Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Low rank mechanisms underlying flexible visual representations

View ORCID ProfileDouglas A. Ruff, Cheng Xue, Lily E. Kramer, Faisal Baqai, Marlene R. Cohen
doi: https://doi.org/10.1101/730978
Douglas A. Ruff
1Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Douglas A. Ruff
  • For correspondence: douglas.ruff@gmail.com
Cheng Xue
1Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lily E. Kramer
1Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Faisal Baqai
2Program in Neural Computation, Carnegie Mellon University, Pittsburgh, PA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marlene R. Cohen
1Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA
2Program in Neural Computation, Carnegie Mellon University, Pittsburgh, PA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Neuronal population responses to sensory stimuli are remarkably flexible. The responses of neurons in visual cortex depend on stimulus properties (e.g. contrast), processes that affect all stages of visual processing (e.g. adaptation), and cognitive processes (e.g attention or task switching). The effects of all of these processes on trial-averaged responses of individual neurons are well-described by divisive normalization, in which responses are scaled by the total stimulus drive. Normalization describes how a staggering variety of sensory, cognitive, and motor processes affect individual neurons (1), but whether different normalization processes could be mediated by the same mechanism remains poorly understood. We and others recently showed that attention has low rank effects on the covariability of populations of neurons in visual area V4 (2–4), which strongly constrains mechanistic models mechanism (2). We hypothesized that measuring changes in population covariability associated with other normalization processes could clarify whether they might share a mechanism. Our experimental design included measurements in multiple visual areas using four normalization processes. We found that contrast, adaptation, attention, and task switching affect the responses of populations of neurons in primate visual cortex in a similarly low rank way. These results suggest that a given circuit uses a common mechanism to perform many forms of normalization and likely reflect a general principle that applies to a wide range of brain areas and sensory, cognitive, or motor processes.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted August 09, 2019.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Low rank mechanisms underlying flexible visual representations
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Low rank mechanisms underlying flexible visual representations
Douglas A. Ruff, Cheng Xue, Lily E. Kramer, Faisal Baqai, Marlene R. Cohen
bioRxiv 730978; doi: https://doi.org/10.1101/730978
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Low rank mechanisms underlying flexible visual representations
Douglas A. Ruff, Cheng Xue, Lily E. Kramer, Faisal Baqai, Marlene R. Cohen
bioRxiv 730978; doi: https://doi.org/10.1101/730978

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4119)
  • Biochemistry (8828)
  • Bioengineering (6532)
  • Bioinformatics (23484)
  • Biophysics (11805)
  • Cancer Biology (9223)
  • Cell Biology (13336)
  • Clinical Trials (138)
  • Developmental Biology (7442)
  • Ecology (11425)
  • Epidemiology (2066)
  • Evolutionary Biology (15173)
  • Genetics (10453)
  • Genomics (14056)
  • Immunology (9187)
  • Microbiology (22199)
  • Molecular Biology (8823)
  • Neuroscience (47626)
  • Paleontology (351)
  • Pathology (1431)
  • Pharmacology and Toxicology (2493)
  • Physiology (3736)
  • Plant Biology (8090)
  • Scientific Communication and Education (1438)
  • Synthetic Biology (2224)
  • Systems Biology (6042)
  • Zoology (1254)