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The fasciola cinereum of the hippocampus is important in the acquisition, but not the retrieval, of visual contextual memory

Seong-Beom Park, Seung-Woo Yoo, Hyun-Suk Jung, Heung-Yeol Lim, Eunsoo Lee, Woong Sun, View ORCID ProfileInah Lee
doi: https://doi.org/10.1101/748301
Seong-Beom Park
Department of Brain and Cognitive Sciences, Seoul National University, Gwanak-ro 1, Shillim-dong, Gwanak-gu Seoul, Korea 08826
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Seung-Woo Yoo
Department of Brain and Cognitive Sciences, Seoul National University, Gwanak-ro 1, Shillim-dong, Gwanak-gu Seoul, Korea 08826
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Hyun-Suk Jung
Department of Brain and Cognitive Sciences, Seoul National University, Gwanak-ro 1, Shillim-dong, Gwanak-gu Seoul, Korea 08826
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Heung-Yeol Lim
Department of Brain and Cognitive Sciences, Seoul National University, Gwanak-ro 1, Shillim-dong, Gwanak-gu Seoul, Korea 08826
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Eunsoo Lee
Department of Anatomy, College of Medicine, Korea University, Anam-dong 5, Seongbuk-gu Seoul, Korea 02841
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Woong Sun
Department of Anatomy, College of Medicine, Korea University, Anam-dong 5, Seongbuk-gu Seoul, Korea 02841
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Inah Lee
Department of Brain and Cognitive Sciences, Seoul National University, Gwanak-ro 1, Shillim-dong, Gwanak-gu Seoul, Korea 08826
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  • ORCID record for Inah Lee
  • For correspondence: inahlee@snu.ac.kr
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Abstract

The fasciola cinereum (FC) is a small subregion of the hippocampus that has been relatively unattended and less known compared with other subregions with respect to anatomical characteristics and functional significance. The lack of a detailed anatomical characterization of the FC has created ambiguity in the literature regarding the definition of FC borders with the CA1 subregion and attribution of cognitive functions to specific subregions of the hippocampus. Here, we show that the anatomical borders of the FC can be clearly defined histologically, and the region itself is characterized by unique anatomical connections and physiological properties. The major output of the FC is to the dentate gyrus (DG) and the FC itself. Firing properties of cells recorded from the FC were different from those in the CA1, and no sign of neurogenesis was detected in the FC. Selective ablation of neurons in the FC, successfully accomplished using colchicine, significantly impaired acquisition of novel visual-contextual memory in rats, without affecting retrieval of familiar visual-contextual memories. Our findings suggest that, given its connections to the DG, the FC may play critical roles in learning novel contextual behavior.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 28, 2019.
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The fasciola cinereum of the hippocampus is important in the acquisition, but not the retrieval, of visual contextual memory
Seong-Beom Park, Seung-Woo Yoo, Hyun-Suk Jung, Heung-Yeol Lim, Eunsoo Lee, Woong Sun, Inah Lee
bioRxiv 748301; doi: https://doi.org/10.1101/748301
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The fasciola cinereum of the hippocampus is important in the acquisition, but not the retrieval, of visual contextual memory
Seong-Beom Park, Seung-Woo Yoo, Hyun-Suk Jung, Heung-Yeol Lim, Eunsoo Lee, Woong Sun, Inah Lee
bioRxiv 748301; doi: https://doi.org/10.1101/748301

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