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Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality
Hang Zhou, Julia M. Sealock, Sandra Sanchez-Roige, Toni-Kim Clarke, Daniel Levey, Zhongshan Cheng, Boyang Li, Renato Polimanti, Rachel L. Kember, Rachel Vickers Smith, Johan H. Thygesen, Marsha Y. Morgan, Stephen R. Atkinson, Mark R. Thursz, Mette Nyegaard, Manuel Mattheisen, Anders D. Børglum, Emma C. Johnson, the VA Million Veteran Program, Amy C. Justice, Abraham A. Palmer, Andrew McQuillin, Lea K. Davis, Howard J. Edenberg, Arpana Agrawal, Henry R. Kranzler, View ORCID ProfileJoel Gelernter
doi: https://doi.org/10.1101/738088
Hang Zhou
1Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
2Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA
Julia M. Sealock
3Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA
4Division of Medical Genetics, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Sandra Sanchez-Roige
5Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
Toni-Kim Clarke
6Division of Psychiatry, University of Edinburgh, Edinburgh, UK
Daniel Levey
1Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
2Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA
Zhongshan Cheng
1Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
2Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA
Boyang Li
7Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA
Renato Polimanti
1Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
2Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA
Rachel L. Kember
8Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
9Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA
Rachel Vickers Smith
10University of Louisville School of Nursing, Louisville, KY, USA
Johan H. Thygesen
11Division of Psychiatry, University College London, London, UK
Marsha Y. Morgan
12UCL Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, UK
Stephen R. Atkinson
13Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK
Mark R. Thursz
13Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK
Mette Nyegaard
14Department of Biomedicine, Aarhus University, Aarhus, Denmark
15Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark
16The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark
17Center for Genomics and Personalized Medicine, Aarhus, Denmark
Manuel Mattheisen
14Department of Biomedicine, Aarhus University, Aarhus, Denmark
18Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany
19Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Anders D. Børglum
14Department of Biomedicine, Aarhus University, Aarhus, Denmark
15Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark
16The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark
17Center for Genomics and Personalized Medicine, Aarhus, Denmark
Emma C. Johnson
20Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
Amy C. Justice
2Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA
21Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA
22Center for Interdisciplinary Research on AIDS, Yale School of Public Health, New Haven, CT, USA
Abraham A. Palmer
5Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
23Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA
Andrew McQuillin
11Division of Psychiatry, University College London, London, UK
Lea K. Davis
3Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA
4Division of Medical Genetics, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
24Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
Howard J. Edenberg
25Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
26Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
Arpana Agrawal
20Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
Henry R. Kranzler
9Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA
27Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Joel Gelernter
1Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
2Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA
28Departments of Genetics and Neuroscience, Yale University School of Medicine
Posted August 16, 2019.
Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality
Hang Zhou, Julia M. Sealock, Sandra Sanchez-Roige, Toni-Kim Clarke, Daniel Levey, Zhongshan Cheng, Boyang Li, Renato Polimanti, Rachel L. Kember, Rachel Vickers Smith, Johan H. Thygesen, Marsha Y. Morgan, Stephen R. Atkinson, Mark R. Thursz, Mette Nyegaard, Manuel Mattheisen, Anders D. Børglum, Emma C. Johnson, the VA Million Veteran Program, Amy C. Justice, Abraham A. Palmer, Andrew McQuillin, Lea K. Davis, Howard J. Edenberg, Arpana Agrawal, Henry R. Kranzler, Joel Gelernter
bioRxiv 738088; doi: https://doi.org/10.1101/738088
Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality
Hang Zhou, Julia M. Sealock, Sandra Sanchez-Roige, Toni-Kim Clarke, Daniel Levey, Zhongshan Cheng, Boyang Li, Renato Polimanti, Rachel L. Kember, Rachel Vickers Smith, Johan H. Thygesen, Marsha Y. Morgan, Stephen R. Atkinson, Mark R. Thursz, Mette Nyegaard, Manuel Mattheisen, Anders D. Børglum, Emma C. Johnson, the VA Million Veteran Program, Amy C. Justice, Abraham A. Palmer, Andrew McQuillin, Lea K. Davis, Howard J. Edenberg, Arpana Agrawal, Henry R. Kranzler, Joel Gelernter
bioRxiv 738088; doi: https://doi.org/10.1101/738088
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