCID ProfileAlessandro De Grandi, View ORCID ProfileChristian Fuchsberger, Cristian Pattaro, View ORCID ProfilePeter P. Pramstaller, Ian Ford, View ORCID ProfileJ. Wouter Jukema, Peter W. Macfarlane, View ORCID ProfileStella Trompet, Marcus Dörr, View ORCID ProfileStephan B. Felix, Uwe Völker, Stefan Weiss, View ORCID ProfileAki S. Havulinna, View ORCID ProfileAntti Jula, Katri Sääksjärvi, View ORCID ProfileVeikko Salomaa, View ORCID ProfileXiuqing Guo, View ORCID ProfileSusan R. Heckbert, Henry J. Lin, View ORCID ProfileJerome I. Rotter, View ORCID ProfileKent D. Taylor, Jie Yao, Renée de Mutsert, View ORCID ProfileArie C. Maan, Dennis O. Mook-Kanamori, Raymond Noordam, View ORCID ProfileFrancesco Cucca, Jun Ding, View ORCID ProfileEdward G. Lakatta, Yong Qian, View ORCID ProfileKirill V. Tarasov, Daniel Levy, Honghuang Lin, View ORCID ProfileChristopher H. Newton-Cheh, Kathryn L. Lunetta, Alison D. Murray, View ORCID ProfileDavid J. Porteous, Blair H. Smith, View ORCID ProfileBruno H. Stricker, André Uitterlinden, View ORCID ProfileMarten E. van den Berg, Jeffrey Haessler, Rebecca D. Jackson, Charles Kooperberg, Ulrike Peters, Alexander P. Reiner, View ORCID ProfileEric A. Whitsel, View ORCID ProfileAlvaro Alonso, View ORCID ProfileDan E. Arking, View ORCID ProfileEric Boerwinkle, Georg B. Ehret, View ORCID ProfileElsayed Z. Soliman, View ORCID ProfileChristy L. Avery, View ORCID ProfileStephanie M. Gogarten, Kathleen F. Kerr, Cathy C. Laurie, View ORCID ProfileAmanda A. Seyerle, Adrienne Stilp, View ORCID ProfileSolmaz Assa, M. Abdullah Said, View ORCID ProfileM. Yldau van der Ende, View ORCID ProfilePier D. Lambiase, Michele Orini, Julia Ramirez, View ORCID ProfileStefan Van Duijvenboden, View ORCID ProfileDavid O. Arnar, View ORCID ProfileDaniel F. Gudbjartsson, View ORCID ProfileHilma Holm, View ORCID ProfilePatrick Sulem, View ORCID ProfileGudmar Thorleifsson, View ORCID ProfileRosa B. Thorolfsdottir, View ORCID ProfileUnnur Thorsteinsdottir, View ORCID ProfileEmelia J. Benjamin, View ORCID ProfileAndrew Tinker, View ORCID ProfileKari Stefansson, View ORCID ProfilePatrick T. Ellinor, View ORCID ProfileYalda Jamshidi, View ORCID ProfileSteven A. Lubitz, View ORCID ProfilePatricia B. Munroe
doi: https://doi.org/10.1101/712398
Ioanna Ntalla
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Lu-Chen Weng
2Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
James H. Cartwright
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Amelia Weber Hall
2Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
Gardar Sveinbjornsson
4deCODE genetics/Amgen, Inc., Reykjavik, Iceland
Nathan R. Tucker
2Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
Seung Hoan Choi
3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
Mark D. Chaffin
3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
Carolina Roselli
3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
5University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands
Michael R. Barnes
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
6National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK
Borbala Mifsud
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
7College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, Qatar
Helen R. Warren
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
6National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK
Caroline Hayward
8Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
Jonathan Marten
8Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
James J. Cranley
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Maria Pina Concas
9Institute for Maternal and Child Health-IRCCS ‘Burlo Garofolo’, Trieste, Italy
Paolo Gasparini
9Institute for Maternal and Child Health-IRCCS ‘Burlo Garofolo’, Trieste, Italy
10University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy
Thibaud Boutin
8Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
Ivana Kolcic
11University of Split School of Medicine, Split, Croatia
Ozren Polasek
11University of Split School of Medicine, Split, Croatia
12Clinical Hospital Centre Split, Split, Croatia
13Psychiatric Hospital Sveti Ivan, Zagreb, Croatia
Igor Rudan
14Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
Nathalia M. Araujo
15Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Maria Fernanda Lima-Costa
16Rene Rachou Reserch Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil
Antonio Luiz P. Ribeiro
17Hospital das Clínicas e Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Renan P. Souza
15Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Eduardo Tarazona-Santos
15Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Vilmantas Giedraitis
18Department of Public Health, Geriatrics, Uppsala University, Uppsala, Sweden
Erik Ingelsson
19Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
20Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA
21Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA
22Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Anubha Mahajan
23Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
Andrew P. Morris
23Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
24Department of Biostatistics, University of Liverpool, Liverpool, UK
25Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK
Greco M. Fabiola Del
26Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy
Luisa Foco
26Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy
Martin Gögele
26Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy
Andrew A. Hicks
26Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy
James P. Cook
24Department of Biostatistics, University of Liverpool, Liverpool, UK
Lars Lind
27Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
Cecilia M. Lindgren
28Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
29The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
30The Broad Institute of MIT and Harvard, Cambridge, MA, USA
Johan Sundström
31Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Christopher P. Nelson
32Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK
33NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK
Muhammad B. Riaz
32Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK
33NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK
Nilesh J. Samani
32Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK
33NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK
Gianfranco Sinagra
34Cardiovascular Department, Azienda Ospedaliera Universitaria Integrata of Trieste, Trieste, Italy
Sheila Ulivi
9Institute for Maternal and Child Health-IRCCS ‘Burlo Garofolo’, Trieste, Italy
Mika Kähönen
35Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
36Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Pashupati P. Mishra
37Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland
38Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Nina Mononen
37Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland
38Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Kjell Nikus
39Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland
40Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Mark J. Caulfield
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
6National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK
Anna Dominiczak
41Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Sandosh Padmanabhan
41Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
42Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
May E. Montasser
43Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA
44Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Jeff R. O’Connell
43Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA
44Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Kathleen Ryan
43Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA
44Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Alan R. Shuldiner
43Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA
44Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Stefanie Aeschbacher
45Cardiology Division, University Hospital, Basel, Switzerland
David Conen
45Cardiology Division, University Hospital, Basel, Switzerland
46Population Health Research Institute, McMaster University, Hamilton, Canada
Lorenz Risch
47Institute of Clinical Chemistry, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland
48Labormedizinisches Zentrum Dr. Risch, Vaduz, Liechtenstein
49Private University of the Principality of Liechtenstein, Triesen, Liechtenstein
Sébastien Thériault
46Population Health Research Institute, McMaster University, Hamilton, Canada
50Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, Canada
Nina Hutri-Kähönen
51Department of Pediatrics, Tampere University Hospital, Tampere, Finland
52Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Terho Lehtimäki
37Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland
38Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Leo-Pekka Lyytikäinen
37Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland
38Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
39Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland
