New Results
Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group
View ORCID ProfileLauren E. Salminen, Philipp G. Sämann, Yuanchao Zheng, Emily L. Dennis, Emily K. Clarke-Rubright, Neda Jahanshad, Juan E. Iglesias, Christopher D. Whelan, Steven E. Bruce, Jasmeet P. Hayes, Soraya Seedat, Christopher L. Averill, Lee A. Baugh, Jessica Bomyea, Joanna Bright, Chanellé J. Buckle, Kyle Choi, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Stefan du Plessis, Jeremy A. Elman, Negar Fani, Gina L. Forster, Carol E. Franz, Jessie L. Frijling, Atilla Gonenc, Staci A. Gruber, Daniel W. Grupe, Jeffrey P. Guenette, Courtney C. Haswell, David Hofmann, Michael Hollifield, Babok Hosseini, Anna R. Hudson, Jonathan Ipser, Tanja Jovanovic, Amy Kennedy-Krage, Mitzy Kennis, Anthony King, Philipp Kinzel, Saskia B. J. Koch, Inga Koerte, Sheri M. Koopowitz, Mayuresh S. Korgaonkar, William S. Kremen, John Krystal, Lauren A. M. Lebois, Ifat Levy, Michael J. Lyons, Vincent A. Magnotta, Antje Manthey, Soichiro Nakahara, Laura Nawijn, Richard W. J. Neufeld, Jack B. Nitschke, Daniel C. M. O’Doherty, Robert H. Paul, Matthew Peverill, Faisal M. Rashid, Kerry J. Ressler, Annerine Roos, Christian Schmahl, Margaret A. Sheridan, Anika Sierk, Alan N. Simmons, Jeffrey S. Simons, Raluca M. Simons, Murray B. Stein, Jennifer S. Stevens, Benjamin Suarez-Jimenez, Jean Théberge, Kathleen Thomaes, Sophia I. Thomopoulos, Leigh L. van den Heuvel, Steven J. A. van der Werff, Theo G. M. van Erp, Sanne J. H. van Rooij, Mirjam van Zuiden, Tim Varkevisser, Robert R. J. M. Vermeiren, Tor D. Wager, Henrik Walter, Xin Wang, Sherry Winternitz, Jonathan D. Wolff, Kristen Wrocklage, Xi Zhu, Christopher R. K. Ching, Tiril P. Gurholt, Unn K. Haukvik, Ingrid Agartz, Chadi G. Abdallah, Richard Bryant, Judith K. Daniels, Michael DeBellis, Kelene A. Fercho, Elbert Geuze, Ilan Harpaz-Rotem, Julia I. Herzog, Milissa L. Kaufman, Jim Lagopoulos, Ruth A. Lanius, Katie A. McLaughlin, Sven C. Mueller, Yuval Neria, Miranda Olff, K. Luan Phan, Martha E. Shenton, Scott R. Sponheim, Dan J. Stein, Thomas Straube, Nic J. A. van der Wee, Dick J. Veltman, Paul M. Thompson, Rajendra A. Morey, Mark W. Logue, for the ENIGMA-PGC-PTSD Working Group
doi: https://doi.org/10.1101/739094
Lauren E. Salminen
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
Philipp G. Sämann
Max Planck Institute of Psychiatry, Munich, Germany
Yuanchao Zheng
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Emily L. Dennis
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USAPsychiatry Neuroimaging Laboratory, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USAStanford Neurodevelopment, Affect, and Psychopathology Laboratory, Stanford, CA, USADepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA
Emily K. Clarke-Rubright
Brain Imaging and Analysis Center, Duke University, Durham, NC, USAVISN 6 MIRECC, Durham VA, Durham, NC, USA
Neda Jahanshad
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
Juan E. Iglesias
Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UKMartinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USAComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
Christopher D. Whelan
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, IrelandResearch and Early Development, Biogen Inc., Cambridge, MA, USA
Steven E. Bruce
Department of Psychological Sciences, Center for Trauma Recovery, University of Missouri St. Louis, St. Louis, MO, USA
Jasmeet P. Hayes
Department of Psychology, The Ohio State University, Columbus, OH, USA
Soraya Seedat
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
Christopher L. Averill
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USA
Lee A. Baugh
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USACenter for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USASioux Falls VA Health Care System, Sioux Falls, SD, USA
Jessica Bomyea
VA San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USADepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA
Joanna Bright
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
Chanellé J. Buckle
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
Kyle Choi
University of California, San Diego, La Jolla, CA, USAHealth Services Research Center
Nicholas D. Davenport
Minneapolis VA Health Care System, Minneapolis, MN, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA
Richard J. Davidson
Center for Healthy Minds, University of Wisconsin-Madison, WI, USADepartment of Psychology, University of Wisconsin-Madison, Madison, WI, USADepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA
Maria Densmore
Department of Psychiatry, University of Western Ontario, London, ON, CanadaImaging Division, Lawson Health Research Institute, London, ON, Canada
Seth G. Disner
Minneapolis VA Health Care System, Minneapolis, MN, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA
Stefan du Plessis
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
Jeremy A. Elman
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USACenter for Behavior Genetics of Aging, San Diego, CA, USA
Negar Fani
Department of Psychiatry and Behavioral Science, Emory University, Atlanta, GA, USA
Gina L. Forster
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USACenter for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USABrain Health Research Centre, Department of Anatomy, University of Otago, Dunedin, New Zealand
Carol E. Franz
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USACenter for Behavior Genetics of Aging, San Diego, CA, USA
