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Acoustic biomolecules enhance hemodynamic functional ultrasound imaging of neural activity

View ORCID ProfileDavid Maresca, Thomas Payen, View ORCID ProfileAudrey Lee-Gosselin, Bill Ling, View ORCID ProfileDina Malounda, View ORCID ProfileCharlie Demené, View ORCID ProfileMickaël Tanter, View ORCID ProfileMikhail G. Shapiro
doi: https://doi.org/10.1101/734939
David Maresca
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA
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Thomas Payen
Physics for Medicine Paris, INSERM, CNRS, ESPCI, Paris, France
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Audrey Lee-Gosselin
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA
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Bill Ling
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA
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Dina Malounda
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA
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Charlie Demené
Physics for Medicine Paris, INSERM, CNRS, ESPCI, Paris, France
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Mickaël Tanter
Physics for Medicine Paris, INSERM, CNRS, ESPCI, Paris, France
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Mikhail G. Shapiro
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA
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  • For correspondence: mikhail@caltech.edu
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ABSTRACT

Hemodynamic functional ultrasound imaging (fUS) of neural activity provides a unique combination of spatial coverage, spatiotemporal resolution and compatibility with freely moving animals. However, deep and transcranial monitoring of brain activity and the imaging of dynamics in slow-flowing blood vessels remains challenging. To enhance fUS capabilities, we introduce biomolecular hemodynamic enhancers based on gas vesicles (GVs), genetically encodable ultrasound contrast agents derived from buoyant photosynthetic microorganisms. We show that intravenously infused GVs enhance ultrafast Doppler ultrasound contrast and visually-evoked hemodynamic contrast in transcranial fUS of the mouse brain. This hemodynamic contrast enhancement is smoother than that provided by conventional microbubbles, allowing GVs to more reliably amplify neuroimaging signals.

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Posted August 15, 2019.
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Acoustic biomolecules enhance hemodynamic functional ultrasound imaging of neural activity
David Maresca, Thomas Payen, Audrey Lee-Gosselin, Bill Ling, Dina Malounda, Charlie Demené, Mickaël Tanter, Mikhail G. Shapiro
bioRxiv 734939; doi: https://doi.org/10.1101/734939
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Acoustic biomolecules enhance hemodynamic functional ultrasound imaging of neural activity
David Maresca, Thomas Payen, Audrey Lee-Gosselin, Bill Ling, Dina Malounda, Charlie Demené, Mickaël Tanter, Mikhail G. Shapiro
bioRxiv 734939; doi: https://doi.org/10.1101/734939

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