New Results
Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies
Melissa A. Munn-Chernoff, Emma C. Johnson, Yi-Ling Chou, View ORCID ProfileJonathan R.I. Coleman, Laura M. Thornton, Raymond K. Walters, Zeynep Yilmaz, Jessica H. Baker, Christopher Hübel, Scott Gordon, Sarah E. Medland, Hunna J. Watson, Héléna A. Gaspar, Julien Bryois, Anke Hinney, Virpi M. Leppä, Manuel Mattheisen, Stephan Ripke, View ORCID ProfileShuyang Yao, Paola Giusti-Rodríguez, Ken B. Hanscombe, Roger A.H. Adan, Lars Alfredsson, Tetsuya Ando, Ole A. Andreassen, Wade H. Berrettini, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Matteo Cassina, Sven Cichon, Maurizio Clementi, Roger D. Cone, Philippe Courtet, Scott Crow, James J. Crowley, Unna N. Danner, Oliver S.P. Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo, Laramie E. Duncan, Karin Egberts, Stefan Ehrlich, Geòrgia Escaramís, Tõnu Esko, Xavier Estivill, Anne Farmer, Angela Favaro, Fernando Fernández-Aranda, Manfred M. Fichter, Krista Fischer, Manuel Föcker, Lenka Foretova, Andreas J. Forstner, Monica Forzan, Christopher S. Franklin, Steven Gallinger, Ina Giegling, Johanna Giuranna, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Sébastien Guillaume, Yiran Guo, Hakon Hakonarson, Konstantinos Hatzikotoulas, Joanna Hauser, Johannes Hebebrand, Sietske G. Helder, Stefan Herms, Beate Herpertz-Dahlmann, Wolfgang Herzog, View ORCID ProfileLaura M. Huckins, James I. Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimir Janout, Susana Jiménez-Murcia, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Leila Karhunen, Andreas Karwautz, Martien J.H. Kas, James L. Kennedy, Anna Keski-Rahkonen, Kirsty Kiezebrink, Youl-Ri Kim, Kelly L. Klump, Gun Peggy S. Knudsen, Maria C. La Via, Stephanie Le Hellard, Robert D. Levitan, Dong Li, Lisa Lilenfeld, Bochao Danae Lin, Jolanta Lissowska, Jurjen Luykx, Pierre J. Magistretti, Mario Maj, Katrin Mannik, Sara Marsal, Christian R. Marshall, Morten Mattingsdal, Sara McDevitt, Peter McGuffin, Andres Metspalu, Ingrid Meulenbelt, Nadia Micali, Karen Mitchell, Alessio Maria Monteleone, Palmiero Monteleone, Benedetta Nacmias, Marie Navratilova, Ioanna Ntalla, Julie K. O’Toole, Roel A. Ophoff, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papezova, Dalila Pinto, Raquel Rabionet, Anu Raevuori, Nicolas Ramoz, Ted Reichborn-Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Alessandro Rotondo, Dan Rujescu, Filip Rybakowski, Paolo Santonastaso, André Scherag, Stephen W. Scherer, Ulrike Schmidt, Nicholas J. Schork, Alexandra Schosser, Jochen Seitz, Lenka Slachtova, P. Eline Slagboom, Margarita C.T. Slof-Op’t Landt, Agnieszka Slopien, Sandro Sorbi, Beata Świątkowska, Jin P. Szatkiewicz, Ioanna Tachmazidou, Elena Tenconi, Alfonso Tortorella, Federica Tozzi, Janet Treasure, Artemis Tsitsika, Marta Tyszkiewicz-Nwafor, Konstantinos Tziouvas, Annemarie A. van Elburg, Eric F. van Furth, Gudrun Wagner, Esther Walton, Elisabeth Widen, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Andrew W. Bergen, Joseph M. Boden, Harry Brandt, Steven Crawford, Katherine A. Halmi, L. John Horwood, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, James Mitchell, Catherine M. Olsen, John F. Pearson, Nancy L. Pedersen, Michael Strober, Thomas Werge, David C. Whiteman, D. Blake Woodside, Jakob Grove, Anjali K. Henders, Janne T. Larsen, Richard Parker, Liselotte V. Petersen, Jennifer Jordan, View ORCID ProfileMartin A. Kennedy, Andreas Birgegård, Paul Lichtenstein, Claes Norring, Mikael Landén, Preben Bo Mortensen, Renato Polimanti, Jeanette N. McClintick, Amy E. Adkins, Fazil Aliev, Silviu-Alin Bacanu, Anthony Batzler, Sarah Bertelsen, Joanna M. Biernacka, Tim B. Bigdeli, Li-Shiun Chen, Toni-Kim Clarke, Franziska Degenhardt, Anna R. Docherty, View ORCID ProfileAlexis C. Edwards, Jerome C. Foo, Louis Fox, Josef Frank, Laura M. Hack, Annette M. Hartmann, Sarah M. Hartz, Stefanie Heilmann-Heimbach, Colin Hodgkinson, Per Hoffmann, Jouke-Jan Hottenga, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Dongbing Lai, Lannie Ligthart, Anu Loukola, Brion S. Maher, Hamdi Mbarek, View ORCID ProfileAndrew M. McIntosh, Matthew B. McQueen, Jacquelyn L. Meyers, Yuri Milaneschi, Teemu Palviainen, Roseann E. Peterson, Euijung Ryu, Nancy L. Saccone, Jessica E. Salvatore, Sandra Sanchez-Roige, Melanie Schwandt, Richard Sherva, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley T. Webb, Robbee Wedow, Leah Wetherill, Amanda G. Wills, Hang Zhou, Jason D. Boardman, Danfeng Chen, Doo-Sup Choi, William E. Copeland, Robert C. Culverhouse, Norbert Dahmen, Louisa Degenhardt, Benjamin W. Domingue, Mark A. Frye, Wolfgang Gäbel, Caroline Hayward, Marcus Ising, Margaret Keyes, Falk Kiefer, Gabrielle Koller, John Kramer, Samuel Kuperman, Susanne Lucae, Michael T. Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Bertram Müller-Myhsok, Alison D. Murray, John I. Nurnberger, Ulrich Preuss, Katri Räikkönen, Maureen D. Reynolds, Monika Ridinger, Norbert Scherbaum, Marc A. Schuckit, Michael Soyka, Jens Treutlein, Stephanie H. Witt, Norbert Wodarz, Peter Zill, Daniel E. Adkins, Dorret I. Boomsma, Laura J. Bierut, Sandra A. Brown, Kathleen K. Bucholz, E. Jane Costello, Harriet de Wit, Nancy Diazgranados, Johan G. Eriksson, Lindsay A. Farrer, Tatiana M. Foroud, Nathan A. Gillespie, View ORCID ProfileAlison M. Goate, David Goldman, Richard A. Grucza, Dana B. Hancock, Kathleen Mullan Harris, Victor Hesselbrock, John K. Hewitt, Christian J. Hopfer, William G. Iacono, Eric O. Johnson, Victor M. Karpyak, Kenneth S. Kendler, Henry R. Kranzler, Kenneth Krauter, Penelope A. Lind, Matt McGue, James MacKillop, Pamela A.F. Madden, Hermine H. Maes, Patrik K.E. Magnusson, Elliot C. Nelson, Markus M. Nöthen, View ORCID ProfileAbraham A. Palmer, Brenda W.J.H. Penninx, Bernice Porjesz, John P. Rice, Marcella Rietschel, Brien P. Riley, Richard J. Rose, Pei-Hong Shen, Judy Silberg, Michael C. Stallings, Ralph E. Tarter, Michael M. Vanyukov, Scott Vrieze, Tamara L. Wall, John B. Whitfield, Hongyu Zhao, Benjamin M. Neale, Tracey D. Wade, Andrew C. Heath, Grant W. Montgomery, Nicholas G. Martin, Patrick F. Sullivan, Jaakko Kaprio, Gerome Breen, View ORCID ProfileJoel Gelernter, Howard J. Edenberg, Cynthia M. Bulik, Arpana Agrawal
doi: https://doi.org/10.1101/741512
Melissa A. Munn-Chernoff
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Emma C. Johnson
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Yi-Ling Chou
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Jonathan R.I. Coleman
3Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, London, UK
4National Institute for Health Research Biomedical Research Centre, King’s College London and South London and Maudsley National Health Service Trust, London, UK
Laura M. Thornton
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Raymond K. Walters
5Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
6Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA
Zeynep Yilmaz
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
7Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Jessica H. Baker
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Christopher Hübel
3Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, London, UK
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Scott Gordon
9QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Sarah E. Medland
9QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Hunna J. Watson
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
10School of Psychology, Curtin University, Perth, Western Australia, Australia
11School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia
Héléna A. Gaspar
3Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, London, UK
4National Institute for Health Research Biomedical Research Centre, King’s College London and South London and Maudsley National Health Service Trust, London, UK
Julien Bryois
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Anke Hinney
12Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Virpi M. Leppä
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Manuel Mattheisen
13Department of Biomedicine, Aarhus University, Aarhus, Denmark
14Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
15Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden
16Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany
Stephan Ripke
5Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
6Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA
17Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany
Shuyang Yao
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Paola Giusti-Rodríguez
7Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Ken B. Hanscombe
18Department of Medical and Molecular Genetics, King’s College London, Guy’s Hospital, London, UK
Roger A.H. Adan
19Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
20Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, The Netherlands
21Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Lars Alfredsson
22Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Tetsuya Ando
23Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
Ole A. Andreassen
24NORMENT Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway
Wade H. Berrettini
25Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
Ilka Boehm
26Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Claudette Boni
27INSERM U894, Centre of Psychiatry and Neuroscience, Paris, France
Vesna Boraska Perica
28Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
29Department of Medical Biology, School of Medicine, University of Split, Split, Croatia
Katharina Buehren
30Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany
Roland Burghardt
31Klinikum Frankfurt/Oder, Frankfurt, Germany
Matteo Cassina
32Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy
Sven Cichon
33Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
34Department of Biomedicine, University of Basel, Basel, Switzerland
35Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany
Maurizio Clementi
32Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy
Roger D. Cone
36Life Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
Philippe Courtet
37Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France
Scott Crow
38Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA
James J. Crowley
7Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
14Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Unna N. Danner
39Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, The Netherlands
Oliver S.P. Davis
40MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
41School of Social and Community Medicine, University of Bristol, Bristol, UK
Martina de Zwaan
42Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany
George Dedoussis
43Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
Daniela Degortes
44Department of Neurosciences, University of Padova, Padova, Italy
Janiece E. DeSocio
45College of Nursing, Seattle University, Seattle, Washington, USA
Danielle M. Dick
46Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
47College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, Virginia, USA
48Department of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
Dimitris Dikeos
49Department of Psychiatry, Athens University Medical School, Athens University, Athens, Greece
Christian Dina
50l’institut du thorax, INSERM, CNRS, Univ Nantes, Nantes, France
Monika Dmitrzak-Weglarz
51Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland
Elisa Docampo
52Barcelona Institute of Science and Technology, Barcelona, Spain
53Universitat Pompeu Fabra, Barcelona, Spain
54Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Laramie E. Duncan
55Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA
Karin Egberts
56Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Centre for Mental Health, Würzburg, Germany
Stefan Ehrlich
26Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Geòrgia Escaramís
52Barcelona Institute of Science and Technology, Barcelona, Spain
53Universitat Pompeu Fabra, Barcelona, Spain
54Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Tõnu Esko
57Estonian Genome Center, University of Tartu, Tartu, Estonia
58Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA
Xavier Estivill
52Barcelona Institute of Science and Technology, Barcelona, Spain
53Universitat Pompeu Fabra, Barcelona, Spain
54Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
59Genomics and Disease, Bioinformatics and Genomics Programme, Centre for Genomic Regulation, Barcelona, Spain
Anne Farmer
3Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, London, UK
Angela Favaro
44Department of Neurosciences, University of Padova, Padova, Italy
Fernando Fernández-Aranda
60Department of Psychiatry, University Hospital of Bellvitge –IDIBELL and CIBERobn, Barcelona, Spain
61Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain
Manfred M. Fichter
62Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany
63Schön Klinik Roseneck affiliated with the Medical Faculty of the University of Munich, Munich, Germany
Krista Fischer
57Estonian Genome Center, University of Tartu, Tartu, Estonia
Manuel Föcker
64Department of Child and Adolescent Psychiatry, University of Münster, Münster, Germany
Lenka Foretova
65Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic
Andreas J. Forstner
34Department of Biomedicine, University of Basel, Basel, Switzerland
66Centre for Human Genetics, University of Marburg, Marburg, Germany
67Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
68Department of Psychiatry (UPK), University of Basel, Basel, Switzerland
Monica Forzan
32Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy
Christopher S. Franklin
28Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
Steven Gallinger
69Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Ina Giegling
70Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
Johanna Giuranna
71Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Fragiskos Gonidakis
721st Psychiatric Department, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece
Philip Gorwood
73INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France
74CMME (GHU Paris Psychiatrie et Neurosciences), Paris Descartes University, Paris, France
Monica Gratacos Mayora
52Barcelona Institute of Science and Technology, Barcelona, Spain
53Universitat Pompeu Fabra, Barcelona, Spain
54Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Sébastien Guillaume
37Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France
Yiran Guo
75Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Hakon Hakonarson
75Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
76Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
Konstantinos Hatzikotoulas
28Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
77Institute of Translational Genomics, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany
Joanna Hauser
78Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Johannes Hebebrand
12Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Sietske G. Helder
3Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, London, UK
79Zorg op Orde, Delft, The Netherlands
Stefan Herms
33Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
34Department of Biomedicine, University of Basel, Basel, Switzerland
Beate Herpertz-Dahlmann
30Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany
Wolfgang Herzog
80Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany
Laura M. Huckins
28Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
81Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA
James I. Hudson
82Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Boston, Massachusetts, USA
Hartmut Imgart
83Eating Disorders Unit, Parklandklinik, Bad Wildungen, Germany
Hidetoshi Inoko
84Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Isehara, Japan
Vladimir Janout
85Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic
Susana Jiménez-Murcia
60Department of Psychiatry, University Hospital of Bellvitge –IDIBELL and CIBERobn, Barcelona, Spain
61Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain
Antonio Julià
86Rheumatology Research Group, Vall d’Hebron Research Institute, Barcelona, Spain
Gursharan Kalsi
3Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, London, UK
Deborah Kaminská
87Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic
Leila Karhunen
88Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
Andreas Karwautz
89Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria
Martien J.H. Kas
19Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
90Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands
James L. Kennedy
91Centre for Addiction and Mental Health, Toronto, Ontario, Canada
92Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
93Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Anna Keski-Rahkonen
94Department of Public Health, University of Helsinki, Helsinki, Finland
Kirsty Kiezebrink
95Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK
Youl-Ri Kim
96Department of Psychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea
Kelly L. Klump
97Department of Psychology, Michigan State University, East Lansing, Michigan, USA
Gun Peggy S. Knudsen
98Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway
Maria C. La Via
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Stephanie Le Hellard
99Department of Clinical Science, Norwegian Centre for Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway
100Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
101Department of Clinical Medicine, Laboratory Building, Haukeland University Hospital, Bergen, Norway
Robert D. Levitan
92Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Dong Li
75Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Lisa Lilenfeld
102The Chicago School of Professional Psychology, Washington DC Campus, USA
Bochao Danae Lin
19Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Jolanta Lissowska
103Department of Cancer Epidemiology and Prevention, M Skłodowska-Curie Cancer Center - Oncology Center, Warsaw, Poland
Jurjen Luykx
19Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Pierre J. Magistretti
104BESE Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
105Department of Psychiatry, University of Lausanne-University Hospital of Lausanne (UNIL-CHUV), Lausanne, Switzerland
Mario Maj
106Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy
Katrin Mannik
57Estonian Genome Center, University of Tartu, Tartu, Estonia
107Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
Sara Marsal
86Rheumatology Research Group, Vall d’Hebron Research Institute, Barcelona, Spain
Christian R. Marshall
108Department of Paediatric Laboratory Medicine, Division of Genome Diagnostics, The Hospital for Sick Children, Toronto, Ontario, Canada
Morten Mattingsdal
109NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway
Sara McDevitt
110Department of Psychiatry, University College Cork, Cork, Ireland
111Eist Linn Adolescent Unit, Bessborough, Health Service Executive South, Cork, Ireland
Peter McGuffin
3Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, London, UK
Andres Metspalu
57Estonian Genome Center, University of Tartu, Tartu, Estonia
112Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Ingrid Meulenbelt
113Molecular Epidemiology Section (Department of Biomedical Datasciences), Leiden University Medical Centre, Leiden, The Netherlands
Nadia Micali
114Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland
115Division of Child and Adolescent Psychiatry, Geneva University Hospital, Geneva, Switzerland
Karen Mitchell
116National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts, USA
117Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
Alessio Maria Monteleone
106Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy
Palmiero Monteleone
118Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Salerno, Italy
Benedetta Nacmias
119Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy
Marie Navratilova
65Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic
Ioanna Ntalla
43Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
Julie K. O’Toole
120Kartini Clinic, Portland, Oregon, USA
Roel A. Ophoff
121Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA
122Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Leonid Padyukov
123Division of Rheumatology, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
Aarno Palotie
58Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA
124Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland
125Center for Human Genome Research, Massachusetts General Hospital, Boston, Massachusetts, USA
Jacques Pantel
27INSERM U894, Centre of Psychiatry and Neuroscience, Paris, France
Hana Papezova
87Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic
Dalila Pinto
81Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Raquel Rabionet
126Saint Joan de Déu Research Institute, Saint Joan de Déu Barcelona Children’s Hospital, Barcelona, Spain
127Institute of Biomedicine (IBUB), University of Barcelona, Barcelona, Spain
128Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain
Anu Raevuori
94Department of Public Health, University of Helsinki, Helsinki, Finland
Nicolas Ramoz
27INSERM U894, Centre of Psychiatry and Neuroscience, Paris, France
Ted Reichborn-Kjennerud
98Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway
129Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Valdo Ricca
130Department of Health Science, University of Florence, Florence, Italy
Samuli Ripatti
131Department of Biometry, University of Helsinki, Helsinki, Finland
Franziska Ritschel
26Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
132Eating Disorders Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Marion Roberts
3Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, London, UK
Alessandro Rotondo
133Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Pisa, Italy
Dan Rujescu
70Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
Filip Rybakowski
134Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Paolo Santonastaso
135Department of Neurosciences, Padua Neuroscience Center, University of Padova, Padova, Italy
André Scherag
136Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany
Stephen W. Scherer
137Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
138McLaughlin Centre, University of Toronto, Toronto, Ontario, Canada
Ulrike Schmidt
139Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King’s College London, London, UK
Nicholas J. Schork
140J. Craig Venter Institute (JCVI), La Jolla, California, USA
Alexandra Schosser
141Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
Jochen Seitz
30Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany
Lenka Slachtova
142Department of Pediatrics and Center of Applied Genomics, First Faculty of Medicine, Charles University, Prague, Czech Republic
P. Eline Slagboom
143Molecular Epidemiology Section (Department of Medical Statistics), Leiden University Medical Centre, Leiden, The Netherlands
Margarita C.T. Slof-Op’t Landt
144Center for Eating Disorders Ursula, Rivierduinen, Leiden, The Netherlands
145Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
Agnieszka Slopien
146Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Sandro Sorbi
119Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy
147IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy
Beata Świątkowska
148Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland
Jin P. Szatkiewicz
7Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Ioanna Tachmazidou
28Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
Elena Tenconi
44Department of Neurosciences, University of Padova, Padova, Italy
Alfonso Tortorella
149Department of Psychiatry, University of Naples SUN, Naples, Italy
150Department of Psychiatry, University of Perugia, Perugia, Italy
Federica Tozzi
151Brain Sciences Department, Stremble Ventures, Limassol, Cyprus
Janet Treasure
139Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King’s College London, London, UK
Artemis Tsitsika
152Adolescent Health Unit, Second Department of Pediatrics, “P. & A. Kyriakou” Children’s Hospital, University of Athens, Athens, Greece
Marta Tyszkiewicz-Nwafor
146Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Konstantinos Tziouvas
153Pediatric Intensive Care Unit, “P. & A. Kyriakou” Children’s Hospital, University of Athens, Athens, Greece
Annemarie A. van Elburg
20Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, The Netherlands
154Faculty of Social and Behavioral Sciences, Utrecht University, Utrecht, The Netherlands
Eric F. van Furth
144Center for Eating Disorders Ursula, Rivierduinen, Leiden, The Netherlands
145Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
Gudrun Wagner
89Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria
Esther Walton
26Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Elisabeth Widen
124Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland
Eleftheria Zeggini
28Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
77Institute of Translational Genomics, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany
Stephanie Zerwas
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Stephan Zipfel
155Department of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tuebingen, Tuebingen, Germany
Andrew W. Bergen
156BioRealm, LLC, Walnut, California, USA
157Oregon Research Institute, Eugene, Oregon, USA
Joseph M. Boden
158Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand
Harry Brandt
159The Center for Eating Disorders at Sheppard Pratt, Baltimore, Maryland, USA
Steven Crawford
159The Center for Eating Disorders at Sheppard Pratt, Baltimore, Maryland, USA
Katherine A. Halmi
160Department of Psychiatry, Weill Cornell Medical College, New York, New York, USA
L. John Horwood
158Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand
Craig Johnson
161Eating Recovery Center, Denver, Colorado, USA
Allan S. Kaplan
91Centre for Addiction and Mental Health, Toronto, Ontario, Canada
92Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
93Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Walter H. Kaye
162Department of Psychiatry, University of California San Diego, La Jolla, California, USA
James Mitchell
163Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USA
Catherine M. Olsen
164Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
John F. Pearson
165Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand
Nancy L. Pedersen
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Michael Strober
166Department of Psychiatry and Biobehavioral Science, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA
167David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
Thomas Werge
168Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
David C. Whiteman
164Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
D. Blake Woodside
92Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
93Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
169Centre for Mental Health, University Health Network, Toronto, Ontario, Canada
170Program for Eating Disorders, University Health Network, Toronto, Ontario, Canada
Jakob Grove
13Department of Biomedicine, Aarhus University, Aarhus, Denmark
171The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark
172Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark
173Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
Anjali K. Henders
174Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
Janne T. Larsen
171The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark
175National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark
176Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark
Richard Parker
9QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Liselotte V. Petersen
171The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark
175National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark
176Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark
Jennifer Jordan
177Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
178Canterbury District Health Board, Christchurch, New Zealand
Martin A. Kennedy
179Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand
Andreas Birgegård
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
14Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
15Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden
Paul Lichtenstein
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Claes Norring
14Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
15Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden
Mikael Landén
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
180Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Preben Bo Mortensen
171The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark
175National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark
176Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark
Renato Polimanti
181Division of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
182Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
Jeanette N. McClintick
183Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Amy E. Adkins
46Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
