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Rapid Sensorimotor Reinforcement in the Olfactory Striatum

View ORCID ProfileDaniel J. Millman, View ORCID ProfileVenkatesh N. Murthy
doi: https://doi.org/10.1101/730697
Daniel J. Millman
1Graduate Program in Neuroscience, Harvard University
2Department of Molecular & Cellular Biology, Harvard University
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Venkatesh N. Murthy
2Department of Molecular & Cellular Biology, Harvard University
3Center for Brain Science, Harvard University
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  • For correspondence: vnmurthy@fas.harvard.edu
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Abstract

Rodents can successfully learn multiple, novel stimulus-response associations after only a few repetitions when the contingencies predict reward. The circuits modified during such reinforcement learning to support decision making are not known, but the olfactory tubercle (OT) and posterior piriform cortex (pPC) are candidates for decoding reward category from olfactory sensory input and relaying this information to cognitive and motor areas. Here, we show that an explicit representation for reward category emerges in the OT within minutes of learning a novel odor-reward association, whereas the pPC lacks an explicit representation even after weeks of overtraining. The explicit reward category representation in OT is visible in the first sniff (50-100ms) of an odor on each trial, and precedes the motor action. Together, these results suggest that coding of stimulus information required for reward prediction does not occur within olfactory cortex, but rather in circuits involving the olfactory striatum.

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  • ↵† Allen Institute for Brain Science, Seattle, WA

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 09, 2019.
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Rapid Sensorimotor Reinforcement in the Olfactory Striatum
Daniel J. Millman, Venkatesh N. Murthy
bioRxiv 730697; doi: https://doi.org/10.1101/730697
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Rapid Sensorimotor Reinforcement in the Olfactory Striatum
Daniel J. Millman, Venkatesh N. Murthy
bioRxiv 730697; doi: https://doi.org/10.1101/730697

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