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Metabolic Profiling of Aortic Stenosis and Hypertrophic Cardiomyopathy Identifies Mechanistic Contrasts in Substrate Utilisation
Nikhil Pal, Animesh Acharjee, Zsuzsanna Ament, Tim Dent, Arash Yavari, Masliza Mahmod, Rina Ariga, James West, Violetta Steeples, Mark Cassar, Neil J. Howell, Helen Lockstone, Kate Elliott, Parisa Yavari, Thanh Ha Nguyen, William Briggs, David L Hare, John French, Steven Unger, Mark Richards, Anthony Keech, John D Horowitz, Michael Frenneaux, Bernard Prendergast, Jeremy S Dwight, Rajesh Kharbanda, Hugh Watkins, Houman Ashrafian, Julian L Griffin
doi: https://doi.org/10.1101/715680
Nikhil Pal
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
2Department of Experimental Therapeutics, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Animesh Acharjee
3Department of Biochemistry and Cambridge Systems Biology Centre, Research, University of Cambridge, UK
4MRC-Human Nutrition, Research, University of Cambridge, UK
5Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, B15 2TT, UK
Zsuzsanna Ament
3Department of Biochemistry and Cambridge Systems Biology Centre, Research, University of Cambridge, UK
4MRC-Human Nutrition, Research, University of Cambridge, UK
Tim Dent
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Arash Yavari
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
2Department of Experimental Therapeutics, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Masliza Mahmod
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Rina Ariga
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
James West
3Department of Biochemistry and Cambridge Systems Biology Centre, Research, University of Cambridge, UK
4MRC-Human Nutrition, Research, University of Cambridge, UK
Violetta Steeples
6Wellcome Trust Centre for Human Genetics (WTCHG), University of Oxford, Oxford OX3 7BN, UK
Mark Cassar
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Neil J. Howell
7Department of Cardiothoracic Surgery, University Hospital Birmingham, Edgbaston, Birmingham, UK
Helen Lockstone
6Wellcome Trust Centre for Human Genetics (WTCHG), University of Oxford, Oxford OX3 7BN, UK
Kate Elliott
6Wellcome Trust Centre for Human Genetics (WTCHG), University of Oxford, Oxford OX3 7BN, UK
Parisa Yavari
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Thanh Ha Nguyen
8Cardiology/Clinical Pharmacology Unit, Queen Elizabeth Hospital, University of Adelaide, Australia
William Briggs
3Department of Biochemistry and Cambridge Systems Biology Centre, Research, University of Cambridge, UK
David L Hare
9University of Melbourne, Austin Hospital, Australia
John French
8Cardiology/Clinical Pharmacology Unit, Queen Elizabeth Hospital, University of Adelaide, Australia
Steven Unger
10Liverpool Hospital, Sydney, Australia
Mark Richards
11University of Otago, Christchurch, New Zealand
Anthony Keech
12NHMRC Clinical trials Unit, University of Sydney
John D Horowitz
8Cardiology/Clinical Pharmacology Unit, Queen Elizabeth Hospital, University of Adelaide, Australia
Michael Frenneaux
13Norwich Medical School, University of East Anglia, Bob Champion Research and Educational Building, James Watson Road, Norwich Research Park, Norwich, NR4 7UQ
Bernard Prendergast
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Jeremy S Dwight
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Rajesh Kharbanda
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Hugh Watkins
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Houman Ashrafian
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
2Department of Experimental Therapeutics, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, UK
Julian L Griffin
3Department of Biochemistry and Cambridge Systems Biology Centre, Research, University of Cambridge, UK
4MRC-Human Nutrition, Research, University of Cambridge, UK
Article usage
Posted August 07, 2019.
Metabolic Profiling of Aortic Stenosis and Hypertrophic Cardiomyopathy Identifies Mechanistic Contrasts in Substrate Utilisation
Nikhil Pal, Animesh Acharjee, Zsuzsanna Ament, Tim Dent, Arash Yavari, Masliza Mahmod, Rina Ariga, James West, Violetta Steeples, Mark Cassar, Neil J. Howell, Helen Lockstone, Kate Elliott, Parisa Yavari, Thanh Ha Nguyen, William Briggs, David L Hare, John French, Steven Unger, Mark Richards, Anthony Keech, John D Horowitz, Michael Frenneaux, Bernard Prendergast, Jeremy S Dwight, Rajesh Kharbanda, Hugh Watkins, Houman Ashrafian, Julian L Griffin
bioRxiv 715680; doi: https://doi.org/10.1101/715680
Metabolic Profiling of Aortic Stenosis and Hypertrophic Cardiomyopathy Identifies Mechanistic Contrasts in Substrate Utilisation
Nikhil Pal, Animesh Acharjee, Zsuzsanna Ament, Tim Dent, Arash Yavari, Masliza Mahmod, Rina Ariga, James West, Violetta Steeples, Mark Cassar, Neil J. Howell, Helen Lockstone, Kate Elliott, Parisa Yavari, Thanh Ha Nguyen, William Briggs, David L Hare, John French, Steven Unger, Mark Richards, Anthony Keech, John D Horowitz, Michael Frenneaux, Bernard Prendergast, Jeremy S Dwight, Rajesh Kharbanda, Hugh Watkins, Houman Ashrafian, Julian L Griffin
bioRxiv 715680; doi: https://doi.org/10.1101/715680
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