Jessie L. Frijling
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Atilla Gonenc
Cognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, MA, USADepartment of Psychiatry, Harvard Medical School, Boston, MA, USAMarijuana Investigations for Neuroscientific Discovery (MIND), McLean Hospital, Belmont, MA, USA
Staci A. Gruber
Cognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, MA, USADepartment of Psychiatry, Harvard Medical School, Boston, MA, USAMarijuana Investigations for Neuroscientific Discovery (MIND), McLean Hospital, Belmont, MA, USA
Daniel W. Grupe
Center for Healthy Minds, University of Wisconsin-Madison, WI, USA
Jeffrey P. Guenette
Division of Neuroradiology, Brigham and Women’s Hospital, Boston, MA, USA
Courtney C. Haswell
Brain Imaging and Analysis Center, Duke University, Durham, NC, USAVISN 6 MIRECC, Durham VA, Durham, NC, USA
David Hofmann
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany
Michael Hollifield
Program for Traumatic Stress, Tibor Rubin VA Medical Center, Long Beach, CA, USA
Babok Hosseini
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
Anna R. Hudson
Department of Experimental Clinical and Health Psychology, Ghent University, Belgium
Jonathan Ipser
Department of Psychiatry, University of Cape Town, Cape Town, South Africa
Tanja Jovanovic
Department of Psychiatry, Wayne State University, Detroit, MI, USA
Amy Kennedy-Krage
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
Mitzy Kennis
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The NetherlandsBrain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands
Anthony King
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
Philipp Kinzel
Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany
Saskia B. J. Koch
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The NetherlandsDonders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
Inga Koerte
Psychiatry Neuroimaging Laboratory, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA
Sheri M. Koopowitz
Department of Psychiatry, University of Cape Town, Cape Town, South Africa
Mayuresh S. Korgaonkar
Brain Dynamics Centre, Westmead Institute of Medical Research, University of Sydney, Westmead, NSW, Australia
William S. Kremen
VA San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USADepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USACenter for Behavior Genetics of Aging, San Diego, CA, USA
John Krystal
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USADepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Lauren A. M. Lebois
Department of Psychiatry, Harvard Medical School, Boston, MA, USADivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA
Ifat Levy
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USADepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA
Michael J. Lyons
Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA
Vincent A. Magnotta
Departments of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, IA, USA
Antje Manthey
University Medical Centre Charite, Berlin, Germany
Soichiro Nakahara
Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USAUnit 2, Candidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc, 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan
Laura Nawijn
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Psychiatry, Amsterdam University Medical Centers, Location VU University Medical Center, VU University, Amsterdam, The Netherlands
Richard W. J. Neufeld
Department of Psychiatry, University of Western Ontario, London, ON, CanadaDepartment of Psychology, University of Western Ontario, London, ON, Canada
Jack B. Nitschke
Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA
Daniel C. M. O’Doherty
University of the Sunshine Coast, Birtinya, QLD, Australia
Robert H. Paul
Missouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis MO, USA
Matthew Peverill
Department of Psychology, University of Washington, Seattle, WA, USA
Faisal M. Rashid
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
Kerry J. Ressler
Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USADepartment of Psychiatry, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA
Annerine Roos
SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa
Christian Schmahl
Department of Psychiatry, University of Western Ontario, London, ON, CanadaDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Margaret A. Sheridan
Department of Psychology and Brain Sciences, University of North Carolina at Chapel Hill, NC, USA
Anika Sierk
University Medical Centre Charite, Berlin, Germany
Alan N. Simmons
VA San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USADepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA
Jeffrey S. Simons
Sioux Falls VA Health Care System, Sioux Falls, SD, USADepartment of Psychology, University of South Dakota, Vermillion, SD, USA
Raluca M. Simons
Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USADepartment of Psychology, University of South Dakota, Vermillion, SD, USA
Murray B. Stein
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USADepartment of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA
Jennifer S. Stevens
Department of Psychiatry and Behavioral Science, Emory University, Atlanta, GA, USA
Benjamin Suarez-Jimenez
Department of Psychiatry, Columbia University Medical Center, New York, NY, USANew York State Psychiatric Institute, New York, NY, USA
Jean Théberge
