Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Structure of the bacterial flagellar rotor MS-ring: a minimum inventory/maximum diversity system

Steven Johnson, Yu Hang Fong, Justin Deme, Emily Furlong, Lucas Kuhlen, Susan M. Lea
doi: https://doi.org/10.1101/718072
Steven Johnson
1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yu Hang Fong
1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Justin Deme
1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
2Central Oxford Structural Molecular Imaging Centre, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emily Furlong
1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lucas Kuhlen
1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susan M. Lea
1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
2Central Oxford Structural Molecular Imaging Centre, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: susan.lea@path.ox.ac.uk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

The bacterial flagellum is a complex, self-assembling, nanomachine that confers motility on the cell. Despite great variation across species, all flagella are ultimately constructed from a helical propellor attached to a motor embedded in the inner membrane. The motor consists of a series of stator units surrounding a central rotor made up of two ring complexes, the MS-ring and the C-ring. Despite many studies, high resolution structural information is still completely lacking for the MS-ring of the rotor, and proposed mismatches in stoichiometry between the two rings have long provided a source of confusion for the field. We here present structures of the Salmonella MS-ring, revealing an unprecedented level of inter- and intra-chain symmetry variation that provides a structural explanation for the ability of the MS-ring to function as a complex and elegant interface between the two main functions of the flagellum, protein secretion and rotation.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted July 30, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Structure of the bacterial flagellar rotor MS-ring: a minimum inventory/maximum diversity system
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Structure of the bacterial flagellar rotor MS-ring: a minimum inventory/maximum diversity system
Steven Johnson, Yu Hang Fong, Justin Deme, Emily Furlong, Lucas Kuhlen, Susan M. Lea
bioRxiv 718072; doi: https://doi.org/10.1101/718072
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Structure of the bacterial flagellar rotor MS-ring: a minimum inventory/maximum diversity system
Steven Johnson, Yu Hang Fong, Justin Deme, Emily Furlong, Lucas Kuhlen, Susan M. Lea
bioRxiv 718072; doi: https://doi.org/10.1101/718072

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Microbiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4381)
  • Biochemistry (9581)
  • Bioengineering (7086)
  • Bioinformatics (24844)
  • Biophysics (12597)
  • Cancer Biology (9951)
  • Cell Biology (14345)
  • Clinical Trials (138)
  • Developmental Biology (7944)
  • Ecology (12101)
  • Epidemiology (2067)
  • Evolutionary Biology (15984)
  • Genetics (10921)
  • Genomics (14732)
  • Immunology (9869)
  • Microbiology (23645)
  • Molecular Biology (9477)
  • Neuroscience (50838)
  • Paleontology (369)
  • Pathology (1539)
  • Pharmacology and Toxicology (2681)
  • Physiology (4013)
  • Plant Biology (8655)
  • Scientific Communication and Education (1508)
  • Synthetic Biology (2391)
  • Systems Biology (6427)
  • Zoology (1346)