47College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, Virginia, USA
Fazil Aliev
46Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
Silviu-Alin Bacanu
184Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, Virginia, USA
185Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
186Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Anthony Batzler
187Psychiatric Genomics and Pharmacogenomics Program, Mayo Clinic, Rochester, Minnesota, USA
Sarah Bertelsen
188Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Joanna M. Biernacka
189Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
190Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA
Tim B. Bigdeli
191Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA
Li-Shiun Chen
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Toni-Kim Clarke
192Division of Psychiatry, University of Edinburgh, Edinburgh, UK
Franziska Degenhardt
193Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
Anna R. Docherty
194Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA
Alexis C. Edwards
185Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
186Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Jerome C. Foo
195Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Louis Fox
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Josef Frank
195Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Laura M. Hack
55Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA
Annette M. Hartmann
70Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
Sarah M. Hartz
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Stefanie Heilmann-Heimbach
193Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
Colin Hodgkinson
196Laboratory of Neurogenetics, NIH/NIAAA, Bethesda, Maryland, USA
Per Hoffmann
197Institute of Human Genetics, School of Medicine & University Hospital Bonn, University of Bonn, Bonn, Germany
198Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland
199Institute of Medical Genetics and Pathology, University Hospital Basel, University Hospital Basel, Basel, Switzerland
Jouke-Jan Hottenga
200Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Bettina Konte
70Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
Jari Lahti
201Turku Institute for Advanced Studies, University of Turku, Turku, Finland
Marius Lahti-Pulkkinen
202Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
Dongbing Lai
203Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Lannie Ligthart
200Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Anu Loukola
124Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland
Brion S. Maher
204Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Hamdi Mbarek
200Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Andrew M. McIntosh
205Division of Psychiatry, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
Matthew B. McQueen
206Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA
Jacquelyn L. Meyers
207Department of Psychiatry and Behavioral Sciences, Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, New York, USA
Yuri Milaneschi
208Department of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center/GGz inGeest, Amsterdam, The Netherlands
Teemu Palviainen
124Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland
Roseann E. Peterson
185Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
186Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Euijung Ryu
189Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
Nancy L. Saccone
209Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, USA
Jessica E. Salvatore
46Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
185Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
186Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Sandra Sanchez-Roige
162Department of Psychiatry, University of California San Diego, La Jolla, California, USA
Melanie Schwandt
210NIH/NIAAA, Office of the Clinical Director, Bethesda, Maryland, USA
Richard Sherva
211Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA
Fabian Streit
195Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Jana Strohmaier
195Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Nathaniel Thomas
46Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
47College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, Virginia, USA
Jen-Chyong Wang
188Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Bradley T. Webb
184Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, Virginia, USA
185Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
186Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Robbee Wedow
5Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
6Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA
212Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, Massachusetts, USA
213Department of Sociology, Harvard University, Cambridge, Massachusetts, USA
Leah Wetherill
203Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Amanda G. Wills
214Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA
Hang Zhou
181Division of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
182Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
Jason D. Boardman
215Institute of Behavioral Science, University of Colorado, Boulder, Colorado, USA
216Department of Sociology, University of Colorado, Boulder, Colorado, USA
Danfeng Chen
6Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA
Doo-Sup Choi
217Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA
William E. Copeland
218Department of Psychiatry, University of Vermont Medical Center, Burlington, Vermont, USA
Robert C. Culverhouse
219Department of Medicine, Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri, USA
Norbert Dahmen
220Department of Psychiatry, University of Mainz, Mainz, Germany
Louisa Degenhardt
221National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia
Benjamin W. Domingue
222Stanford University Graduate School of Education, Stanford University, Stanford, California, USA
Mark A. Frye
190Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA
Wolfgang Gäbel
223Department of Psychiatry and Psychotherapy, University of Düsseldorf, Duesseldorf, Germany
Caroline Hayward
224MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
Marcus Ising
225Max-Planck-Institute of Psychiatry, Munich, Germany
Margaret Keyes
226Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA
Falk Kiefer
227Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Gabrielle Koller
228Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
John Kramer
229Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA
Samuel Kuperman
229Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA
Susanne Lucae
225Max-Planck-Institute of Psychiatry, Munich, Germany
Michael T. Lynskey
230Addictions Department, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Wolfgang Maier
231Department of Psychiatry, University of Bonn, Bonn, Germany
Karl Mann
227Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Satu Männistö
232Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland
Bertram Müller-Myhsok
233Department of Statistical Genetics, Max-Planck-Institute of Psychiatry, München, Germany
Alison D. Murray
234Aberdeen Biomedical Imaging Centre, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Foresterhill, Aberdeen, UK
John I. Nurnberger
203Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
235Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
Ulrich Preuss
236Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Herborn, Germany
237Department of Psychiatry and Psychotherapy, Vitos Hospital Herborn, Herborn, Germany
Katri Räikkönen
202Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
Maureen D. Reynolds
238School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Monika Ridinger
239Department of Psychiatry and Psychotherapy, University of Regensburg Psychiatric Health Care Aargau, Regensburg, Germany
Norbert Scherbaum
240LVR-Hospital Essen, Medical Faculty, University of Duisburg-Essen, Essen, Germany
241Department of Addictive Behaviour and Addiction Medicine, Medical Faculty, University of Duisburg-Essen, Essen, Germany
242Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany
Marc A. Schuckit
162Department of Psychiatry, University of California San Diego, La Jolla, California, USA
Michael Soyka
243Medical Park Chiemseeblick in Bernau-Felden, Ludwig-Maximilians-University, Bernau am Chiemsee, Germany
244Psychiatric Hospital, Ludwig-Maximilians-University, Bernau am Chiemsee, Germany
Jens Treutlein
195Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Stephanie H. Witt
195Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Norbert Wodarz
245Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
Peter Zill
246Department of Psychiatry, Psychiatric Hospital, Ludwig-Maximilians-University, Munich, Germany
Daniel E. Adkins
194Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA
247Department of Sociology, University of Utah, Salt Lake City, Utah, USA
Dorret I. Boomsma
200Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Laura J. Bierut
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Sandra A. Brown
162Department of Psychiatry, University of California San Diego, La Jolla, California, USA
248Department of Psychology, University of California San Diego, USA
Kathleen K. Bucholz
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
E. Jane Costello
249Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
Harriet de Wit
250Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA
Nancy Diazgranados
251NIAAA Intramural Research Program, Bethesda, Maryland, USA
Johan G. Eriksson
252Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland
253National Institute for Health and Welfare, Helsinki, Finland
Lindsay A. Farrer
211Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA
254Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
255Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA
256Department of Epidemiology, School of Public Health, Boston University, Boston, Massachusetts, USA
257Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA
Tatiana M. Foroud
203Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Nathan A. Gillespie
185Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
186Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Alison M. Goate
188Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA
David Goldman
196Laboratory of Neurogenetics, NIH/NIAAA, Bethesda, Maryland, USA
258Office of the Clinical Director, NIH/NIAAA, Besthesda, Maryland, USA
Richard A. Grucza
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Dana B. Hancock
259Center for Omics Discovery and Epidemiology, Behavioral Health Research Division, RTI International, Research Triangle Park, North Carolina, USA
Kathleen Mullan Harris
260Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
261Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Victor Hesselbrock
262Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
John K. Hewitt
263Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA
Christian J. Hopfer
264Department of Psychiatry, University of Colorado Denver, Aurora, Colorado, USA
William G. Iacono
226Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA
Eric O. Johnson
259Center for Omics Discovery and Epidemiology, Behavioral Health Research Division, RTI International, Research Triangle Park, North Carolina, USA
265Fellow Program, RTI International, Research Triangle Park, North Carolina, USA
Victor M. Karpyak
190Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA
Kenneth S. Kendler
185Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
186Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Henry R. Kranzler
266Center for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
267VISN 4 MIRECC, Crescenz VAMC, Philadelphia, Pennsylvania, USA
Kenneth Krauter
268Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA
Penelope A. Lind
9QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Matt McGue
226Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA
James MacKillop
269Peter Boris Centre for Addictions Research, McMaster University/St. Joseph’s Healthcare Hamilton, Hamilton, Ontario, Canada
270Michael G. DeGroote Centre for Medicinal Cannabis Research, McMaster University/St. Joseph’s Healthcare Hamilton, Hamilton, Ontario, Canada
Pamela A.F. Madden
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Hermine H. Maes
185Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
Patrik K.E. Magnusson
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Elliot C. Nelson
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Markus M. Nöthen
193Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
Abraham A. Palmer
162Department of Psychiatry, University of California San Diego, La Jolla, California, USA
271Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA
Brenda W.J.H. Penninx
272Department of Psychiatry, Amsterdam UMC, VU University and GGZinGeest, Amsterdam, The Netherlands
Bernice Porjesz
207Department of Psychiatry and Behavioral Sciences, Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, New York, USA
John P. Rice
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Marcella Rietschel
195Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Brien P. Riley
184Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, Virginia, USA
185Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
186Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Richard J. Rose
273Department of Psychological & Brain Sciences, Indiana University Bloomington, Bloomington, Indiana, USA
Pei-Hong Shen
196Laboratory of Neurogenetics, NIH/NIAAA, Bethesda, Maryland, USA
Judy Silberg
185Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
186Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Michael C. Stallings
263Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA
Ralph E. Tarter
274School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Michael M. Vanyukov
274School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Scott Vrieze
226Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA
Tamara L. Wall
162Department of Psychiatry, University of California San Diego, La Jolla, California, USA
John B. Whitfield
9QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Hongyu Zhao
275Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, Connecticut, USA
Benjamin M. Neale
5Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
6Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA
Tracey D. Wade
276School of Psychology, Flinders University, Adelaide, South Australia, Australia
Andrew C. Heath
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Grant W. Montgomery
9QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
174Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
277Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia
Nicholas G. Martin
9QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Patrick F. Sullivan
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
7Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Jaakko Kaprio
94Department of Public Health, University of Helsinki, Helsinki, Finland
124Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland
Gerome Breen
3Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, London, UK
4National Institute for Health Research Biomedical Research Centre, King’s College London and South London and Maudsley National Health Service Trust, London, UK
Joel Gelernter
181Division of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
182Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
278Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA
279Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, USA
Howard J. Edenberg
183Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
203Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Cynthia M. Bulik
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
280Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Arpana Agrawal
2Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Abstract
Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [rg], twin-based=0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge-eating, AN without binge-eating, and a BN factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder (MDD). Total sample sizes per phenotype ranged from ~2,400 to ~537,000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg=0.18; false discovery rate q=0.0006), cannabis initiation and AN (rg=0.23; q<0.0001), and cannabis initiation and AN with binge-eating (rg=0.27; q=0.0016). Conversely, significant negative genetic correlations were observed between three non-diagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge-eating (rgs=-0.19 to −0.23; qs<0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for MDD loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships between these behaviors.
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Posted August 23, 2019.
Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies
Melissa A. Munn-Chernoff, Emma C. Johnson, Yi-Ling Chou, Jonathan R.I. Coleman, Laura M. Thornton, Raymond K. Walters, Zeynep Yilmaz, Jessica H. Baker, Christopher Hübel, Scott Gordon, Sarah E. Medland, Hunna J. Watson, Héléna A. Gaspar, Julien Bryois, Anke Hinney, Virpi M. Leppä, Manuel Mattheisen, Stephan Ripke, Shuyang Yao, Paola Giusti-Rodríguez, Ken B. Hanscombe, Roger A.H. Adan, Lars Alfredsson, Tetsuya Ando, Ole A. Andreassen, Wade H. Berrettini, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Matteo Cassina, Sven Cichon, Maurizio Clementi, Roger D. Cone, Philippe Courtet, Scott Crow, James J. Crowley, Unna N. Danner, Oliver S.P. Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo, Laramie E. Duncan, Karin Egberts, Stefan Ehrlich, Geòrgia Escaramís, Tõnu Esko, Xavier Estivill, Anne Farmer, Angela Favaro, Fernando Fernández-Aranda, Manfred M. Fichter, Krista Fischer, Manuel Föcker, Lenka Foretova, Andreas J. Forstner, Monica Forzan, Christopher S. Franklin, Steven Gallinger, Ina Giegling, Johanna Giuranna, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Sébastien Guillaume, Yiran Guo, Hakon Hakonarson, Konstantinos Hatzikotoulas, Joanna Hauser, Johannes Hebebrand, Sietske G. Helder, Stefan Herms, Beate Herpertz-Dahlmann, Wolfgang Herzog, Laura M. Huckins, James I. Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimir Janout, Susana Jiménez-Murcia, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Leila Karhunen, Andreas Karwautz, Martien J.H. Kas, James L. Kennedy, Anna Keski-Rahkonen, Kirsty Kiezebrink, Youl-Ri Kim, Kelly L. Klump, Gun Peggy S. Knudsen, Maria C. La Via, Stephanie Le Hellard, Robert D. Levitan, Dong Li, Lisa Lilenfeld, Bochao Danae Lin, Jolanta Lissowska, Jurjen Luykx, Pierre J. Magistretti, Mario Maj, Katrin Mannik, Sara Marsal, Christian R. Marshall, Morten Mattingsdal, Sara McDevitt, Peter McGuffin, Andres Metspalu, Ingrid Meulenbelt, Nadia Micali, Karen Mitchell, Alessio Maria Monteleone, Palmiero Monteleone, Benedetta Nacmias, Marie Navratilova, Ioanna Ntalla, Julie K. O’Toole, Roel A. Ophoff, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papezova, Dalila Pinto, Raquel Rabionet, Anu Raevuori, Nicolas Ramoz, Ted Reichborn-Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Alessandro Rotondo, Dan Rujescu, Filip Rybakowski, Paolo Santonastaso, André Scherag, Stephen W. Scherer, Ulrike Schmidt, Nicholas J. Schork, Alexandra Schosser, Jochen Seitz, Lenka Slachtova, P. Eline Slagboom, Margarita C.T. Slof-Op’t Landt, Agnieszka Slopien, Sandro Sorbi, Beata Świątkowska, Jin P. Szatkiewicz, Ioanna Tachmazidou, Elena Tenconi, Alfonso Tortorella, Federica Tozzi, Janet Treasure, Artemis Tsitsika, Marta Tyszkiewicz-Nwafor, Konstantinos Tziouvas, Annemarie A. van Elburg, Eric F. van Furth, Gudrun Wagner, Esther Walton, Elisabeth Widen, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Andrew W. Bergen, Joseph M. Boden, Harry Brandt, Steven Crawford, Katherine A. Halmi, L. John Horwood, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, James Mitchell, Catherine M. Olsen, John F. Pearson, Nancy L. Pedersen, Michael Strober, Thomas Werge, David C. Whiteman, D. Blake Woodside, Jakob Grove, Anjali K. Henders, Janne T. Larsen, Richard Parker, Liselotte V. Petersen, Jennifer Jordan, Martin A. Kennedy, Andreas Birgegård, Paul Lichtenstein, Claes Norring, Mikael Landén, Preben Bo Mortensen, Renato Polimanti, Jeanette N. McClintick, Amy E. Adkins, Fazil Aliev, Silviu-Alin Bacanu, Anthony Batzler, Sarah Bertelsen, Joanna M. Biernacka, Tim B. Bigdeli, Li-Shiun Chen, Toni-Kim Clarke, Franziska Degenhardt, Anna R. Docherty, Alexis C. Edwards, Jerome C. Foo, Louis Fox, Josef Frank, Laura M. Hack, Annette M. Hartmann, Sarah M. Hartz, Stefanie Heilmann-Heimbach, Colin Hodgkinson, Per Hoffmann, Jouke-Jan Hottenga, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Dongbing Lai, Lannie Ligthart, Anu Loukola, Brion S. Maher, Hamdi Mbarek, Andrew M. McIntosh, Matthew B. McQueen, Jacquelyn L. Meyers, Yuri Milaneschi, Teemu Palviainen, Roseann E. Peterson, Euijung Ryu, Nancy L. Saccone, Jessica E. Salvatore, Sandra Sanchez-Roige, Melanie Schwandt, Richard Sherva, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley T. Webb, Robbee Wedow, Leah Wetherill, Amanda G. Wills, Hang Zhou, Jason D. Boardman, Danfeng Chen, Doo-Sup Choi, William E. Copeland, Robert C. Culverhouse, Norbert Dahmen, Louisa Degenhardt, Benjamin W. Domingue, Mark A. Frye, Wolfgang Gäbel, Caroline Hayward, Marcus Ising, Margaret Keyes, Falk Kiefer, Gabrielle Koller, John Kramer, Samuel Kuperman, Susanne Lucae, Michael T. Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Bertram Müller-Myhsok, Alison D. Murray, John I. Nurnberger, Ulrich Preuss, Katri Räikkönen, Maureen D. Reynolds, Monika Ridinger, Norbert Scherbaum, Marc A. Schuckit, Michael Soyka, Jens Treutlein, Stephanie H. Witt, Norbert Wodarz, Peter Zill, Daniel E. Adkins, Dorret I. Boomsma, Laura J. Bierut, Sandra A. Brown, Kathleen K. Bucholz, E. Jane Costello, Harriet de Wit, Nancy Diazgranados, Johan G. Eriksson, Lindsay A. Farrer, Tatiana M. Foroud, Nathan A. Gillespie, Alison M. Goate, David Goldman, Richard A. Grucza, Dana B. Hancock, Kathleen Mullan Harris, Victor Hesselbrock, John K. Hewitt, Christian J. Hopfer, William G. Iacono, Eric O. Johnson, Victor M. Karpyak, Kenneth S. Kendler, Henry R. Kranzler, Kenneth Krauter, Penelope A. Lind, Matt McGue, James MacKillop, Pamela A.F. Madden, Hermine H. Maes, Patrik K.E. Magnusson, Elliot C. Nelson, Markus M. Nöthen, Abraham A. Palmer, Brenda W.J.H. Penninx, Bernice Porjesz, John P. Rice, Marcella Rietschel, Brien P. Riley, Richard J. Rose, Pei-Hong Shen, Judy Silberg, Michael C. Stallings, Ralph E. Tarter, Michael M. Vanyukov, Scott Vrieze, Tamara L. Wall, John B. Whitfield, Hongyu Zhao, Benjamin M. Neale, Tracey D. Wade, Andrew C. Heath, Grant W. Montgomery, Nicholas G. Martin, Patrick F. Sullivan, Jaakko Kaprio, Gerome Breen, Joel Gelernter, Howard J. Edenberg, Cynthia M. Bulik, Arpana Agrawal
