Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group

View ORCID ProfileLauren E. Salminen, Philipp G. Sämann, Yuanchao Zheng, Emily L. Dennis, Emily K. Clarke-Rubright, Neda Jahanshad, Juan E. Iglesias, Christopher D. Whelan, Steven E. Bruce, Jasmeet P. Hayes, Soraya Seedat, Christopher L. Averill, Lee A. Baugh, Jessica Bomyea, Joanna Bright, Chanellé J. Buckle, Kyle Choi, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Stefan du Plessis, Jeremy A. Elman, Negar Fani, Gina L. Forster, Carol E. Franz, Jessie L. Frijling, Atilla Gonenc, Staci A. Gruber, Daniel W. Grupe, Jeffrey P. Guenette, Courtney C. Haswell, David Hofmann, Michael Hollifield, Babok Hosseini, Anna R. Hudson, Jonathan Ipser, Tanja Jovanovic, Amy Kennedy-Krage, Mitzy Kennis, Anthony King, Philipp Kinzel, Saskia B. J. Koch, Inga Koerte, Sheri M. Koopowitz, Mayuresh S. Korgaonkar, William S. Kremen, John Krystal, Lauren A. M. Lebois, Ifat Levy, Michael J. Lyons, Vincent A. Magnotta, Antje Manthey, Soichiro Nakahara, Laura Nawijn, Richard W. J. Neufeld, Jack B. Nitschke, Daniel C. M. O’Doherty, Robert H. Paul, Matthew Peverill, Faisal M. Rashid, Kerry J. Ressler, Annerine Roos, Christian Schmahl, Margaret A. Sheridan, Anika Sierk, Alan N. Simmons, Jeffrey S. Simons, Raluca M. Simons, Murray B. Stein, Jennifer S. Stevens, Benjamin Suarez-Jimenez, Jean Théberge, Kathleen Thomaes, Sophia I. Thomopoulos, Leigh L. van den Heuvel, Steven J. A. van der Werff, Theo G. M. van Erp, Sanne J. H. van Rooij, Mirjam van Zuiden, Tim Varkevisser, Robert R. J. M. Vermeiren, Tor D. Wager, Henrik Walter, Xin Wang, Sherry Winternitz, Jonathan D. Wolff, Kristen Wrocklage, Xi Zhu, Christopher R. K. Ching, Tiril P. Gurholt, Unn K. Haukvik, Ingrid Agartz, Chadi G. Abdallah, Richard Bryant, Judith K. Daniels, Michael DeBellis, Kelene A. Fercho, Elbert Geuze, Ilan Harpaz-Rotem, Julia I. Herzog, Milissa L. Kaufman, Jim Lagopoulos, Ruth A. Lanius, Katie A. McLaughlin, Sven C. Mueller, Yuval Neria, Miranda Olff, K. Luan Phan, Martha E. Shenton, Scott R. Sponheim, Dan J. Stein, Thomas Straube, Nic J. A. van der Wee, Dick J. Veltman, Paul M. Thompson, Rajendra A. Morey, Mark W. Logue, for the ENIGMA-PGC-PTSD Working Group
doi: https://doi.org/10.1101/739094
Lauren E. Salminen
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Lauren E. Salminen
  • For correspondence: lauren.salminen@loni.usc.edu
Philipp G. Sämann
Max Planck Institute of Psychiatry, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuanchao Zheng
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emily L. Dennis
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USAPsychiatry Neuroimaging Laboratory, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USAStanford Neurodevelopment, Affect, and Psychopathology Laboratory, Stanford, CA, USADepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emily K. Clarke-Rubright
Brain Imaging and Analysis Center, Duke University, Durham, NC, USAVISN 6 MIRECC, Durham VA, Durham, NC, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Neda Jahanshad
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Juan E. Iglesias
Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UKMartinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USAComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher D. Whelan
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, IrelandResearch and Early Development, Biogen Inc., Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Steven E. Bruce
Department of Psychological Sciences, Center for Trauma Recovery, University of Missouri St. Louis, St. Louis, MO, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jasmeet P. Hayes
Department of Psychology, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Soraya Seedat
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher L. Averill
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lee A. Baugh
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USACenter for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USASioux Falls VA Health Care System, Sioux Falls, SD, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jessica Bomyea
VA San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USADepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joanna Bright
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chanellé J. Buckle
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kyle Choi
University of California, San Diego, La Jolla, CA, USAHealth Services Research Center
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nicholas D. Davenport
Minneapolis VA Health Care System, Minneapolis, MN, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richard J. Davidson
Center for Healthy Minds, University of Wisconsin-Madison, WI, USADepartment of Psychology, University of Wisconsin-Madison, Madison, WI, USADepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Densmore
Department of Psychiatry, University of Western Ontario, London, ON, CanadaImaging Division, Lawson Health Research Institute, London, ON, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Seth G. Disner
Minneapolis VA Health Care System, Minneapolis, MN, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stefan du Plessis
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeremy A. Elman
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USACenter for Behavior Genetics of Aging, San Diego, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Negar Fani
Department of Psychiatry and Behavioral Science, Emory University, Atlanta, GA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gina L. Forster
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USACenter for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USABrain Health Research Centre, Department of Anatomy, University of Otago, Dunedin, New Zealand
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carol E. Franz
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USACenter for Behavior Genetics of Aging, San Diego, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jessie L. Frijling
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Atilla Gonenc
Cognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, MA, USADepartment of Psychiatry, Harvard Medical School, Boston, MA, USAMarijuana Investigations for Neuroscientific Discovery (MIND), McLean Hospital, Belmont, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Staci A. Gruber
Cognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, MA, USADepartment of Psychiatry, Harvard Medical School, Boston, MA, USAMarijuana Investigations for Neuroscientific Discovery (MIND), McLean Hospital, Belmont, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel W. Grupe
Center for Healthy Minds, University of Wisconsin-Madison, WI, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeffrey P. Guenette
Division of Neuroradiology, Brigham and Women’s Hospital, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Courtney C. Haswell
Brain Imaging and Analysis Center, Duke University, Durham, NC, USAVISN 6 MIRECC, Durham VA, Durham, NC, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Hofmann
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Hollifield
Program for Traumatic Stress, Tibor Rubin VA Medical Center, Long Beach, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Babok Hosseini
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna R. Hudson
Department of Experimental Clinical and Health Psychology, Ghent University, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan Ipser
Department of Psychiatry, University of Cape Town, Cape Town, South Africa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tanja Jovanovic
Department of Psychiatry, Wayne State University, Detroit, MI, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amy Kennedy-Krage
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mitzy Kennis
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The NetherlandsBrain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anthony King
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Philipp Kinzel
Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Saskia B. J. Koch
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The NetherlandsDonders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Inga Koerte
Psychiatry Neuroimaging Laboratory, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sheri M. Koopowitz
Department of Psychiatry, University of Cape Town, Cape Town, South Africa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mayuresh S. Korgaonkar
Brain Dynamics Centre, Westmead Institute of Medical Research, University of Sydney, Westmead, NSW, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William S. Kremen
VA San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USADepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USACenter for Behavior Genetics of Aging, San Diego, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John Krystal
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USADepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lauren A. M. Lebois
Department of Psychiatry, Harvard Medical School, Boston, MA, USADivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ifat Levy
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USADepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael J. Lyons
Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vincent A. Magnotta
Departments of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, IA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antje Manthey
University Medical Centre Charite, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Soichiro Nakahara
Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USAUnit 2, Candidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc, 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura Nawijn
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Psychiatry, Amsterdam University Medical Centers, Location VU University Medical Center, VU University, Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richard W. J. Neufeld
Department of Psychiatry, University of Western Ontario, London, ON, CanadaDepartment of Psychology, University of Western Ontario, London, ON, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jack B. Nitschke
Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel C. M. O’Doherty
University of the Sunshine Coast, Birtinya, QLD, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert H. Paul
Missouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis MO, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthew Peverill
Department of Psychology, University of Washington, Seattle, WA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Faisal M. Rashid
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kerry J. Ressler
Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USADepartment of Psychiatry, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Annerine Roos
SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Schmahl
Department of Psychiatry, University of Western Ontario, London, ON, CanadaDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Margaret A. Sheridan
Department of Psychology and Brain Sciences, University of North Carolina at Chapel Hill, NC, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anika Sierk
University Medical Centre Charite, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alan N. Simmons
VA San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USADepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeffrey S. Simons
Sioux Falls VA Health Care System, Sioux Falls, SD, USADepartment of Psychology, University of South Dakota, Vermillion, SD, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raluca M. Simons
Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USADepartment of Psychology, University of South Dakota, Vermillion, SD, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Murray B. Stein
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USADepartment of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jennifer S. Stevens
Department of Psychiatry and Behavioral Science, Emory University, Atlanta, GA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benjamin Suarez-Jimenez
Department of Psychiatry, Columbia University Medical Center, New York, NY, USANew York State Psychiatric Institute, New York, NY, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean Théberge
Department of Psychiatry, University of Western Ontario, London, ON, CanadaImaging Division, Lawson Health Research Institute, London, ON, CanadaDepartment of Medical Biophysics, University of Western Ontario, London, ON, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kathleen Thomaes
