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Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
View ORCID ProfileGabriella T. Heller, View ORCID ProfileFrancesco A. Aprile, View ORCID ProfileThomas C. T. Michaels, View ORCID ProfileRyan Limbocker, View ORCID ProfileMichele Perni, View ORCID ProfileFrancesco Simone Ruggeri, View ORCID ProfileBenedetta Mannini, View ORCID ProfileThomas Löhr, View ORCID ProfileMassimiliano Bonomi, View ORCID ProfileAlfonso De Simone, View ORCID ProfileIsabella C. Felli, View ORCID ProfileRoberta Pierattelli, View ORCID ProfileTuomas P. J. Knowles, View ORCID ProfileChristopher M. Dobson, View ORCID ProfileMichele Vendruscolo
doi: https://doi.org/10.1101/729392
Gabriella T. Heller
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Francesco A. Aprile
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Thomas C. T. Michaels
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
2Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge MA, USA
Ryan Limbocker
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Michele Perni
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Francesco Simone Ruggeri
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Benedetta Mannini
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Thomas Löhr
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Massimiliano Bonomi
3Structural Bioinformatics Unit, Institut Pasteur, CNRS UMR 3528, 75015 Paris, France
Alfonso De Simone
4Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK
Isabella C. Felli
5Magnetic Resonance Center (CERM), University of Florence, 50019 Sesto Fiorentino, Italy
6Department of Chemistry “Ugo Schiff”, University of Florence, 50019 Sesto Fiorentino, Italy
Roberta Pierattelli
5Magnetic Resonance Center (CERM), University of Florence, 50019 Sesto Fiorentino, Italy
6Department of Chemistry “Ugo Schiff”, University of Florence, 50019 Sesto Fiorentino, Italy
Tuomas P. J. Knowles
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Christopher M. Dobson
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Michele Vendruscolo
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Posted August 08, 2019.
Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
Gabriella T. Heller, Francesco A. Aprile, Thomas C. T. Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Alfonso De Simone, Isabella C. Felli, Roberta Pierattelli, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo
bioRxiv 729392; doi: https://doi.org/10.1101/729392
Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
Gabriella T. Heller, Francesco A. Aprile, Thomas C. T. Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Alfonso De Simone, Isabella C. Felli, Roberta Pierattelli, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo
bioRxiv 729392; doi: https://doi.org/10.1101/729392
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