bioRxiv 741512; doi: https://doi.org/10.1101/741512
Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies
Melissa A. Munn-Chernoff, Emma C. Johnson, Yi-Ling Chou, Jonathan R.I. Coleman, Laura M. Thornton, Raymond K. Walters, Zeynep Yilmaz, Jessica H. Baker, Christopher Hübel, Scott Gordon, Sarah E. Medland, Hunna J. Watson, Héléna A. Gaspar, Julien Bryois, Anke Hinney, Virpi M. Leppä, Manuel Mattheisen, Stephan Ripke, Shuyang Yao, Paola Giusti-Rodríguez, Ken B. Hanscombe, Roger A.H. Adan, Lars Alfredsson, Tetsuya Ando, Ole A. Andreassen, Wade H. Berrettini, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Matteo Cassina, Sven Cichon, Maurizio Clementi, Roger D. Cone, Philippe Courtet, Scott Crow, James J. Crowley, Unna N. Danner, Oliver S.P. Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo, Laramie E. Duncan, Karin Egberts, Stefan Ehrlich, Geòrgia Escaramís, Tõnu Esko, Xavier Estivill, Anne Farmer, Angela Favaro, Fernando Fernández-Aranda, Manfred M. Fichter, Krista Fischer, Manuel Föcker, Lenka Foretova, Andreas J. Forstner, Monica Forzan, Christopher S. Franklin, Steven Gallinger, Ina Giegling, Johanna Giuranna, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Sébastien Guillaume, Yiran Guo, Hakon Hakonarson, Konstantinos Hatzikotoulas, Joanna Hauser, Johannes Hebebrand, Sietske G. Helder, Stefan Herms, Beate Herpertz-Dahlmann, Wolfgang Herzog, Laura M. Huckins, James I. Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimir Janout, Susana Jiménez-Murcia, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Leila Karhunen, Andreas Karwautz, Martien J.H. Kas, James L. Kennedy, Anna Keski-Rahkonen, Kirsty Kiezebrink, Youl-Ri Kim, Kelly L. Klump, Gun Peggy S. Knudsen, Maria C. La Via, Stephanie Le Hellard, Robert D. Levitan, Dong Li, Lisa Lilenfeld, Bochao Danae Lin, Jolanta Lissowska, Jurjen Luykx, Pierre J. Magistretti, Mario Maj, Katrin Mannik, Sara Marsal, Christian R. Marshall, Morten Mattingsdal, Sara McDevitt, Peter McGuffin, Andres Metspalu, Ingrid Meulenbelt, Nadia Micali, Karen Mitchell, Alessio Maria Monteleone, Palmiero Monteleone, Benedetta Nacmias, Marie Navratilova, Ioanna Ntalla, Julie K. O’Toole, Roel A. Ophoff, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papezova, Dalila Pinto, Raquel Rabionet, Anu Raevuori, Nicolas Ramoz, Ted Reichborn-Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Alessandro Rotondo, Dan Rujescu, Filip Rybakowski, Paolo Santonastaso, André Scherag, Stephen W. Scherer, Ulrike Schmidt, Nicholas J. Schork, Alexandra Schosser, Jochen Seitz, Lenka Slachtova, P. Eline Slagboom, Margarita C.T. Slof-Op’t Landt, Agnieszka Slopien, Sandro Sorbi, Beata Świątkowska, Jin P. Szatkiewicz, Ioanna Tachmazidou, Elena Tenconi, Alfonso Tortorella, Federica Tozzi, Janet Treasure, Artemis Tsitsika, Marta Tyszkiewicz-Nwafor, Konstantinos Tziouvas, Annemarie A. van Elburg, Eric F. van Furth, Gudrun Wagner, Esther Walton, Elisabeth Widen, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Andrew W. Bergen, Joseph M. Boden, Harry Brandt, Steven Crawford, Katherine A. Halmi, L. John Horwood, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, James Mitchell, Catherine M. Olsen, John F. Pearson, Nancy L. Pedersen, Michael Strober, Thomas Werge, David C. Whiteman, D. Blake Woodside, Jakob Grove, Anjali K. Henders, Janne T. Larsen, Richard Parker, Liselotte V. Petersen, Jennifer Jordan, Martin A. Kennedy, Andreas Birgegård, Paul Lichtenstein, Claes Norring, Mikael Landén, Preben Bo Mortensen, Renato Polimanti, Jeanette N. McClintick, Amy E. Adkins, Fazil Aliev, Silviu-Alin Bacanu, Anthony Batzler, Sarah Bertelsen, Joanna M. Biernacka, Tim B. Bigdeli, Li-Shiun Chen, Toni-Kim Clarke, Franziska Degenhardt, Anna R. Docherty, Alexis C. Edwards, Jerome C. Foo, Louis Fox, Josef Frank, Laura M. Hack, Annette M. Hartmann, Sarah M. Hartz, Stefanie Heilmann-Heimbach, Colin Hodgkinson, Per Hoffmann, Jouke-Jan Hottenga, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Dongbing Lai, Lannie Ligthart, Anu Loukola, Brion S. Maher, Hamdi Mbarek, Andrew M. McIntosh, Matthew B. McQueen, Jacquelyn L. Meyers, Yuri Milaneschi, Teemu Palviainen, Roseann E. Peterson, Euijung Ryu, Nancy L. Saccone, Jessica E. Salvatore, Sandra Sanchez-Roige, Melanie Schwandt, Richard Sherva, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley T. Webb, Robbee Wedow, Leah Wetherill, Amanda G. Wills, Hang Zhou, Jason D. Boardman, Danfeng Chen, Doo-Sup Choi, William E. Copeland, Robert C. Culverhouse, Norbert Dahmen, Louisa Degenhardt, Benjamin W. Domingue, Mark A. Frye, Wolfgang Gäbel, Caroline Hayward, Marcus Ising, Margaret Keyes, Falk Kiefer, Gabrielle Koller, John Kramer, Samuel Kuperman, Susanne Lucae, Michael T. Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Bertram Müller-Myhsok, Alison D. Murray, John I. Nurnberger, Ulrich Preuss, Katri Räikkönen, Maureen D. Reynolds, Monika Ridinger, Norbert Scherbaum, Marc A. Schuckit, Michael Soyka, Jens Treutlein, Stephanie H. Witt, Norbert Wodarz, Peter Zill, Daniel E. Adkins, Dorret I. Boomsma, Laura J. Bierut, Sandra A. Brown, Kathleen K. Bucholz, E. Jane Costello, Harriet de Wit, Nancy Diazgranados, Johan G. Eriksson, Lindsay A. Farrer, Tatiana M. Foroud, Nathan A. Gillespie, Alison M. Goate, David Goldman, Richard A. Grucza, Dana B. Hancock, Kathleen Mullan Harris, Victor Hesselbrock, John K. Hewitt, Christian J. Hopfer, William G. Iacono, Eric O. Johnson, Victor M. Karpyak, Kenneth S. Kendler, Henry R. Kranzler, Kenneth Krauter, Penelope A. Lind, Matt McGue, James MacKillop, Pamela A.F. Madden, Hermine H. Maes, Patrik K.E. Magnusson, Elliot C. Nelson, Markus M. Nöthen, Abraham A. Palmer, Brenda W.J.H. Penninx, Bernice Porjesz, John P. Rice, Marcella Rietschel, Brien P. Riley, Richard J. Rose, Pei-Hong Shen, Judy Silberg, Michael C. Stallings, Ralph E. Tarter, Michael M. Vanyukov, Scott Vrieze, Tamara L. Wall, John B. Whitfield, Hongyu Zhao, Benjamin M. Neale, Tracey D. Wade, Andrew C. Heath, Grant W. Montgomery, Nicholas G. Martin, Patrick F. Sullivan, Jaakko Kaprio, Gerome Breen, Joel Gelernter, Howard J. Edenberg, Cynthia M. Bulik, Arpana Agrawal
bioRxiv 741512; doi: https://doi.org/10.1101/741512
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