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Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium

View ORCID ProfileAnders M. Fjell, Øystein Sørensen, View ORCID ProfileInge K. Amlien, David Bartrés-Faz, Didac Maciá Bros, Ilja Demuth, Christian A Drevon, Sandra Düzel, Klaus P. Ebmeier, Ane-Victoria Idland, Tim C. Kietzmann, Rogier Kievit, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Darren Price, Claire E. Sexton, Cristina Solé-Padullés, Sara Pudas, Donatas Sederevicius, Sana Suri, Gerd Wagner, Leiv Otto Watne, René Westerhausen, Enikő Zsoldos, Kristine B. Walhovd
doi: https://doi.org/10.1101/737858
Anders M. Fjell
1Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway
2Department of Radiology and Nuclear Medicine, Oslo University Hospital, Norway
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  • ORCID record for Anders M. Fjell
  • For correspondence: andersmf@psykologi.uio.no
Øystein Sørensen
1Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway
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Inge K. Amlien
1Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway
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  • ORCID record for Inge K. Amlien
David Bartrés-Faz
3Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain
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Didac Maciá Bros
3Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain
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Ilja Demuth
4Lipid Clinic, Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, Germany
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Christian A Drevon
5Vitas AS, Research Park, Gaustadalleen 21, 0349, Oslo and 6 University of Oslo, Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, Medicine/University of Oslo, Norway
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Sandra Düzel
6Max Planck Institute for Human Development, Germany
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Klaus P. Ebmeier
7Department of Psychiatry, University of Oxford, United Kingdom
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Ane-Victoria Idland
1Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway
8Oslo Delirium Research Group, Department of Geriatric Medicine, University of Oslo, Norway
9Institute of Basic Medical Sciences, University of Oslo, Norway
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Tim C. Kietzmann
10MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom
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Rogier Kievit
10MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom
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Simone Kühn
6Max Planck Institute for Human Development, Germany
11Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Germany
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Ulman Lindenberger
6Max Planck Institute for Human Development, Germany
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Athanasia M Mowinckel
1Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway
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Lars Nyberg
12Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden
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Darren Price
10MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom
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Claire E. Sexton
7Department of Psychiatry, University of Oxford, United Kingdom
13Global Brain Health Institute, Department of Neurology, University of California San Francisco, California, USA
14Wellcome Centre for Integrative Neuroimaging, University of Oxford, United Kingdom
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Cristina Solé-Padullés
3Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain
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Sara Pudas
12Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden
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Donatas Sederevicius
1Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway
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Sana Suri
7Department of Psychiatry, University of Oxford, United Kingdom
14Wellcome Centre for Integrative Neuroimaging, University of Oxford, United Kingdom
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Gerd Wagner
15Psychiatric Brain and Body Research Group, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
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Leiv Otto Watne
8Oslo Delirium Research Group, Department of Geriatric Medicine, University of Oslo, Norway
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René Westerhausen
1Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway
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Enikő Zsoldos
7Department of Psychiatry, University of Oxford, United Kingdom
14Wellcome Centre for Integrative Neuroimaging, University of Oxford, United Kingdom
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Kristine B. Walhovd
1Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway
2Department of Radiology and Nuclear Medicine, Oslo University Hospital, Norway
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Abstract

Background Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal atrophy is typically seen with higher age. Hence, it is critical to establish how the relationship between sleep and hippocampal volume loss unfolds across the adult lifespan.

Methods Self-reported sleep measures and MRI-derived hippocampal volumes were obtained from 3105 cognitively normal participants (18-90 years) from major European brain studies in the Lifebrain consortium. Hippocampal volume change was estimated from 5116 MRIs from 1299 participants, covering up to 11 years. Cross-sectional analyses were repeated in a sample of 21390 participants from the UK Biobank.

Results The relationship between self-reported sleep and age differed across sleep items. Sleep duration, efficiency, problems, and use of medication worsened monotonously with age, whereas subjective sleep quality, sleep latency, and daytime tiredness improved. Women reported worse sleep in general than men, but the relationship to age was similar. No cross-sectional sleep – hippocampal volume relationships was found. However, worse sleep quality, efficiency, problems, and daytime tiredness were related to greater hippocampal volume loss over time, with high scorers showing on average 0.22% greater annual loss than low scorers. Simulations showed that longitudinal effects were too small to be detected as age-interactions in cross-sectional analyses.

Conclusions Worse self-reported sleep is associated with higher rates of hippocampal decline across the adult lifespan. This suggests that sleep is relevant to understand individual differences in hippocampal atrophy, but limited effect sizes call for cautious interpretation.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 19, 2019.
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Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium
Anders M. Fjell, Øystein Sørensen, Inge K. Amlien, David Bartrés-Faz, Didac Maciá Bros, Ilja Demuth, Christian A Drevon, Sandra Düzel, Klaus P. Ebmeier, Ane-Victoria Idland, Tim C. Kietzmann, Rogier Kievit, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Darren Price, Claire E. Sexton, Cristina Solé-Padullés, Sara Pudas, Donatas Sederevicius, Sana Suri, Gerd Wagner, Leiv Otto Watne, René Westerhausen, Enikő Zsoldos, Kristine B. Walhovd
bioRxiv 737858; doi: https://doi.org/10.1101/737858
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Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium
Anders M. Fjell, Øystein Sørensen, Inge K. Amlien, David Bartrés-Faz, Didac Maciá Bros, Ilja Demuth, Christian A Drevon, Sandra Düzel, Klaus P. Ebmeier, Ane-Victoria Idland, Tim C. Kietzmann, Rogier Kievit, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Darren Price, Claire E. Sexton, Cristina Solé-Padullés, Sara Pudas, Donatas Sederevicius, Sana Suri, Gerd Wagner, Leiv Otto Watne, René Westerhausen, Enikő Zsoldos, Kristine B. Walhovd
bioRxiv 737858; doi: https://doi.org/10.1101/737858

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