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A role for astroglial calcium in mammalian sleep

View ORCID ProfileAshley M. Ingiosi, Christopher R. Hayworth, Daniel O. Harvey, Kristan G. Singletary, Michael J. Rempe, Jonathan P. Wisor, Marcos G. Frank
doi: https://doi.org/10.1101/728931
Ashley M. Ingiosi
1Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
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  • ORCID record for Ashley M. Ingiosi
Christopher R. Hayworth
1Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
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Daniel O. Harvey
1Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
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Kristan G. Singletary
1Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
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Michael J. Rempe
1Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
2Mathematics and Computer Science, Whitworth University, Spokane, WA, USA
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Jonathan P. Wisor
1Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
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Marcos G. Frank
1Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
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  • For correspondence: marcos.frank@wsu.edu
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Abstract

Mammalian sleep is characterized by dramatic changes in neuronal activity, and waking neuronal activity is thought to increase sleep need. Changes in other brain cells (glia) across the natural sleep-wake cycle and their role in sleep regulation are comparatively unexplored. We show that sleep is also accompanied by large changes in astroglial activity as measured by intracellular calcium concentrations in unanesthetized mice. These changes in calcium vary across different vigilance states and are most pronounced in distal astroglial processes. We find that reducing intracellular calcium in astrocytes impaired the homeostatic response to sleep deprivation. Thus, astroglial calcium changes dynamically across vigilance states and is a component of the sleep homeostat.

One Sentence Summary Astroglial calcium concentrations vary with sleep and wake, change after sleep deprivation, and mediate sleep need.

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Posted August 08, 2019.
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A role for astroglial calcium in mammalian sleep
Ashley M. Ingiosi, Christopher R. Hayworth, Daniel O. Harvey, Kristan G. Singletary, Michael J. Rempe, Jonathan P. Wisor, Marcos G. Frank
bioRxiv 728931; doi: https://doi.org/10.1101/728931
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A role for astroglial calcium in mammalian sleep
Ashley M. Ingiosi, Christopher R. Hayworth, Daniel O. Harvey, Kristan G. Singletary, Michael J. Rempe, Jonathan P. Wisor, Marcos G. Frank
bioRxiv 728931; doi: https://doi.org/10.1101/728931

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