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A global map of orientation tuning in mouse visual cortex

View ORCID ProfilePaul G. Fahey, Taliah Muhammad, View ORCID ProfileCameron Smith, View ORCID ProfileEmmanouil Froudarakis, Erick Cobos, Jiakun Fu, View ORCID ProfileEdgar Y. Walker, View ORCID ProfileDimitri Yatsenko, View ORCID ProfileFabian H. Sinz, View ORCID ProfileJacob Reimer, View ORCID ProfileAndreas S. Tolias
doi: https://doi.org/10.1101/745323
Paul G. Fahey
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
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Taliah Muhammad
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
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Cameron Smith
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
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Emmanouil Froudarakis
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
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Erick Cobos
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
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Jiakun Fu
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
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Edgar Y. Walker
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
3Institute for Bioinformatics and Medical Informatics, University of Tübingen, Germany
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Dimitri Yatsenko
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
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Fabian H. Sinz
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
3Institute for Bioinformatics and Medical Informatics, University of Tübingen, Germany
4Bernstein Center for Computational Neuroscience, University of Tübingen, Germany Tübingen, Germany
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Jacob Reimer
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
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  • For correspondence: astolias@bcm.edu reimer@bcm.edu
Andreas S. Tolias
1Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, TX, USA
2Department of Neuroscience, Baylor College of Medicine, TX, USA
5Department of Electrical and Computer Engineering, Rice University, TX, USA
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  • For correspondence: astolias@bcm.edu reimer@bcm.edu
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Abstract

In primates and most carnivores, neurons in primary visual cortex are spatially organized by their functional properties. For example, neurons with similar orientation preferences are grouped together in iso-orientation domains that smoothly vary over the cortical sheet. In rodents, on the other hand, neurons with different orientation preferences are thought to be spatially intermingled, a feature which has been termed “salt-and-pepper” organization. The apparent absence of any systematic structure in orientation tuning has been considered a defining feature of the rodent visual system for more than a decade, with broad implications for brain development, visual processing, and comparative neurophysiology. Here, we revisited this question using new techniques for wide-field two-photon calcium imaging that enabled us to collect nearly complete population tuning preferences in layers 2-4 across a large fraction of the mouse visual hierarchy. Examining the orientation tuning of these hundreds of thousands of neurons, we found a global map spanning multiple visual cortical areas in which orientation bias was organized around a single pinwheel centered in V1. This pattern was consistent across animals and cortical depth. The existence of this global organization in rodents has implications for our understanding of visual processing and the principles governing the ontogeny and phylogeny of the visual cortex of mammals.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 23, 2019.
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A global map of orientation tuning in mouse visual cortex
Paul G. Fahey, Taliah Muhammad, Cameron Smith, Emmanouil Froudarakis, Erick Cobos, Jiakun Fu, Edgar Y. Walker, Dimitri Yatsenko, Fabian H. Sinz, Jacob Reimer, Andreas S. Tolias
bioRxiv 745323; doi: https://doi.org/10.1101/745323
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A global map of orientation tuning in mouse visual cortex
Paul G. Fahey, Taliah Muhammad, Cameron Smith, Emmanouil Froudarakis, Erick Cobos, Jiakun Fu, Edgar Y. Walker, Dimitri Yatsenko, Fabian H. Sinz, Jacob Reimer, Andreas S. Tolias
bioRxiv 745323; doi: https://doi.org/10.1101/745323

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