Article Information
- July 24, 2019.
Author Information
- Stephan B. Dreyer1,2,
- Rosie Upstill-Goddard1,
- Viola Paulus-Hock3,
- Clara Paris4,
- Eirini-Maria Lampraki1,
- Eloise Dray5,
- Bryan Serrels1,6,
- Giuseppina Caligiuri1,
- Selma Rebus1,
- Holly Brunton1,
- Richard Cunningham1,
- Craig Nourse3,
- Ulla-Maja Bailey1,
- Marc Jones7,
- Kim Moran-Jones8,
- Derek W. Wright1,
- Fraser Duthie1,9,
- Karin Oien1,9,10,
- Lisa Evers11,
- Colin J. McKay1,2,
- Grant A. McGregor3,
- Aditi Gulati11,
- Rachel Brough11,
- Ilirjana Bajrami11,
- Stephan Pettitt11,
- Michele L. Dziubinski12,
- Juliana Candido13,
- Frances Balkwill13,
- Simon T. Barry14,
- Robert Grützmann15,
- Lola Rahib16,
- Glasgow Precision Oncology Laboratory17,
- Australian Pancreatic Cancer Genome Initiative18,
- Amber Johns19,
- Marina Pajic19,
- Fieke E. M. Froeling20,21,
- Phillip Beer22,
- Elizabeth A. Musgrove1,
- Gloria M. Petersen23,
- Alan Ashworth11,24,
- Margaret C. Frame6,
- Howard C. Crawford12,
- Diane M. Simeone25,
- Chris Lord11,
- Debabrata Mukhopadhyay26,
- Christian Pilarsky15,
- Susanna L. Cooke1,
- Nigel B. Jamieson1,2,
- Jennifer P. Morton1,3,
- Owen J. Sansom1,5,
- Peter J. Bailey3,
- Andrew V. Biankin1,2,27,§ and
- David K. Chang*,1,2,27,§
- 1Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow, Scotland G61 1QH, UNITED KINGDOM
- 2West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow G31 2ER UNITED KINGDOM
- 3Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UNITED KINGDOM
- 4Clara Paris
- 5UT Health San Antonio Department of Biochemistry and Structural Biology San Antonio, TX 78229-3900 U.S.A.
- 6MRC Institute of Genetics & Molecular Medicine, Edinburgh Cancer Research UK Centre, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UNITED KINGDOM
- 7Stratified Medicine Scotland, Queen Elizabeth University Hospital, Glasgow, G51 4TF, UNITED KINGDOM
- 8College of Medicine, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8TA, UNITED KINGDOM
- 9Department of Pathology, Queen Elizabeth University Hospital, Glasgow, G51 4TF, UNITED KINGDOM
- 10Greater Glasgow and Clyde Bio-repository, Pathology Department, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow, G51 4TY, UNITED KINGDOM
- 11CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UNITED KINGDOM
- 12Department of Molecular and Integrative Physiology, University of Michigan, 1137 E. Catherine St., An Arbor, MI, 48109, USA
- 13Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1 M6BQ, UNITED KINGDOM
- 14Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UNITED KINGDOM
- 15Department of Surgery, Universitätsklinikum Erlangen, Erlangen, GERMANY
- 16Pancreatic Cancer Action Network, Manhattan Beach, California, USA
- 17The list of Glasgow Precision Oncology Laboratory and their affiliations is at the end of the paper
- 18The list of Australian Pancreas Genome Initiative and their affiliations is at the end of the paper
- 19The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst and Garvan Institute of Medical Research, Sydney, NSW 2010, AUSTRALIA
- 20Epigenetics Unit, Department of Surgery & Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UNITED KINGDOM
- 21Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA, 11724
- 22Sanger Institute, Wellcome Genome Campus, Cambridge, UNITED KINGDOM
- 23Mayo Clinic, Rochester, Minnesota, 55905, USA
- 24UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, 94158, USA
- 25Pancreatic Cancer Center, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, USA
- 26Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL 32224, USA
- 27South Western Sydney Clinical School, Faculty of Medicine, University of NSW, Liverpool NSW 2170, Australia