Olli T. Raitakari
53Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
54Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
55Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland
Catriona L. K. Barnes
14Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
Harry Campbell
14Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
Peter K. Joshi
14Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
James F. Wilson
8Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
14Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
Aaron Isaacs
56CARIM School for Cardiovascular Diseases, Maastricht Center for Systems Biology (MaCSBio), Department. of Biochemistry, and Dept. of Physiology, Maastricht University, Maastricht, Netherlands
Jan A. Kors
57Department of Medical Informatics Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
Cornelia M. van Duijn
58Genetic Epidemiology Unit, Dept. of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands
Paul L. Huang
2Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
Vilmundur Gudnason
59Icelandic Heart Association, Kopavogur, Iceland
60Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Tamara B. Harris
61Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA
Lenore J. Launer
61Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA
Albert V. Smith
59Icelandic Heart Association, Kopavogur, Iceland
62School of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA
Erwin P. Bottinger
63The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Ruth J. F. Loos
63The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
64The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, New York, NY, USA
Girish N. Nadkarni
63The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Michael H. Preuss
63The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Adolfo Correa
65Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
Hao Mei
66Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA
James Wilson
67Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
Thomas Meitinger
68DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
69Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
70Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
Martina Müller-Nurasyid
68DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
71Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
72Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany
73Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany
Annette Peters
68DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
74German Center for Diabetes Research, Neuherberg, Germany
75Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
Melanie Waldenberger
68DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
75Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
76Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
Massimo Mangino
77Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK
78NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, UK
Timothy D. Spector
77Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK
Michiel Rienstra
5University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands
Yordi J. van de Vegte
5University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands
Pim van der Harst
5University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands
Niek Verweij
5University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands
79Genomics plc, Oxford, UK
Stefan Kääb
68DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
73Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany
Katharina Schramm
68DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
71Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
73Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany
Moritz F. Sinner
68DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
73Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany
Konstantin Strauch
71Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
72Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany
Michael J. Cutler
80Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA
Diane Fatkin
81Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, Australia
82Cardiology Department, St. Vincent’s Hospital, Darlinghurst, Australia
83St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Kensington, Australia
Barry London
84Department of Cardiovascular Medicine, University of Iowa, Iowa City, Iowa, USA
Morten Olesen
85Laboratory for Molecular Cardiology, Department of Cardiology, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
86Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Dan M. Roden
87Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
M. Benjamin Shoemaker
88Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
J. Gustav Smith
89Department of Cardiology, Clinical Sciences; Wallenberg Center for Molecular Medicine; Lund University Diabetes Center; Lund University and Skane University Hospital, Lund, Sweden, Lund, Sweden
Mary L. Biggs
90Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
91Department of Biostatistics, University of Washington, Seattle, WA, USA
Joshua C. Bis
90Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
Jennifer A. Brody
90Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
Bruce M. Psaty
90Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
92Department of Epidemiology, University of Washington, Seattle, WA, USA
93Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
Ken Rice
91Department of Biostatistics, University of Washington, Seattle, WA, USA
Nona Sotoodehnia
90Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
92Department of Epidemiology, University of Washington, Seattle, WA, USA
94Cardiology Division, University of Washington, Seattle, WA, USA
Alessandro De Grandi
26Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy
Christian Fuchsberger
26Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy
Cristian Pattaro
26Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy
Peter P. Pramstaller
26Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy
Ian Ford
95Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK
J. Wouter Jukema
96Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
97Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Peter W. Macfarlane
98Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Stella Trompet
99Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
Marcus Dörr
100DZHK (German Centre for Cardiovascular Research); partner site Greifswald, Greifswald, Germany
101Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine; University Medicine Greifswald, Greifswald, Germany
Stephan B. Felix
100DZHK (German Centre for Cardiovascular Research); partner site Greifswald, Greifswald, Germany
101Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine; University Medicine Greifswald, Greifswald, Germany
Uwe Völker
100DZHK (German Centre for Cardiovascular Research); partner site Greifswald, Greifswald, Germany
102Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genonics; University Medicine and University of Greifswald, Greifswald, Germany
Stefan Weiss
100DZHK (German Centre for Cardiovascular Research); partner site Greifswald, Greifswald, Germany
102Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genonics; University Medicine and University of Greifswald, Greifswald, Germany
Aki S. Havulinna
103National Institute for Health and Welfare, Helsinki, Finland
104Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
Antti Jula
103National Institute for Health and Welfare, Helsinki, Finland
Katri Sääksjärvi
103National Institute for Health and Welfare, Helsinki, Finland
Veikko Salomaa
103National Institute for Health and Welfare, Helsinki, Finland
Xiuqing Guo
105Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Susan R. Heckbert
106Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA
Henry J. Lin
105Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Jerome I. Rotter
107Institute for Translational Genomics and Population Sciences and Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Kent D. Taylor
105Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Jie Yao
108Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Renée de Mutsert
109Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
Arie C. Maan
96Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
Dennis O. Mook-Kanamori
109Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
110Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands
Raymond Noordam
99Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
Francesco Cucca
111Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Jun Ding
112Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA
Edward G. Lakatta
113Laboratory Of Cardiovascular Science, NIA/NIH, Baltimore, MD, USA
Yong Qian
112Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA
Kirill V. Tarasov
113Laboratory Of Cardiovascular Science, NIA/NIH, Baltimore, MD, USA
Daniel Levy
114Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
115National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, USA