GGZinGeest & VU Medical Center, Amsterdam, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sophia I. Thomopoulos
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leigh L. van den Heuvel
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Steven J. A. van der Werff
Psychiatry, LUMC, Leiden, The NetherlandsLeiden Institute for Brain and Cognition, Leiden, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Theo G. M. van Erp
Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USACenter for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sanne J. H. van Rooij
Department of Psychiatry and Behavioral Science, Emory University, Atlanta, GA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mirjam van Zuiden
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tim Varkevisser
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The NetherlandsBrain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert R. J. M. Vermeiren
Child and Adolescent Psychiatry, LUMC, Leiden, The NetherlandsYouz - Parnassia Group
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tor D. Wager
Dartmouth College, Hanover, NH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Henrik Walter
University Medical Centre Charite, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xin Wang
Department of Psychiatry, University of Toledo, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sherry Winternitz
Department of Psychiatry, Harvard Medical School, Boston, MA, USADivision of Women’s Mental Health, McLean Hospital, Belmont, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan D. Wolff
Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kristen Wrocklage
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USADepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xi Zhu
Department of Psychiatry, Columbia University Medical Center, New York, NY, USANew York State Psychiatric Institute, New York, NY, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher R. K. Ching
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tiril P. Gurholt
Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NorwayNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Unn K. Haukvik
Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NorwayDepartment of Adult Psychiatry, University of Oslo, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ingrid Agartz
Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chadi G. Abdallah
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USADepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richard Bryant
School of Psychology, University of New South Wales, Sydney, NSW, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Judith K. Daniels
Department of Clinical Psychology, University of Groningen, Groningen, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael DeBellis
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kelene A. Fercho
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USACenter for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USASioux Falls VA Health Care System, Sioux Falls, SD, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elbert Geuze
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The NetherlandsBrain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ilan Harpaz-Rotem
Clinical Neuroscience Division, National Center for PTSD, West Haven, CT, USADepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julia I. Herzog
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Milissa L. Kaufman
Department of Psychiatry, Harvard Medical School, Boston, MA, USADivision of Women’s Mental Health, McLean Hospital, Belmont, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jim Lagopoulos
University of the Sunshine Coast, Birtinya, QLD, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ruth A. Lanius
Department of Psychiatry, University of Western Ontario, London, ON, CanadaImaging Division, Lawson Health Research Institute, London, ON, CanadaDepartment of Neuroscience, University of Western University, London, ON, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katie A. McLaughlin
Department of Psychology, Harvard University, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sven C. Mueller
Department of Experimental Clinical and Health Psychology, Ghent University, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuval Neria
Department of Psychiatry, Columbia University Medical Center, New York, NY, USANew York State Psychiatric Institute, New York, NY, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Miranda Olff
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The NetherlandsArq Psychotrauma Expert Group, Diemen, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. Luan Phan
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USAMental Health Service Line, Jesse Brown VA Medical Center, Chicago, IL, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martha E. Shenton
Psychiatry Neuroimaging Laboratory, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Scott R. Sponheim
Minneapolis VA Health Care System, Minneapolis, MN, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dan J. Stein
SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Straube
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nic J. A. van der Wee
Psychiatry, LUMC, Leiden, The NetherlandsLeiden Institute for Brain and Cognition, Leiden, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dick J. Veltman
Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul M. Thompson
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rajendra A. Morey
Brain Imaging and Analysis Center, Duke University, Durham, NC, USAVISN 6 MIRECC, Durham VA, Durham, NC, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark W. Logue
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USANational Center for PTSD Behavioral Sciences Division at VA Boston Healthcare System, Boston, MA, USADepartment of Psychiatry, Boston University School of Medicine, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Background PTSD and depression commonly co-occur and have been associated with smaller hippocampal volumes compared to healthy and trauma-exposed controls. However, the hippocampus is heterogeneous, with subregions that may be uniquely affected in individuals with PTSD and depression.