- ↵*Corresponding authors: David K. Chang, Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow Scotland G61 1BD, Tel: +44 141 330 7589 Fax: +44 141 330 5834, Email: david.chang{at}glasgow.ac.uk, Andrew V. Biankin, Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow Scotland G61 1BD, Tel: +44 141 330 5670 Fax: +44 141 330 5834, Email: andrew.biankin{at}glasgow.ac.uk
- 1Glasgow Precision Oncology Laboratory, University of Glasgow, Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Garscube Estate, Switchback Road, Glasgow, G61 1QH, United Kingdom
- 2West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, G31 2ER, United Kingdom
- 3Department of Pathology, Southern General Hospital, Greater Glasgow & Clyde NHS, Glasgow, G51 4TF, United Kingdom
- 4West of Scotland Genetic Services, NHS Greater Glasgow and Clyde, Queen Elizabeth University Hospital Campus, Glasgow, G51 4TF, United Kingdom
- 1The Kinghorn Cancer Centre, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
- 2Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia
- 3Royal North Shore Hospital, Westbourne Street, St Leonards, New South Wales 2065, Australia
- 4Bankstown Hospital, Eldridge Road, Bankstown, New South Wales 2200, Australia
- 5Liverpool Hospital, Elizabeth Street, Liverpool, New South Wales 2170, Australia
- 6Westmead Hospital, Hawkesbury and Darcy Roads, Westmead, New South Wales 2145, Australia
- 7Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales 2050, Australia
- 8Fremantle Hospital, Alma Street, Fremantle, Western Australia 6959, Australia
- 9Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia 6009, Australia
- 10St John of God Healthcare, 12 Salvado Road, Subiaco, Western Australia 6008, Australia
- 11Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
- 12Flinders Medical Centre, Flinders Drive, Bedford Park, South Australia 5042, Australia
- 13Greenslopes Private Hospital, Newdegate Street, Greenslopes, Queensland 4120, Australia
- 14Envoi Pathology, 1/49 Butterfield Street, Herston, Queensland 4006, Australia
- 15Princess Alexandria Hospital, Cornwall Street & Ipswich Road, Woolloongabba, Queensland 4102, Australia
- 16Austin Hospital, 145 Studley Road, Heidelberg, Victoria 3084, Australia
- 17Victorian Cancer Biobank, 1 Rathdown Street, Carlton, Victoria 3053, Australia
- 18Johns Hopkins Medical Institute, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
- 19ARC-NET Center for Applied Research on Cancer, University of Verona, Via dell’Artigliere, 19 37129 Verona, Province of Verona, Italy
- 20University of California, San Francisco, 500 Parnassus Avenue, San Francisco, California 94122, USA
- 21Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow, Scotland G61 1BD, United Kingdom
- 22Greater Glasgow and Clyde National Health Service, 1053 Great Western Road, Glasgow G12 0YN, United Kingdom
↵§ These authors equally supervised this work.
Author Contributions: Attracted funding for the study: S.B.D., A.V.B., D.M.S., G.M.P. R.G.. Study conception: S.B.D., P.J.B., O.J.S., D.K.C., A.V.B. Study Design: S.B.D., P.J.B., D.K.C. A.V.B. PDCL generation: M.P., D.K.C., C.P., D.M.S., M.L.D, H.C., D.M.. Facilitated provision of clinical samples, histopathology and information: A.P.G.I.., N.B.J., C.J.M., D.B.G., J.S.G., F.D., K.O., G.M.P., D.M., E.A.M., A.V.B., D.K.C.. Functional Screens: A.G., R.B., I.B., C.L., A.A.. Therapeutic testing: S.D., H.B., G.C., R.C., E.M.L., LK.M.J. I.M.G., F.E.M.F.. RPPA: B.S.. Functional analysis: H.B., G.C., R.C., S.D., M.F., B.S., K.M.J.. Processed tissue samples and extracted, quantified DNA and RNA: M.J., L.E.. Performed library preparation and sequencing: L.E., C.N., GPOL. Sequence data management and variant identification: S.C., P.B, P.J.B., GPOL. Data analysis: S.B.D., P.J.B., R.U-G., Wrote manuscript: S.B.D., D.K.C., A.V.B. All authors read and approved the final manuscript.