Honghuang Lin
115National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, USA
116Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Christopher H. Newton-Cheh
3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
117Center for Human Genetic Research and Cardiovascular Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
Kathryn L. Lunetta
115National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, USA
118Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Alison D. Murray
119The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK
David J. Porteous
120Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
121Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
Blair H. Smith
122Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
Bruno H. Stricker
123Department of Epidemiology Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
André Uitterlinden
124Human Genotyping Facility Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
Marten E. van den Berg
123Department of Epidemiology Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
Jeffrey Haessler
125Fred Hutchinson Cancer Research Center, Division of Pubic Health Sciences, Seattle, WA, USA
Rebecca D. Jackson
126Ohio State University, Division of Endocrinology, Diabetes and Metabolism, Columbus, OH, USA
Charles Kooperberg
125Fred Hutchinson Cancer Research Center, Division of Pubic Health Sciences, Seattle, WA, USA
Ulrike Peters
125Fred Hutchinson Cancer Research Center, Division of Pubic Health Sciences, Seattle, WA, USA
Alexander P. Reiner
125Fred Hutchinson Cancer Research Center, Division of Pubic Health Sciences, Seattle, WA, USA
127University of Washington, Department of Epidemiology, Seattle, WA, USA
Eric A. Whitsel
128University of North Carolina, Gillings School of Global Public Health and School of Medicine, Departments of Epidemiology and Medicine, Chapel Hill, NC, USA
Alvaro Alonso
129Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
Dan E. Arking
130McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Eric Boerwinkle
131Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
Georg B. Ehret
132Cardiology, Geneva University Hospitals, Geneva, Switzerland
Elsayed Z. Soliman
133Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA
Christy L. Avery
134Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
135Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA
Stephanie M. Gogarten
91Department of Biostatistics, University of Washington, Seattle, WA, USA
Kathleen F. Kerr
91Department of Biostatistics, University of Washington, Seattle, WA, USA
Cathy C. Laurie
91Department of Biostatistics, University of Washington, Seattle, WA, USA
Amanda A. Seyerle
136Division of Pharmaceutical Outcomes and Policy, University of North Carolina, Chapel Hill, NC, USA
Adrienne Stilp
91Department of Biostatistics, University of Washington, Seattle, WA, USA
Solmaz Assa
5University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands
M. Abdullah Said
5University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands
M. Yldau van der Ende
5University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands
Pier D. Lambiase
137Barts Heart Centre, St Bartholomews Hospital, London, United Kingdom, London, UK
138Institute of Cardiovascular Science, University College London, London, UK
Michele Orini
137Barts Heart Centre, St Bartholomews Hospital, London, United Kingdom, London, UK
139Department of Mechanical Engineering, University College London, London, UK
Julia Ramirez
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
138Institute of Cardiovascular Science, University College London, London, UK
Stefan Van Duijvenboden
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
138Institute of Cardiovascular Science, University College London, London, UK
David O. Arnar
4deCODE genetics/Amgen, Inc., Reykjavik, Iceland
60Faculty of Medicine, University of Iceland, Reykjavik, Iceland
140Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland
Daniel F. Gudbjartsson
4deCODE genetics/Amgen, Inc., Reykjavik, Iceland
141School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
Hilma Holm
4deCODE genetics/Amgen, Inc., Reykjavik, Iceland
Patrick Sulem
4deCODE genetics/Amgen, Inc., Reykjavik, Iceland
Gudmar Thorleifsson
4deCODE genetics/Amgen, Inc., Reykjavik, Iceland
Rosa B. Thorolfsdottir
4deCODE genetics/Amgen, Inc., Reykjavik, Iceland
60Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Unnur Thorsteinsdottir
4deCODE genetics/Amgen, Inc., Reykjavik, Iceland
60Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Emelia J. Benjamin
115National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, USA
142Section of Cardiovascular Medicine and Section of Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
143Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
Andrew Tinker
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
6National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK
Kari Stefansson
4deCODE genetics/Amgen, Inc., Reykjavik, Iceland
60Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Patrick T. Ellinor
2Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
144Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA
Yalda Jamshidi
145Genetics Research Centre, Molecular and Clinical Sciences Institute, St George’s, University of London, London, UK
Steven A. Lubitz
2Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
144Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA
Patricia B. Munroe
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
6National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK
Abstract
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality1,2. We performed multi-ancestry (N=293,051) and European only (N=271,570) genome-wide association (GWAS) meta-analyses for the PR interval, discovering 210 loci of which 149 are novel. Variants at all loci nearly doubled the percentage of heritability explained, from 33.5% to 62.6%. We observed enrichment for genes involved in cardiac muscle development/contraction and the cytoskeleton highlighting key regulation processes for atrioventricular conduction. Additionally, 19 novel loci harbour genes underlying inherited monogenic heart diseases suggesting the role of these genes in cardiovascular pathology in the general population. We showed that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease risk, including distal conduction disease, AF, atrioventricular pre-excitation, non-ischemic cardiomyopathy, and coronary heart disease. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease.
Footnotes
To correct the names of two co-authors in the HTML.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted July 30, 2019.
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction
Ioanna Ntalla, Lu-Chen Weng, James H. Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R. Tucker, Seung Hoan Choi, Mark D. Chaffin, Carolina Roselli, Michael R. Barnes, Borbala Mifsud, Helen R. Warren, Caroline Hayward, Jonathan Marten, James J. Cranley, Maria Pina Concas, Paolo Gasparini, Thibaud Boutin, Ivana Kolcic, Ozren Polasek, Igor Rudan, Nathalia M. Araujo, Maria Fernanda Lima-Costa, Antonio Luiz P. Ribeiro, Renan P. Souza, Eduardo Tarazona-Santos, Vilmantas Giedraitis, Erik Ingelsson, Anubha Mahajan, Andrew P. Morris, Greco M. Fabiola Del, Luisa Foco, Martin Gögele, Andrew A. Hicks, James P. Cook, Lars Lind, Cecilia M. Lindgren, Johan Sundström, Christopher P. Nelson, Muhammad B. Riaz, Nilesh J. Samani, Gianfranco Sinagra, Sheila Ulivi, Mika Kähönen, Pashupati P. Mishra, Nina Mononen, Kjell Nikus, Mark J. Caulfield, Anna Dominiczak, Sandosh Padmanabhan, May E. Montasser, Jeff R. O’Connell, Kathleen Ryan, Alan R. Shuldiner, Stefanie Aeschbacher, David Conen, Lorenz Risch, Sébastien Thériault, Nina Hutri-Kähönen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Olli T. Raitakari, Catriona L. K. Barnes, Harry Campbell, Peter K. Joshi, James F. Wilson, Aaron Isaacs, Jan A. Kors, Cornelia M. van Duijn, Paul L. Huang, Vilmundur Gudnason, Tamara B. Harris, Lenore J. Launer, Albert V. Smith, Erwin P. Bottinger, Ruth J. F. Loos, Girish N. Nadkarni, Michael H. Preuss, Adolfo Correa, Hao Mei, James Wilson, Thomas Meitinger, Martina Müller-Nurasyid, Annette Peters, Melanie Waldenberger, Massimo Mangino, Timothy D. Spector, Michiel Rienstra, Yordi J. van de Vegte, Pim van der Harst, Niek Verweij, Stefan Kääb, Katharina Schramm, Moritz F. Sinner, Konstantin Strauch, Michael J. Cutler, Diane Fatkin, Barry London, Morten Olesen, Dan M. Roden, M. Benjamin Shoemaker, J. Gustav Smith, Mary L. Biggs, Joshua C. Bis, Jennifer A. Brody, Bruce M. Psaty, Ken Rice, Nona Sotoodehnia, Alessandro De Grandi, Christian Fuchsberger, Cristian Pattaro, Peter P. Pramstaller, Ian Ford, J. Wouter Jukema, Peter W. Macfarlane, Stella Trompet, Marcus Dörr, Stephan B. Felix, Uwe Völker, Stefan Weiss, Aki S. Havulinna, Antti Jula, Katri Sääksjärvi, Veikko Salomaa, Xiuqing Guo, Susan R. Heckbert, Henry J. Lin, Jerome I. Rotter, Kent D. Taylor, Jie Yao, Renée de Mutsert, Arie