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Positively selected variants in functionally important regions of TLR7 in Alouatta guariba clamitans with yellow fever virus exposure in Northern Argentina

View ORCID ProfileNicole S. Torosin, View ORCID ProfileTimothy H. Webster, Hernan Argibay, Hebe Ferreyra, Marcela Uhart, Ilaria Agostini, Leslie A. Knapp
doi: https://doi.org/10.1101/725333
Nicole S. Torosin
1Department of Anthropology, University of Utah, 260 S. Central Campus Dr., Salt Lake City, UT 84112
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  • For correspondence: ntorosin@gmail.com
Timothy H. Webster
1Department of Anthropology, University of Utah, 260 S. Central Campus Dr., Salt Lake City, UT 84112
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Hernan Argibay
2Instituto de Ecología, Genética y Evolución de Buenos Aires (IEGEBA-CONICET), Intendente Güiraldes 2160 - Ciudad Universitaria (C1428EGA) Ciudad Autónoma de Buenos Aires, Argentina
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Hebe Ferreyra
3Global Health Program, Wildlife Conservation Society, Buenos Aires, Argentina
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Marcela Uhart
4One Health Institute, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, VM3B, Davis, California 95616, USA
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Ilaria Agostini
5Instituto de Biología Subtropical (IBS), Universidad Nacional de Misiones (UNaM), Consejo Nacional de Investigaciones Científcas y Técnicas (CON-ICET), Puerto Iguazú, Misiones, Argentina
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Leslie A. Knapp
1Department of Anthropology, University of Utah, 260 S. Central Campus Dr., Salt Lake City, UT 84112
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1 Abstract

In 2007-2009, a ma jor yellow fever virus (YFV) outbreak in Northern Argentina decimated the local howler monkey (Alouatta) population. We explored the relationship between Toll-like receptor (TLR) 7 and TLR8 gene variation and YFV susceptibility using samples from Alouatta individuals alive before the YFV outbreak, individuals that died during the outbreak, and individuals that survived the outbreak and are alive today. We measured genetic divergence between Alouatta YFV exposure groups and evaluated Alouatta-specific substitutions for functional consequences. We did not find different allele frequencies in the post-YFV exposure Alouatta group compared to the pre-exposure group. However, we identified three nonsynonymous variants in TLR7 in A. guariba clamitans. Two of these substitutions are under positive selection in functionally important regions of the gene. These unique coding differences in A. guariba clamitans may affect YFV resistance, but more work is necessary to fully explore this hypothesis.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 05, 2019.
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Positively selected variants in functionally important regions of TLR7 in Alouatta guariba clamitans with yellow fever virus exposure in Northern Argentina
Nicole S. Torosin, Timothy H. Webster, Hernan Argibay, Hebe Ferreyra, Marcela Uhart, Ilaria Agostini, Leslie A. Knapp
bioRxiv 725333; doi: https://doi.org/10.1101/725333
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Positively selected variants in functionally important regions of TLR7 in Alouatta guariba clamitans with yellow fever virus exposure in Northern Argentina
Nicole S. Torosin, Timothy H. Webster, Hernan Argibay, Hebe Ferreyra, Marcela Uhart, Ilaria Agostini, Leslie A. Knapp
bioRxiv 725333; doi: https://doi.org/10.1101/725333

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