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Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease
View ORCID ProfileRichard J. Wheeler, Hyun O. Lee, Ina Poser, Arun Pal, Thom Doeleman, Satoshi Kishigami, Sukhleen Kour, Eric Nathaniel Anderson, Lara Marrone, Anastasia C. Murthy, Marcus Jahnel, Xaiojie Zhang, Edgar Boczek, Anatol Fritsch, Nicolas L. Fawzi, Jared Sterneckert, Udai Pandey, Della C. David, Benjamin G. Davis, Andrew J. Baldwin, Andreas Hermann, Marc Bickle, Simon Alberti, Anthony A. Hyman
doi: https://doi.org/10.1101/721001
Richard J. Wheeler
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, Germany
2Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, South Parks Road, Oxford, UK
Hyun O. Lee
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, Germany
3Biochemistry, University of Toronto, MaRS, West Tower, Suite 1501 661 University Avenue, Toronto, Ontario, Canada
Ina Poser
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, Germany
Arun Pal
4Department of Neurology, Technische Universität Dresden, Dresden, Germany
5Center for Regenerative Therapies (CRT), Dresden, Germany
Thom Doeleman
4Department of Neurology, Technische Universität Dresden, Dresden, Germany
5Center for Regenerative Therapies (CRT), Dresden, Germany
Satoshi Kishigami
6Department of Chemistry, University of Oxford, South Parks Road, Oxford, UK
Sukhleen Kour
7Division of Child Neurology, Department of Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
8Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
9Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Eric Nathaniel Anderson
7Division of Child Neurology, Department of Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
8Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
9Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Lara Marrone
5Center for Regenerative Therapies (CRT), Dresden, Germany
10Centre for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany
Anastasia C. Murthy
11Graduate Program in Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA
Marcus Jahnel
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, Germany
Xaiojie Zhang
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, Germany
Edgar Boczek
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, Germany
Anatol Fritsch
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, Germany
Nicolas L. Fawzi
12Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, USA
Jared Sterneckert
5Center for Regenerative Therapies (CRT), Dresden, Germany
10Centre for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany
Udai Pandey
7Division of Child Neurology, Department of Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
8Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
9Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Della C. David
13German Centre for Neurodegenerative Diseases, Otfried-Müller-Straße 23, Tübingen, Germany
Benjamin G. Davis
6Department of Chemistry, University of Oxford, South Parks Road, Oxford, UK
Andrew J. Baldwin
6Department of Chemistry, University of Oxford, South Parks Road, Oxford, UK
Andreas Hermann
13German Centre for Neurodegenerative Diseases, Otfried-Müller-Straße 23, Tübingen, Germany
15Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany
16German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, 18147 Rostock, Germany
Marc Bickle
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, Germany
Simon Alberti
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, Germany
17Dewpoint Therapeutics, Cambridge, MA 02139, USA
Anthony A. Hyman
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, Germany
17Dewpoint Therapeutics, Cambridge, MA 02139, USA
Article usage
Posted August 05, 2019.
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease
Richard J. Wheeler, Hyun O. Lee, Ina Poser, Arun Pal, Thom Doeleman, Satoshi Kishigami, Sukhleen Kour, Eric Nathaniel Anderson, Lara Marrone, Anastasia C. Murthy, Marcus Jahnel, Xaiojie Zhang, Edgar Boczek, Anatol Fritsch, Nicolas L. Fawzi, Jared Sterneckert, Udai Pandey, Della C. David, Benjamin G. Davis, Andrew J. Baldwin, Andreas Hermann, Marc Bickle, Simon Alberti, Anthony A. Hyman
bioRxiv 721001; doi: https://doi.org/10.1101/721001
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease
Richard J. Wheeler, Hyun O. Lee, Ina Poser, Arun Pal, Thom Doeleman, Satoshi Kishigami, Sukhleen Kour, Eric Nathaniel Anderson, Lara Marrone, Anastasia C. Murthy, Marcus Jahnel, Xaiojie Zhang, Edgar Boczek, Anatol Fritsch, Nicolas L. Fawzi, Jared Sterneckert, Udai Pandey, Della C. David, Benjamin G. Davis, Andrew J. Baldwin, Andreas Hermann, Marc Bickle, Simon Alberti, Anthony A. Hyman
bioRxiv 721001; doi: https://doi.org/10.1101/721001
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