Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

The circulating lipidome is largely defined by sex descriptors in the GOLDN, GeneBank and the ADNI studies

Dinesh Kumar Barupal, Ying Zhang, Sili Fan, Stanley L. Hazen, W. H. Wilson Tang, Tomas Cajka, Marguerite R. Irvin, Donna K. Arnett, Tobias Kind, Rima Kaddurah-Daouk, Oliver Fiehn
doi: https://doi.org/10.1101/731448
Dinesh Kumar Barupal
1West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis, 451 Health Sciences Drive, Davis, California 95616, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ying Zhang
1West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis, 451 Health Sciences Drive, Davis, California 95616, USA
2Chemistry Department, University of California, Davis, California 95616, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sili Fan
1West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis, 451 Health Sciences Drive, Davis, California 95616, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stanley L. Hazen
7Department of Cellular & Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
8Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W. H. Wilson Tang
7Department of Cellular & Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
8Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tomas Cajka
6Department of Metabolomics and Department of Translational Metabolism, Institute of Physiology CAS, Prague, Czech Republic
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marguerite R. Irvin
4Department of Epidemiology, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, Alabama, 35294, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Donna K. Arnett
3College of Public Health, University of Kentucky, Lexington, 121 Washington Ave, Kentucky, 40536, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tobias Kind
1West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis, 451 Health Sciences Drive, Davis, California 95616, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rima Kaddurah-Daouk
5Department of Medicine and the Duke Institute for Brain Sciences, Duke University, Durham, NC, 27708 USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Oliver Fiehn
1West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis, 451 Health Sciences Drive, Davis, California 95616, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: ofiehn@ucdavis.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Biological sex is one of the major anthropometric factors which influences physiology, metabolism and health status. We have investigated the effect of sexual dimorphism on the blood lipidome profile in three large population level studies - the Alzheimer’s disease neuroimaging initiative - ADNI (n =806), the GeneBank Functional Cardio-Metabolomics cohort (n= 1015) and the Genetics of Lipid lowering Drugs and Diet Network - GOLDN (n=422). In total, 355 unique lipids from 15 lipid classes were detected across all three studies using LC-MS. Sixty percent of these lipids differed between men and women in all three cohorts, and up to 87% of all lipids demonstrated sex differences in at least one cohort. ChemRICH enrichment statistics on lipid classes showed that phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols, ceramides, sphingomyelins and cholesterol esters were found at higher levels in female subjects while triacylglycerols and lysophosphatidylcholines were found at higher levels in male participants across the three cohorts. This strong sex effect on the blood lipidome suggests that specific regulatory mechanisms may exist that regulate lipid metabolism in a different manner between men and women. Cohort studies involving blood lipidomics should consider separate analyses for male and female participants instead of combined analyses treating sex as a confounding factor.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted August 10, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
The circulating lipidome is largely defined by sex descriptors in the GOLDN, GeneBank and the ADNI studies
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
The circulating lipidome is largely defined by sex descriptors in the GOLDN, GeneBank and the ADNI studies
Dinesh Kumar Barupal, Ying Zhang, Sili Fan, Stanley L. Hazen, W. H. Wilson Tang, Tomas Cajka, Marguerite R. Irvin, Donna K. Arnett, Tobias Kind, Rima Kaddurah-Daouk, Oliver Fiehn
bioRxiv 731448; doi: https://doi.org/10.1101/731448
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
The circulating lipidome is largely defined by sex descriptors in the GOLDN, GeneBank and the ADNI studies
Dinesh Kumar Barupal, Ying Zhang, Sili Fan, Stanley L. Hazen, W. H. Wilson Tang, Tomas Cajka, Marguerite R. Irvin, Donna K. Arnett, Tobias Kind, Rima Kaddurah-Daouk, Oliver Fiehn
bioRxiv 731448; doi: https://doi.org/10.1101/731448

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Biochemistry
Subject Areas
All Articles
  • Animal Behavior and Cognition (4686)
  • Biochemistry (10364)
  • Bioengineering (7685)
  • Bioinformatics (26353)
  • Biophysics (13540)
  • Cancer Biology (10704)
  • Cell Biology (15447)
  • Clinical Trials (138)
  • Developmental Biology (8504)
  • Ecology (12828)
  • Epidemiology (2067)
  • Evolutionary Biology (16869)
  • Genetics (11405)
  • Genomics (15487)
  • Immunology (10630)
  • Microbiology (25227)
  • Molecular Biology (10225)
  • Neuroscience (54513)
  • Paleontology (402)
  • Pathology (1670)
  • Pharmacology and Toxicology (2898)
  • Physiology (4346)
  • Plant Biology (9258)
  • Scientific Communication and Education (1587)
  • Synthetic Biology (2558)
  • Systems Biology (6785)
  • Zoology (1469)