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Baroreceptor denervation reduces inflammatory status and worsens cardiovascular collapse during systemic inflammation

View ORCID ProfileMateus R. Amorim, Júnia L. de Deus, Camila A. Pereira, Luiz E. V. da Silva, Gabriela S. Borges, Nathanne S. Ferreira, Marcelo E. Batalhão, José Antunes-Rodrigues, Evelin C. Cárnio, Rita C. Tostes, View ORCID ProfileLuiz G. S. Branco
doi: https://doi.org/10.1101/748608
Mateus R. Amorim
1Dental School of Ribeirão Preto, 14040-904, University of São Paulo, São Paulo, Brazil
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  • ORCID record for Mateus R. Amorim
  • For correspondence: branco@forp.usp.br amorimmr@hotmail.com
Júnia L. de Deus
1Dental School of Ribeirão Preto, 14040-904, University of São Paulo, São Paulo, Brazil
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Camila A. Pereira
2Ribeirão Preto Medical School, 14049-900, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
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Luiz E. V. da Silva
2Ribeirão Preto Medical School, 14049-900, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
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Gabriela S. Borges
2Ribeirão Preto Medical School, 14049-900, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
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Nathanne S. Ferreira
2Ribeirão Preto Medical School, 14049-900, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
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Marcelo E. Batalhão
3Nursing School of Ribeirão Preto, 14040-902, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
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José Antunes-Rodrigues
2Ribeirão Preto Medical School, 14049-900, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
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Evelin C. Cárnio
3Nursing School of Ribeirão Preto, 14040-902, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
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Rita C. Tostes
2Ribeirão Preto Medical School, 14049-900, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
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Luiz G. S. Branco
1Dental School of Ribeirão Preto, 14040-904, University of São Paulo, São Paulo, Brazil
2Ribeirão Preto Medical School, 14049-900, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
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  • ORCID record for Luiz G. S. Branco
  • For correspondence: branco@forp.usp.br amorimmr@hotmail.com
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ABSTRACT

Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles. We hypothesized that baroreceptor denervation affects lipopolysaccharide (LPS)-induced systemic inflammation (SI) and hemodynamic collapse in conscious rats, and that these parameters are interconnected. We combine: a) hemodynamic and thermoregulatory recordings after LPS administration at a septic-like dose b) analysis of the cardiovascular complexity, c) evaluation of vascular function in mesenteric resistance vessels, and d) measurements of inflammatory cytokines (plasma and spleen). LPS-induced drop in blood pressure was higher in sino-aortic denervated (SAD) rats. LPS-induced hemodynamic collapse was associated with SAD-dependent autonomic disbalance. LPS-induced vascular dysfunction was not affected by SAD. Surprisingly, SAD blunted LPS-induced surges of plasma and spleen cytokines. These data indicate that sino-aortic afferents are key to alleviate LPS-induced cardiovascular collapse, affecting the autonomic cardiovascular control, without affecting resistance blood vessels. Moreover, baroreflex modulation of the LPS-induced SI and hemodynamic collapse seem not to be interconnected.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted August 29, 2019.
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Baroreceptor denervation reduces inflammatory status and worsens cardiovascular collapse during systemic inflammation
Mateus R. Amorim, Júnia L. de Deus, Camila A. Pereira, Luiz E. V. da Silva, Gabriela S. Borges, Nathanne S. Ferreira, Marcelo E. Batalhão, José Antunes-Rodrigues, Evelin C. Cárnio, Rita C. Tostes, Luiz G. S. Branco
bioRxiv 748608; doi: https://doi.org/10.1101/748608
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Baroreceptor denervation reduces inflammatory status and worsens cardiovascular collapse during systemic inflammation
Mateus R. Amorim, Júnia L. de Deus, Camila A. Pereira, Luiz E. V. da Silva, Gabriela S. Borges, Nathanne S. Ferreira, Marcelo E. Batalhão, José Antunes-Rodrigues, Evelin C. Cárnio, Rita C. Tostes, Luiz G. S. Branco
bioRxiv 748608; doi: https://doi.org/10.1101/748608

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