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Modeling vaccine-induced immunotherapy: treatment scheduling and robustness with virtual mice cohorts

Priya Bhatt, Manoj Kambara, Shari Pilon-Thomas, Katarzyna A. Rejniak, Ibrahim M. Chamseddine
doi: https://doi.org/10.1101/740878
Priya Bhatt
1Ottawa Hills High School. Ottawa Hills, OH
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Manoj Kambara
2Land O’Lakes High School, Land O’Lakes, FL
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Shari Pilon-Thomas
4The Immunology Department; H. Lee Moffitt Cancer Center & Research Institute, Tampa FL 33612
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Katarzyna A. Rejniak
3The Integrated Mathematical Oncology Department
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Ibrahim M. Chamseddine
3The Integrated Mathematical Oncology Department
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  • For correspondence: ibrahim.chamseddine@moffitt.org
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Abstract

Therapeutic vaccines are used to boost patients’ immune system activity by imposing signals that increase T cell proliferation or infiltration. A large population of cytotoxic T cells may then be able to reduce tumor growth. We developed here a mathematical model of vaccine-induced immunotherapy and used it to test the vaccine frequency and doses that can reduce tumor burden. Since tumors are heterogeneous, we examined if the proposed treatments are robust; i.e, are successful for a wide range of tumors. This was assessed by constructing virtual mice cohorts. Together, the optimal and most robust treatment protocol was determined through mathematical modeling.

Footnotes

  • This research was supported by the Moffitt Center for Immunization and Infection Research in Cancer (CIIRC) Award. The work of PB and MK was supported in part by the Jacobson Foundation for the Moffitt High-School Internship Program in Integrated Mathematical Oncology (HIP-IMO) during the summer of 2019.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted August 21, 2019.
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Modeling vaccine-induced immunotherapy: treatment scheduling and robustness with virtual mice cohorts
Priya Bhatt, Manoj Kambara, Shari Pilon-Thomas, Katarzyna A. Rejniak, Ibrahim M. Chamseddine
bioRxiv 740878; doi: https://doi.org/10.1101/740878
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Modeling vaccine-induced immunotherapy: treatment scheduling and robustness with virtual mice cohorts
Priya Bhatt, Manoj Kambara, Shari Pilon-Thomas, Katarzyna A. Rejniak, Ibrahim M. Chamseddine
bioRxiv 740878; doi: https://doi.org/10.1101/740878

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