C. Maan, Dennis O. Mook-Kanamori, Raymond Noordam, Francesco Cucca, Jun Ding, Edward G. Lakatta, Yong Qian, Kirill V. Tarasov, Daniel Levy, Honghuang Lin, Christopher H. Newton-Cheh, Kathryn L. Lunetta, Alison D. Murray, David J. Porteous, Blair H. Smith, Bruno H. Stricker, André Uitterlinden, Marten E. van den Berg, Jeffrey Haessler, Rebecca D. Jackson, Charles Kooperberg, Ulrike Peters, Alexander P. Reiner, Eric A. Whitsel, Alvaro Alonso, Dan E. Arking, Eric Boerwinkle, Georg B. Ehret, Elsayed Z. Soliman, Christy L. Avery, Stephanie M. Gogarten, Kathleen F. Kerr, Cathy C. Laurie, Amanda A. Seyerle, Adrienne Stilp, Solmaz Assa, M. Abdullah Said, M. Yldau van der Ende, Pier D. Lambiase, Michele Orini, Julia Ramirez, Stefan Van Duijvenboden, David O. Arnar, Daniel F. Gudbjartsson, Hilma Holm, Patrick Sulem, Gudmar Thorleifsson, Rosa B. Thorolfsdottir, Unnur Thorsteinsdottir, Emelia J. Benjamin, Andrew Tinker, Kari Stefansson, Patrick T. Ellinor, Yalda Jamshidi, Steven A. Lubitz, Patricia B. Munroe
bioRxiv 712398; doi: https://doi.org/10.1101/712398
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction
Ioanna Ntalla, Lu-Chen Weng, James H. Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R. Tucker, Seung Hoan Choi, Mark D. Chaffin, Carolina Roselli, Michael R. Barnes, Borbala Mifsud, Helen R. Warren, Caroline Hayward, Jonathan Marten, James J. Cranley, Maria Pina Concas, Paolo Gasparini, Thibaud Boutin, Ivana Kolcic, Ozren Polasek, Igor Rudan, Nathalia M. Araujo, Maria Fernanda Lima-Costa, Antonio Luiz P. Ribeiro, Renan P. Souza, Eduardo Tarazona-Santos, Vilmantas Giedraitis, Erik Ingelsson, Anubha Mahajan, Andrew P. Morris, Greco M. Fabiola Del, Luisa Foco, Martin Gögele, Andrew A. Hicks, James P. Cook, Lars Lind, Cecilia M. Lindgren, Johan Sundström, Christopher P. Nelson, Muhammad B. Riaz, Nilesh J. Samani, Gianfranco Sinagra, Sheila Ulivi, Mika Kähönen, Pashupati P. Mishra, Nina Mononen, Kjell Nikus, Mark J. Caulfield, Anna Dominiczak, Sandosh Padmanabhan, May E. Montasser, Jeff R. O’Connell, Kathleen Ryan, Alan R. Shuldiner, Stefanie Aeschbacher, David Conen, Lorenz Risch, Sébastien Thériault, Nina Hutri-Kähönen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Olli T. Raitakari, Catriona L. K. Barnes, Harry Campbell, Peter K. Joshi, James F. Wilson, Aaron Isaacs, Jan A. Kors, Cornelia M. van Duijn, Paul L. Huang, Vilmundur Gudnason, Tamara B. Harris, Lenore J. Launer, Albert V. Smith, Erwin P. Bottinger, Ruth J. F. Loos, Girish N. Nadkarni, Michael H. Preuss, Adolfo Correa, Hao Mei, James Wilson, Thomas Meitinger, Martina Müller-Nurasyid, Annette Peters, Melanie Waldenberger, Massimo Mangino, Timothy D. Spector, Michiel Rienstra, Yordi J. van de Vegte, Pim van der Harst, Niek Verweij, Stefan Kääb, Katharina Schramm, Moritz F. Sinner, Konstantin Strauch, Michael J. Cutler, Diane Fatkin, Barry London, Morten Olesen, Dan M. Roden, M. Benjamin Shoemaker, J. Gustav Smith, Mary L. Biggs, Joshua C. Bis, Jennifer A. Brody, Bruce M. Psaty, Ken Rice, Nona Sotoodehnia, Alessandro De Grandi, Christian Fuchsberger, Cristian Pattaro, Peter P. Pramstaller, Ian Ford, J. Wouter Jukema, Peter W. Macfarlane, Stella Trompet, Marcus Dörr, Stephan B. Felix, Uwe Völker, Stefan Weiss, Aki S. Havulinna, Antti Jula, Katri Sääksjärvi, Veikko Salomaa, Xiuqing Guo, Susan R. Heckbert, Henry J. Lin, Jerome I. Rotter, Kent D. Taylor, Jie Yao, Renée de Mutsert, Arie C. Maan, Dennis O. Mook-Kanamori, Raymond Noordam, Francesco Cucca, Jun Ding, Edward G. Lakatta, Yong Qian, Kirill V. Tarasov, Daniel Levy, Honghuang Lin, Christopher H. Newton-Cheh, Kathryn L. Lunetta, Alison D. Murray, David J. Porteous, Blair H. Smith, Bruno H. Stricker, André Uitterlinden, Marten E. van den Berg, Jeffrey Haessler, Rebecca D. Jackson, Charles Kooperberg, Ulrike Peters, Alexander P. Reiner, Eric A. Whitsel, Alvaro Alonso, Dan E. Arking, Eric Boerwinkle, Georg B. Ehret, Elsayed Z. Soliman, Christy L. Avery, Stephanie M. Gogarten, Kathleen F. Kerr, Cathy C. Laurie, Amanda A. Seyerle, Adrienne Stilp, Solmaz Assa, M. Abdullah Said, M. Yldau van der Ende, Pier D. Lambiase, Michele Orini, Julia Ramirez, Stefan Van Duijvenboden, David O. Arnar, Daniel F. Gudbjartsson, Hilma Holm, Patrick Sulem, Gudmar Thorleifsson, Rosa B. Thorolfsdottir, Unnur Thorsteinsdottir, Emelia J. Benjamin, Andrew Tinker, Kari Stefansson, Patrick T. Ellinor, Yalda Jamshidi, Steven A. Lubitz, Patricia B. Munroe
bioRxiv 712398; doi: https://doi.org/10.1101/712398
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