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Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity
Janice H. Xu, Jerome Eberhardt, Brianna Hill-Payne, Gonzalo E. González-Páez, José Omar Castellón, Benjamin F. Cravatt, View ORCID ProfileStefano Forli, View ORCID ProfileDennis W. Wolan, View ORCID ProfileKeriann M. Backus
doi: https://doi.org/10.1101/721951
Janice H. Xu
1Department of Molecular Medicine, The Scripps Research Institute, CA 92037, USA
2Department of Structural and Computational Biology, The Scripps Research Institute, CA 92037, USA
Jerome Eberhardt
2Department of Structural and Computational Biology, The Scripps Research Institute, CA 92037, USA
Brianna Hill-Payne
4Departments of Biological Chemistry and Chemistry and Biochemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Gonzalo E. González-Páez
1Department of Molecular Medicine, The Scripps Research Institute, CA 92037, USA
2Department of Structural and Computational Biology, The Scripps Research Institute, CA 92037, USA
José Omar Castellón
4Departments of Biological Chemistry and Chemistry and Biochemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Benjamin F. Cravatt
3Department of Chemistry, The Scripps Research Institute, CA 92037, USA
Stefano Forli
2Department of Structural and Computational Biology, The Scripps Research Institute, CA 92037, USA
Dennis W. Wolan
1Department of Molecular Medicine, The Scripps Research Institute, CA 92037, USA
2Department of Structural and Computational Biology, The Scripps Research Institute, CA 92037, USA
Keriann M. Backus
4Departments of Biological Chemistry and Chemistry and Biochemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Posted August 05, 2019.
Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity
Janice H. Xu, Jerome Eberhardt, Brianna Hill-Payne, Gonzalo E. González-Páez, José Omar Castellón, Benjamin F. Cravatt, Stefano Forli, Dennis W. Wolan, Keriann M. Backus
bioRxiv 721951; doi: https://doi.org/10.1101/721951
Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity
Janice H. Xu, Jerome Eberhardt, Brianna Hill-Payne, Gonzalo E. González-Páez, José Omar Castellón, Benjamin F. Cravatt, Stefano Forli, Dennis W. Wolan, Keriann M. Backus
bioRxiv 721951; doi: https://doi.org/10.1101/721951
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