Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Regenerative neurogenesis is induced from glia by Ia-2 driven neuron-glia communication

View ORCID ProfileNeale Harrison, Elizabeth Connolly, Alicia Gascón Gubieda, Zidan Yang, Benjamin Altenhein, Maria Losada-Perez, Marta Moreira, View ORCID ProfileAlicia Hidalgo
doi: https://doi.org/10.1101/721498
Neale Harrison
NeuroDevelopment Group, School of Biosciences, University of Birmingham, UKTomlinson Lab, School of Biosciences, University of Birmingham, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Neale Harrison
Elizabeth Connolly
NeuroDevelopment Group, School of Biosciences, University of Birmingham, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alicia Gascón Gubieda
NeuroDevelopment Group, School of Biosciences, University of Birmingham, UKInstitute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zidan Yang
NeuroDevelopment Group, School of Biosciences, University of Birmingham, UKMax Planck Florida Institute for Neuroscience,1 Max Planck Way, Jupiter, Florida 33458, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benjamin Altenhein
Institute of Zoology, University of Cologne, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Losada-Perez
Instituto Cajal, Consejo Superior de Investigaciones Cientificas (CSIC), Madrid, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marta Moreira
NeuroDevelopment Group, School of Biosciences, University of Birmingham, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alicia Hidalgo
NeuroDevelopment Group, School of Biosciences, University of Birmingham, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Alicia Hidalgo
  • For correspondence: a.hidalgo@bham.ac.uk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

ABSTRACT

A key goal to promote central nervous system regeneration is to discover mechanisms of injury-induced de novo neurogenesis. Glial cells might induce neurogenesis upon injury, but this is debated, and underlying mechanisms are unknown. A critical missing link is the identification of neuronal factors that could interact with glial NG2 to facilitate regeneration. Here, we used Drosophila genetics to search for neuronal partners of the NG2 homologue Kon-tiki (Kon), and identified Ia-2, involved in insulin secretion. Ia-2 is exclusively neuronal, and alterations in Ia-2 function destabilized cell fate. Injury increased ia-2 expression and induced neural stem cells. Using glial markers, genetic epistasis analysis and lineage tracing, we demonstrate that Ia-2 functions together with Kon and Dilp6 to induce de novo neural stem cells from glia. Altogether, Ia-2 and Kon initiate a neuron-glia interaction loop that coordinates de novo production of both neurons and glia for central nervous system regeneration.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted August 01, 2019.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Regenerative neurogenesis is induced from glia by Ia-2 driven neuron-glia communication
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Regenerative neurogenesis is induced from glia by Ia-2 driven neuron-glia communication
Neale Harrison, Elizabeth Connolly, Alicia Gascón Gubieda, Zidan Yang, Benjamin Altenhein, Maria Losada-Perez, Marta Moreira, Alicia Hidalgo
bioRxiv 721498; doi: https://doi.org/10.1101/721498
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Regenerative neurogenesis is induced from glia by Ia-2 driven neuron-glia communication
Neale Harrison, Elizabeth Connolly, Alicia Gascón Gubieda, Zidan Yang, Benjamin Altenhein, Maria Losada-Perez, Marta Moreira, Alicia Hidalgo
bioRxiv 721498; doi: https://doi.org/10.1101/721498

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (1546)
  • Biochemistry (2504)
  • Bioengineering (1759)
  • Bioinformatics (9734)
  • Biophysics (3930)
  • Cancer Biology (2996)
  • Cell Biology (4237)
  • Clinical Trials (135)
  • Developmental Biology (2657)
  • Ecology (4133)
  • Epidemiology (2033)
  • Evolutionary Biology (6937)
  • Genetics (5248)
  • Genomics (6534)
  • Immunology (2209)
  • Microbiology (7019)
  • Molecular Biology (2786)
  • Neuroscience (17431)
  • Paleontology (127)
  • Pathology (433)
  • Pharmacology and Toxicology (712)
  • Physiology (1069)
  • Plant Biology (2516)
  • Scientific Communication and Education (647)
  • Synthetic Biology (836)
  • Systems Biology (2700)
  • Zoology (439)