Department of Psychiatry, University of Western Ontario, London, ON, CanadaImaging Division, Lawson Health Research Institute, London, ON, CanadaDepartment of Medical Biophysics, University of Western Ontario, London, ON, Canada
Kathleen Thomaes
GGZinGeest & VU Medical Center, Amsterdam, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands
Sophia I. Thomopoulos
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
Leigh L. van den Heuvel
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
Steven J. A. van der Werff
Psychiatry, LUMC, Leiden, The NetherlandsLeiden Institute for Brain and Cognition, Leiden, The Netherlands
Theo G. M. van Erp
Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USACenter for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA, USA
Sanne J. H. van Rooij
Department of Psychiatry and Behavioral Science, Emory University, Atlanta, GA, USA
Mirjam van Zuiden
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Tim Varkevisser
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The NetherlandsBrain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands
Robert R. J. M. Vermeiren
Child and Adolescent Psychiatry, LUMC, Leiden, The NetherlandsYouz - Parnassia Group
Tor D. Wager
Dartmouth College, Hanover, NH, USA
Henrik Walter
University Medical Centre Charite, Berlin, Germany
Xin Wang
Department of Psychiatry, University of Toledo, OH, USA
Sherry Winternitz
Department of Psychiatry, Harvard Medical School, Boston, MA, USADivision of Women’s Mental Health, McLean Hospital, Belmont, MA, USA
Jonathan D. Wolff
Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA
Kristen Wrocklage
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USADepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Xi Zhu
Department of Psychiatry, Columbia University Medical Center, New York, NY, USANew York State Psychiatric Institute, New York, NY, USA
Christopher R. K. Ching
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
Tiril P. Gurholt
Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NorwayNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Unn K. Haukvik
Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NorwayDepartment of Adult Psychiatry, University of Oslo, Norway
Ingrid Agartz
Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway
Chadi G. Abdallah
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USADepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Richard Bryant
School of Psychology, University of New South Wales, Sydney, NSW, Australia
Judith K. Daniels
Department of Clinical Psychology, University of Groningen, Groningen, The Netherlands
Michael DeBellis
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Kelene A. Fercho
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USACenter for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USASioux Falls VA Health Care System, Sioux Falls, SD, USA
Elbert Geuze
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The NetherlandsBrain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands
Ilan Harpaz-Rotem
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USADepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Julia I. Herzog
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Milissa L. Kaufman
Department of Psychiatry, Harvard Medical School, Boston, MA, USADivision of Women’s Mental Health, McLean Hospital, Belmont, MA, USA
Jim Lagopoulos
University of the Sunshine Coast, Birtinya, QLD, Australia
Ruth A. Lanius
Department of Psychiatry, University of Western Ontario, London, ON, CanadaImaging Division, Lawson Health Research Institute, London, ON, CanadaDepartment of Neuroscience, University of Western University, London, ON, Canada
Katie A. McLaughlin
Department of Psychology, Harvard University, Cambridge, MA, USA
Sven C. Mueller
Department of Experimental Clinical and Health Psychology, Ghent University, Belgium
Yuval Neria
Department of Psychiatry, Columbia University Medical Center, New York, NY, USANew York State Psychiatric Institute, New York, NY, USA
Miranda Olff
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The NetherlandsArq Psychotrauma Expert Group, Diemen, The Netherlands
K. Luan Phan
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USAMental Health Service Line, Jesse Brown VA Medical Center, Chicago, IL, USA
Martha E. Shenton
Psychiatry Neuroimaging Laboratory, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA
Scott R. Sponheim
Minneapolis VA Health Care System, Minneapolis, MN, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA
Dan J. Stein
SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa
Thomas Straube
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany
Nic J. A. van der Wee
Psychiatry, LUMC, Leiden, The NetherlandsLeiden Institute for Brain and Cognition, Leiden, The Netherlands
Dick J. Veltman
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Paul M. Thompson
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
Rajendra A. Morey
Brain Imaging and Analysis Center, Duke University, Durham, NC, USAVISN 6 MIRECC, Durham VA, Durham, NC, USA
Mark W. Logue
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USANational Center for PTSD Behavioral Sciences Division at VA Boston Healthcare System, Boston, MA, USADepartment of Psychiatry, Boston University School of Medicine, Boston, MA, USA
Abstract
Background PTSD and depression commonly co-occur and have been associated with smaller hippocampal volumes compared to healthy and trauma-exposed controls. However, the hippocampus is heterogeneous, with subregions that may be uniquely affected in individuals with PTSD and depression.
