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A mechanistic view of collective filament motion in active nematic networks

Moritz Striebel, View ORCID ProfileIsabella R. Graf, View ORCID ProfileErwin Frey
doi: https://doi.org/10.1101/732909
Moritz Striebel
Arnold Sommerfeld Center for Theoretical Physics (ASC) and Center for NanoScience (CeNS), Department of Physics, Ludwig-Maximilians-Universität München, Theresienstraße 37, 80333 München, Germany
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Isabella R. Graf
Arnold Sommerfeld Center for Theoretical Physics (ASC) and Center for NanoScience (CeNS), Department of Physics, Ludwig-Maximilians-Universität München, Theresienstraße 37, 80333 München, Germany
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Erwin Frey
Arnold Sommerfeld Center for Theoretical Physics (ASC) and Center for NanoScience (CeNS), Department of Physics, Ludwig-Maximilians-Universität München, Theresienstraße 37, 80333 München, Germany
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  • For correspondence: frey@lmu.de
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ABSTRACT

Protein filament networks are structures crucial for force generation and cell shape. A central open question is how collective filament dynamics emerges from interactions between individual network constituents. To address this question we study a minimal but generic model for a nematic network where filament sliding is driven by the action of motor proteins. Our theoretical analysis shows how the interplay between viscous drag on filaments and motor-induced forces governs force propagation through such interconnected filament networks. We find that the ratio between these antagonistic forces establishes the range of filament interaction, which determines how the local filament velocity depends on the polarity of the surrounding network. This force propagation mechanism implies that the polarity-independent sliding observed in Xenopus egg extracts, and in-vitro experiments with purified components, is a consequence of a large force propagation length. We suggest how our predictions can be tested by tangible in vitro experiments whose feasibility is assessed with the help of simulations and an accompanying theoretical analysis.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted August 13, 2019.
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A mechanistic view of collective filament motion in active nematic networks
Moritz Striebel, Isabella R. Graf, Erwin Frey
bioRxiv 732909; doi: https://doi.org/10.1101/732909
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A mechanistic view of collective filament motion in active nematic networks
Moritz Striebel, Isabella R. Graf, Erwin Frey
bioRxiv 732909; doi: https://doi.org/10.1101/732909

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