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Mesolimbic dopamine D2 receptors and neural representations of subjective value

View ORCID ProfileJaime J. Castrellon, Jacob S. Young, View ORCID ProfileLinh C. Dang, Ronald L. Cowan, View ORCID ProfileDavid H. Zald, View ORCID ProfileGregory R. Samanez-Larkin
doi: https://doi.org/10.1101/718858
Jaime J. Castrellon
Department of Psychology and Neuroscience, Duke UniversityCenter for Cognitive Neuroscience, Duke University
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  • For correspondence: jjfcastrel@gmail.com
Jacob S. Young
Department of Neurological Surgery, University of California, San Francisco
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Linh C. Dang
Department of Psychology, Vanderbilt University
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Ronald L. Cowan
Department of Psychology, Vanderbilt UniversityDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University School of MedicineDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center
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David H. Zald
Department of Psychology, Vanderbilt UniversityDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine
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Gregory R. Samanez-Larkin
Department of Psychology and Neuroscience, Duke UniversityCenter for Cognitive Neuroscience, Duke University
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  • ORCID record for Gregory R. Samanez-Larkin
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Abstract

The process by which the value of delayed rewards is discounted varies from person to person. It has been suggested that these individual differences in subjective valuation of delayed rewards are supported by mesolimbic dopamine D2-like receptors (D2Rs) in the ventral striatum. However, no study to date has documented an association between direct measures of dopamine receptors and neural representations of subjective value in humans. Here, we examined whether individual differences in D2R availability were related to neural subjective value signals during decision making. Human participants completed a monetary delay discounting task during an fMRI scan and on a separate visit completed a PET scan with the high affinity D2R tracer [18F]fallypride. Region-of-interest analyses revealed that D2R availability in the ventral striatum was positively correlated with subjective value-related activity in the ventromedial prefrontal cortex and midbrain but not with choice behavior. Whole-brain analyses revealed a positive correlation between ventral striatum D2R availability and subjective value-related activity in the left inferior frontal gyrus. These findings are the first to identify a link between directly-measured mesolimbic dopamine function and subjective value representation in humans and suggest a mechanism by which individuals vary in neural representation of discounted subjective value.

Footnotes

  • Author Note: Some of the results reported in this manuscript were presented in a poster at the annual meeting of the Cognitive Neuroscience Society (2018) and the Society for Neuroeconomics (2018). Correspondence concerning this article should be addressed to Jaime Castrellon, Center for Cognitive Neuroscience, Duke University, Box 90999, Durham, NC 27708. Email: jaime.castrellon{at}duke.edu

  • Data Availability: Raw fMRI and PET data used in the manuscript can be viewed and downloaded from OpenNeuro (https://openneuro.org/datasets/ds002041). Unthresholded voxelwise statistical fMRI maps can be viewed and downloaded on NeuroVault (https://neurovault.org/collections/PDSRXDAH/). Data and code used in analyses can be viewed and downloaded on OSF (https://osf.io/6p4rk/).

  • https://openneuro.org/datasets/ds002041

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 01, 2019.
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Mesolimbic dopamine D2 receptors and neural representations of subjective value
Jaime J. Castrellon, Jacob S. Young, Linh C. Dang, Ronald L. Cowan, David H. Zald, Gregory R. Samanez-Larkin
bioRxiv 718858; doi: https://doi.org/10.1101/718858
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Mesolimbic dopamine D2 receptors and neural representations of subjective value
Jaime J. Castrellon, Jacob S. Young, Linh C. Dang, Ronald L. Cowan, David H. Zald, Gregory R. Samanez-Larkin
bioRxiv 718858; doi: https://doi.org/10.1101/718858

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