Methods We used random effects regressions and a harmonized neuroimaging protocol based on FreeSurfer (v6.0) to identify sub-structural hippocampal markers of current PTSD (C-PTSD), depression, and the interaction of these conditions across 31 cohorts worldwide (N=3,115; Mage=38.9±13.9 years). Secondary analyses tested these associations by sex and after modeling the simultaneous effects of remitted PTSD, childhood trauma, mild traumatic brain injury, and alcohol use disorder.
Results A significant negative main effect of depression (n=800, vs. no depression, n=1456) was observed in the hippocampal tail (ß=−0.13) and CA1 (ß=−0.09) after adjusting for covariates and multiple testing (adjusted p’s (q)=0.028). A main effect of C-PTSD (n=1042 vs. control, n=1359) was not significant, but an interaction between C-PTSD and depression was significant in the CA1 (ß=−0.24, q=0.044). Pairwise comparisons revealed significantly smaller CA1 volumes in individuals with C-PTSD+Depression than controls (ß=−0.12, q=0.012), C-PTSD-only (ß=−0.17, q=0.001), and Depression-only (ß=−0.18, q=0.023). Follow-up analyses revealed sex effects in the hippocampal tail of depressed females, and an interaction effect of C-PTSD and depression in the fimbria of males.
Conclusions Collectively our results suggest that depression is a stronger predictor of hippocampal volumetry than PTSD, particularly in the CA1, and provide compelling evidence of more pronounced hippocampal phenotypes in comorbid PTSD and depression compared to either condition alone.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Posted August 21, 2019.
Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group
Lauren E. Salminen, Philipp G. Sämann, Yuanchao Zheng, Emily L. Dennis, Emily K. Clarke-Rubright, Neda Jahanshad, Juan E. Iglesias, Christopher D. Whelan, Steven E. Bruce, Jasmeet P. Hayes, Soraya Seedat, Christopher L. Averill, Lee A. Baugh, Jessica Bomyea, Joanna Bright, Chanellé J. Buckle, Kyle Choi, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Stefan du Plessis, Jeremy A. Elman, Negar Fani, Gina L. Forster, Carol E. Franz, Jessie L. Frijling, Atilla Gonenc, Staci A. Gruber, Daniel W. Grupe, Jeffrey P. Guenette, Courtney C. Haswell, David Hofmann, Michael Hollifield, Babok Hosseini, Anna R. Hudson, Jonathan Ipser, Tanja Jovanovic, Amy Kennedy-Krage, Mitzy Kennis, Anthony King, Philipp Kinzel, Saskia B. J. Koch, Inga Koerte, Sheri M. Koopowitz, Mayuresh S. Korgaonkar, William S. Kremen, John Krystal, Lauren A. M. Lebois, Ifat Levy, Michael J. Lyons, Vincent A. Magnotta, Antje Manthey, Soichiro Nakahara, Laura Nawijn, Richard W. J. Neufeld, Jack B. Nitschke, Daniel C. M. O’Doherty, Robert H. Paul, Matthew Peverill, Faisal M. Rashid, Kerry J. Ressler, Annerine Roos, Christian Schmahl, Margaret A. Sheridan, Anika Sierk, Alan N. Simmons, Jeffrey S. Simons, Raluca M. Simons, Murray B. Stein, Jennifer S. Stevens, Benjamin Suarez-Jimenez, Jean Théberge, Kathleen Thomaes, Sophia I. Thomopoulos, Leigh L. van den Heuvel, Steven J. A. van der Werff, Theo G. M. van Erp, Sanne