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Chance and Necessity in the Pleiotropic Consequences of Adaptation for Budding Yeast

Elizabeth R. Jerison, Alex N. Nguyen Ba, Michael M. Desai, View ORCID ProfileSergey Kryazhimskiy
doi: https://doi.org/10.1101/724617
Elizabeth R. Jerison
1Department of Physics, Harvard University, Cambridge MA 02138, USA
2Department of Organismic and Evolutionary Biology, Harvard University, Cambridge MA 02138, USA
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Alex N. Nguyen Ba
2Department of Organismic and Evolutionary Biology, Harvard University, Cambridge MA 02138, USA
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Michael M. Desai
1Department of Physics, Harvard University, Cambridge MA 02138, USA
2Department of Organismic and Evolutionary Biology, Harvard University, Cambridge MA 02138, USA
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  • For correspondence: mdesai@oeb.harvard.edu skryazhi@ucsd.edu
Sergey Kryazhimskiy
3Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
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  • ORCID record for Sergey Kryazhimskiy
  • For correspondence: mdesai@oeb.harvard.edu skryazhi@ucsd.edu
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Abstract

Mutations that a population accumulates during evolution in one (“home”) environment may cause fitness gains or losses in other conditions. Such pleiotropic fitness effects determine the evolutionary fate of the population in variable environments and can lead to ecological specialization. It is unclear how the pleiotropic outcomes of evolution are shaped by the intrinsic randomness of the evolutionary process and by the deterministic variation in selection pressures across environments. To address this question, we evolved 20 replicate populations of the yeast Saccharomyces cerevisiae in 11 laboratory environments and measured their fitness across multiple other conditions. We found that evolution in all home environments led to a diversity of patterns of pleiotropic fitness gains and losses, driven by multiple types of mutations. Approximately 60% percent of this variation are explained by clone’s home environment and the most common parallel genetic changes, while about 40% are attributed to the stochastic accumulation of mutations whose pleiotropic effects are unpredictable. On average, populations specialized to their home environment, but generalists also evolved in almost all conditions. Our results suggest that the mutations accumulating in a home environment incur a variety of pleiotropic effects, from costs to benefits, with different probabilities. Therefore, whether a population evolves towards a specialist or a generalist phenotype is heavily influenced by chance.

Footnotes

  • In this revised version, we quantified the contributions of chance and necessity to the pleiotropic outcomes of adaptation. We also expanded the introduction and discussion to connect the paper better with the field of evolutionary ecology.

  • https://github.com/erjerison/pleiotropy

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 27, 2019.
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Chance and Necessity in the Pleiotropic Consequences of Adaptation for Budding Yeast
Elizabeth R. Jerison, Alex N. Nguyen Ba, Michael M. Desai, Sergey Kryazhimskiy
bioRxiv 724617; doi: https://doi.org/10.1101/724617
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Chance and Necessity in the Pleiotropic Consequences of Adaptation for Budding Yeast
Elizabeth R. Jerison, Alex N. Nguyen Ba, Michael M. Desai, Sergey Kryazhimskiy
bioRxiv 724617; doi: https://doi.org/10.1101/724617

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