Methods We used random effects regressions and a harmonized neuroimaging protocol based on FreeSurfer (v6.0) to identify sub-structural hippocampal markers of current PTSD (C-PTSD), depression, and the interaction of these conditions across 31 cohorts worldwide (N=3,115; Mage=38.9±13.9 years). Secondary analyses tested these associations by sex and after modeling the simultaneous effects of remitted PTSD, childhood trauma, mild traumatic brain injury, and alcohol use disorder.

Results A significant negative main effect of depression (n=800, vs. no depression, n=1456) was observed in the hippocampal tail (ß=−0.13) and CA1 (ß=−0.09) after adjusting for covariates and multiple testing (adjusted p’s (q)=0.028). A main effect of C-PTSD (n=1042 vs. control, n=1359) was not significant, but an interaction between C-PTSD and depression was significant in the CA1 (ß=−0.24, q=0.044). Pairwise comparisons revealed significantly smaller CA1 volumes in individuals with C-PTSD+Depression than controls (ß=−0.12, q=0.012), C-PTSD-only (ß=−0.17, q=0.001), and Depression-only (ß=−0.18, q=0.023). Follow-up analyses revealed sex effects in the hippocampal tail of depressed females, and an interaction effect of C-PTSD and depression in the fimbria of males.

Conclusions Collectively our results suggest that depression is a stronger predictor of hippocampal volumetry than PTSD, particularly in the CA1, and provide compelling evidence of more pronounced hippocampal phenotypes in comorbid PTSD and depression compared to either condition alone.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Back to top
PreviousNext
Posted August 21, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group
Lauren E. Salminen, Philipp G. Sämann, Yuanchao Zheng, Emily L. Dennis, Emily K. Clarke-Rubright, Neda Jahanshad, Juan E. Iglesias, Christopher D. Whelan, Steven E. Bruce, Jasmeet P. Hayes, Soraya Seedat, Christopher L. Averill, Lee A. Baugh, Jessica Bomyea, Joanna Bright, Chanellé J. Buckle, Kyle Choi, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Stefan du Plessis, Jeremy A. Elman, Negar Fani, Gina L. Forster, Carol E. Franz, Jessie L. Frijling, Atilla Gonenc, Staci A. Gruber, Daniel W. Grupe, Jeffrey P. Guenette, Courtney C. Haswell, David Hofmann, Michael Hollifield, Babok Hosseini, Anna R. Hudson, Jonathan Ipser, Tanja Jovanovic, Amy Kennedy-Krage, Mitzy Kennis, Anthony King, Philipp Kinzel, Saskia B. J. Koch, Inga Koerte, Sheri M. Koopowitz, Mayuresh S. Korgaonkar, William S. Kremen, John Krystal, Lauren A. M. Lebois, Ifat Levy, Michael J. Lyons, Vincent A. Magnotta, Antje Manthey, Soichiro Nakahara, Laura Nawijn, Richard W. J. Neufeld, Jack B. Nitschke, Daniel C. M. O’Doherty, Robert H. Paul, Matthew Peverill, Faisal M. Rashid, Kerry J. Ressler, Annerine Roos, Christian Schmahl, Margaret A. Sheridan, Anika Sierk, Alan N. Simmons, Jeffrey S. Simons, Raluca M. Simons, Murray B. Stein, Jennifer S. Stevens, Benjamin Suarez-Jimenez, Jean Théberge, Kathleen Thomaes, Sophia I. Thomopoulos, Leigh L. van den Heuvel, Steven J. A. van der Werff, Theo G. M. van Erp, Sanne J. H. van Rooij, Mirjam van Zuiden, Tim Varkevisser, Robert R. J. M. Vermeiren, Tor D. Wager, Henrik Walter, Xin Wang, Sherry Winternitz, Jonathan D. Wolff, Kristen Wrocklage, Xi Zhu, Christopher R. K. Ching, Tiril P. Gurholt, Unn K. Haukvik, Ingrid Agartz, Chadi G. Abdallah, Richard Bryant, Judith K. Daniels, Michael DeBellis, Kelene A. Fercho, Elbert Geuze, Ilan Harpaz-Rotem, Julia I. Herzog, Milissa L. Kaufman, Jim Lagopoulos, Ruth A. Lanius, Katie A. McLaughlin, Sven C. Mueller, Yuval Neria, Miranda Olff, K. Luan Phan, Martha E. Shenton, Scott R. Sponheim, Dan J. Stein, Thomas Straube, Nic J. A. van der Wee, Dick J. Veltman, Paul M. Thompson, Rajendra A. Morey, Mark W. Logue, for the ENIGMA-PGC-PTSD Working Group
