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Predicting the global mammalian viral sharing network using phylogeography

View ORCID ProfileGregory F Albery, View ORCID ProfileEvan A Eskew, View ORCID ProfileNoam Ross, View ORCID ProfileKevin J Olival
doi: https://doi.org/10.1101/732255
Gregory F Albery
1EcoHealth Alliance, New York, NY, USA
2Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland
3Department of Biology, Georgetown University, Washington, DC, USA
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  • For correspondence: gfalbery@gmail.com olival@ecohealthalliance.org
Evan A Eskew
1EcoHealth Alliance, New York, NY, USA
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Noam Ross
1EcoHealth Alliance, New York, NY, USA
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Kevin J Olival
1EcoHealth Alliance, New York, NY, USA
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  • For correspondence: gfalbery@gmail.com olival@ecohealthalliance.org
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Abstract

Understanding interspecific viral transmission is key to understanding viral ecology and evolution, disease spillover into humans, and the consequences of global change. Prior work has demonstrated that macroecological factors drive viral sharing in some mammalian groups, but analyses have never attempted to predict viral sharing in a pan-mammalian context. Here we show that host phylogenetic similarity and geographic range overlap are strong, nonlinear predictors of viral sharing among species across the entire mammal class. Using these traits, we predict global viral sharing patterns across 4196 mammal species and show that our simulated network successfully predicts viral sharing and reservoir host status using internal validation and an external dataset. We predict high rates of mammalian viral sharing in the tropics, particularly among rodents and bats, and that within- and between-order sharing differs geographically and taxonomically. Our results emphasize the importance of macroecological factors in shaping mammalian viral communities, and provide a robust, general model to predict viral host range and guide pathogen surveillance and conservation efforts.

Footnotes

  • Revisions for resubmission

  • https://github.com/gfalbery/ViralSharingPhylogeography

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 24, 2020.
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Predicting the global mammalian viral sharing network using phylogeography
Gregory F Albery, Evan A Eskew, Noam Ross, Kevin J Olival
bioRxiv 732255; doi: https://doi.org/10.1101/732255
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Predicting the global mammalian viral sharing network using phylogeography
Gregory F Albery, Evan A Eskew, Noam Ross, Kevin J Olival
bioRxiv 732255; doi: https://doi.org/10.1101/732255

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