J. H. van Rooij, Mirjam van Zuiden, Tim Varkevisser, Robert R. J. M. Vermeiren, Tor D. Wager, Henrik Walter, Xin Wang, Sherry Winternitz, Jonathan D. Wolff, Kristen Wrocklage, Xi Zhu, Christopher R. K. Ching, Tiril P. Gurholt, Unn K. Haukvik, Ingrid Agartz, Chadi G. Abdallah, Richard Bryant, Judith K. Daniels, Michael DeBellis, Kelene A. Fercho, Elbert Geuze, Ilan Harpaz-Rotem, Julia I. Herzog, Milissa L. Kaufman, Jim Lagopoulos, Ruth A. Lanius, Katie A. McLaughlin, Sven C. Mueller, Yuval Neria, Miranda Olff, K. Luan Phan, Martha E. Shenton, Scott R. Sponheim, Dan J. Stein, Thomas Straube, Nic J. A. van der Wee, Dick J. Veltman, Paul M. Thompson, Rajendra A. Morey, Mark W. Logue, for the ENIGMA-PGC-PTSD Working Group
bioRxiv 739094; doi: https://doi.org/10.1101/739094
Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group
Lauren E. Salminen, Philipp G. Sämann, Yuanchao Zheng, Emily L. Dennis, Emily K. Clarke-Rubright, Neda Jahanshad, Juan E. Iglesias, Christopher D. Whelan, Steven E. Bruce, Jasmeet P. Hayes, Soraya Seedat, Christopher L. Averill, Lee A. Baugh, Jessica Bomyea, Joanna Bright, Chanellé J. Buckle, Kyle Choi, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Stefan du Plessis, Jeremy A. Elman, Negar Fani, Gina L. Forster, Carol E. Franz, Jessie L. Frijling, Atilla Gonenc, Staci A. Gruber, Daniel W. Grupe, Jeffrey P. Guenette, Courtney C. Haswell, David Hofmann, Michael Hollifield, Babok Hosseini, Anna R. Hudson, Jonathan Ipser, Tanja Jovanovic, Amy Kennedy-Krage, Mitzy Kennis, Anthony King, Philipp Kinzel, Saskia B. J. Koch, Inga Koerte, Sheri M. Koopowitz, Mayuresh S. Korgaonkar, William S. Kremen, John Krystal, Lauren A. M. Lebois, Ifat Levy, Michael J. Lyons, Vincent A. Magnotta, Antje Manthey, Soichiro Nakahara, Laura Nawijn, Richard W. J. Neufeld, Jack B. Nitschke, Daniel C. M. O’Doherty, Robert H. Paul, Matthew Peverill, Faisal M. Rashid, Kerry J. Ressler, Annerine Roos, Christian Schmahl, Margaret A. Sheridan, Anika Sierk, Alan N. Simmons, Jeffrey S. Simons, Raluca M. Simons, Murray B. Stein, Jennifer S. Stevens, Benjamin Suarez-Jimenez, Jean Théberge, Kathleen Thomaes, Sophia I. Thomopoulos, Leigh L. van den Heuvel, Steven J. A. van der Werff, Theo G. M. van Erp, Sanne J. H. van Rooij, Mirjam van Zuiden, Tim Varkevisser, Robert R. J. M. Vermeiren, Tor D. Wager, Henrik Walter, Xin Wang, Sherry Winternitz, Jonathan D. Wolff, Kristen Wrocklage, Xi Zhu, Christopher R. K. Ching, Tiril P. Gurholt, Unn K. Haukvik, Ingrid Agartz, Chadi G. Abdallah, Richard Bryant, Judith K. Daniels, Michael DeBellis, Kelene A. Fercho, Elbert Geuze, Ilan Harpaz-Rotem, Julia I. Herzog, Milissa L. Kaufman, Jim Lagopoulos, Ruth A. Lanius, Katie A. McLaughlin, Sven C. Mueller, Yuval Neria, Miranda Olff, K. Luan Phan, Martha E. Shenton, Scott R. Sponheim, Dan J. Stein, Thomas Straube, Nic J. A. van der Wee, Dick J. Veltman, Paul M. Thompson, Rajendra A. Morey, Mark W. Logue, for the ENIGMA-PGC-PTSD Working Group
bioRxiv 739094; doi: https://doi.org/10.1101/739094
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