bioRxiv 739094; doi: https://doi.org/10.1101/739094
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group
Lauren E. Salminen, Philipp G. Sämann, Yuanchao Zheng, Emily L. Dennis, Emily K. Clarke-Rubright, Neda Jahanshad, Juan E. Iglesias, Christopher D. Whelan, Steven E. Bruce, Jasmeet P. Hayes, Soraya Seedat, Christopher L. Averill, Lee A. Baugh, Jessica Bomyea, Joanna Bright, Chanellé J. Buckle, Kyle Choi, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Stefan du Plessis, Jeremy A. Elman, Negar Fani, Gina L. Forster, Carol E. Franz, Jessie L. Frijling, Atilla Gonenc, Staci A. Gruber, Daniel W. Grupe, Jeffrey P. Guenette, Courtney C. Haswell, David Hofmann, Michael Hollifield, Babok Hosseini, Anna R. Hudson, Jonathan Ipser, Tanja Jovanovic, Amy Kennedy-Krage, Mitzy Kennis, Anthony King, Philipp Kinzel, Saskia B. J. Koch, Inga Koerte, Sheri M. Koopowitz, Mayuresh S. Korgaonkar, William S. Kremen, John Krystal, Lauren A. M. Lebois, Ifat Levy, Michael J. Lyons, Vincent A. Magnotta, Antje Manthey, Soichiro Nakahara, Laura Nawijn, Richard W. J. Neufeld, Jack B. Nitschke, Daniel C. M. O’Doherty, Robert H. Paul, Matthew Peverill, Faisal M. Rashid, Kerry J. Ressler, Annerine Roos, Christian Schmahl, Margaret A. Sheridan, Anika Sierk, Alan N. Simmons, Jeffrey S. Simons, Raluca M. Simons, Murray B. Stein, Jennifer S. Stevens, Benjamin Suarez-Jimenez, Jean Théberge, Kathleen Thomaes, Sophia I. Thomopoulos, Leigh L. van den Heuvel, Steven J. A. van der Werff, Theo G. M. van Erp, Sanne J. H. van Rooij, Mirjam van Zuiden, Tim Varkevisser, Robert R. J. M. Vermeiren, Tor D. Wager, Henrik Walter, Xin Wang, Sherry Winternitz, Jonathan D. Wolff, Kristen Wrocklage, Xi Zhu, Christopher R. K. Ching, Tiril P. Gurholt, Unn K. Haukvik, Ingrid Agartz, Chadi G. Abdallah, Richard Bryant, Judith K. Daniels, Michael DeBellis, Kelene A. Fercho, Elbert Geuze, Ilan Harpaz-Rotem, Julia I. Herzog, Milissa L. Kaufman, Jim Lagopoulos, Ruth A. Lanius, Katie A. McLaughlin, Sven C. Mueller, Yuval Neria, Miranda Olff, K. Luan Phan, Martha E. Shenton, Scott R. Sponheim, Dan J. Stein, Thomas Straube, Nic J. A. van der Wee, Dick J. Veltman, Paul M. Thompson, Rajendra A. Morey, Mark W. Logue, for the ENIGMA-PGC-PTSD Working Group
bioRxiv 739094; doi: https://doi.org/10.1101/739094

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (1522)
  • Biochemistry (2475)
  • Bioengineering (1731)
  • Bioinformatics (9655)
  • Biophysics (3892)
  • Cancer Biology (2964)
  • Cell Biology (4185)
  • Clinical Trials (135)
  • Developmental Biology (2622)
  • Ecology (4092)
  • Epidemiology (2031)
  • Evolutionary Biology (6884)
  • Genetics (5202)
  • Genomics (6490)
  • Immunology (2181)
  • Microbiology (6928)
  • Molecular Biology (2750)
  • Neuroscience (17245)
  • Paleontology (126)
  • Pathology (425)
  • Pharmacology and Toxicology (705)
  • Physiology (1055)
  • Plant Biology (2484)
  • Scientific Communication and Education (642)
  • Synthetic Biology (828)
  • Systems Biology (2684)
  • Zoology (429)