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Sleep spindles mediate hippocampal-neocortical coupling during sharp-wave ripples

View ORCID ProfileHong-Viet. V. Ngo, Juergen Fell, Bernhard P. Staresina
doi: https://doi.org/10.1101/712463
Hong-Viet. V. Ngo
1School of Psychology & Centre for Human Brain Health, University of Birmingham, Birmingham, B15 2TT, United Kingdom
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  • ORCID record for Hong-Viet. V. Ngo
Juergen Fell
2Department of Epileptology, University of Bonn, Bonn, 53127, Germany
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Bernhard P. Staresina
1School of Psychology & Centre for Human Brain Health, University of Birmingham, Birmingham, B15 2TT, United Kingdom
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  • For correspondence: b.staresina@bham.ac.uk
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Abstract

Sleep is pivotal for the consolidation of memories [1]. According to two-stage accounts, experiences are temporarily stored in the hippocampus and gradually translocated to neocortical sites during non-rapid-eye-movement (NREM) sleep [2,3]. Mechanistically, information transfer is thought to rely on interactions between thalamocortical spindles and hippocampal ripples. In particular, spindles may open precisely-timed communication channels, across which reactivation patterns may travel between the hippocampus and cortical target sites when ripples occur. To test this hypothesis, we first derived time-frequency representations (TFRs) in hippocampus (HIPP) and at scalp electrode Cz (neocortex, NC) time-locked to individual hippocampal ripple events. Compared to matched ripple-free intervals, results revealed a concurrent increase in spindle power both in HIPP and NC. As revealed by coherence analysis, hippocampal-neocortical coupling was indeed enhanced in the spindle band around ripples. Finally, we examined the directionality of spindle coupling and observed a strong driving effect from NC to HIPP. Specifically, ∼250 ms prior to the HIPP ripple, NC spindles emerge and entrain HIPP spindles. Both regions then remain synchronised until ∼500 ms after the ripple. Consistent with recent rodent work, these findings suggest that active consolidation is initiated by neocortex and draws on neocortical-hippocampal-neocortical reactivation loops [4], with a role of sleep spindles in mediating this process.

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Posted July 23, 2019.
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Sleep spindles mediate hippocampal-neocortical coupling during sharp-wave ripples
Hong-Viet. V. Ngo, Juergen Fell, Bernhard P. Staresina
bioRxiv 712463; doi: https://doi.org/10.1101/712463
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Sleep spindles mediate hippocampal-neocortical coupling during sharp-wave ripples
Hong-Viet. V. Ngo, Juergen Fell, Bernhard P. Staresina
bioRxiv 712463; doi: https://doi.org/10.1101/712463

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