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- Margaret A Taub1,
- Joshua S Weinstock2,*,
- Kruthika R Iyer3,*,
- Lisa R Yanek4,*,
- Matthew P Conomos5,*,
- Jennifer A Brody6,
- Ali Keramati7,
- Cecelia A Laurie5,
- Marios Arvanitis8,
- Albert V Smith9,
- John Lane10,
- Lewis C Becker4,
- Joshua C Bis6,
- John Blangero11,
- Eugene R Bleecker12,13,
- Esteban G Burchard14,15,
- Juan C Celedon16,
- Yen Pei C Chang17,
- Brian Custer18,19,
- Dawood Darbar20,
- Lisa de las Fuentes21,
- Dawn L DeMeo22,23,
- Barry I Freedman24,
- Melanie E Garrett25,26,
- Mark T Gladwin27,
- Susan R Heckbert28,29,
- Bertha A Hidalgo30,
- Christie Ingram31,
- Marguerite R Irvin32,
- W Craig Johnson33,
- Stefan Kaab34,35,
- Lenore Launer36,
- Jiwon Lee37,
- Simin Liu38,
- Arden Moscati39,
- Kari E North40,
- Patricia A Peyser41,
- Nicholas Rafaels42,
- Laura M Raffield43,
- Daniel E Weeks44,45,
- Marsha M Wheeler46,
- L. Keoki Williams47,
- Wei Zhao48,
- Mary Armanios49,
- Stella Aslibekyan30,
- Paul L Auer50,
- Donald W Bowden51,
- Brian E Cade52,
- Ida Yii-Der Chen53,
- Michael H Cho22,
- L Adrienne Cupples54,55,
- Joanne E Curran56,
- Michelle Daya42,
- Ranjan Deka57,
- Xiuqing Guo53,
- Lifang Hou58,
- Shih-Jen Hwang59,
- Jill M Johnsen60,61,
- Eimear E Kenny62,39,
- Albert M Levin63,
- Chunyu Liu64,65,
- Ryan L Minster44,
- Mehdi Nouraie27,
- Ester C Sabino66,
- Jennifer A Smith48,
- Nicholas L Smith28,29,
- Jessica Lasky Su22,23,
- Marilyn J Telen25,
- Hemant K Tiwari67,
- Russell P Tracy68,
- Marquitta J White69,
- Yingze Zhang27,
- Kerri L Wiggins6,
- Scott T Weiss70,23,
- Ramachandran S Vasan71,72,
- Kent D Taylor53,
- Moritz F Sinner34,35,
- Edwin K Silverman22,
- M. Benjamin Shoemaker73,
- Wayne H-H Sheu74,
- Jerome I Rotter75,
- Susan Redline76,77,
- Bruce M Psaty78,29,
- Juan M Peralta11,
- Nicholette D Palmer51,
- Ruth JF Loos39,79,
- Courtney G Montgomery80,
- Braxton D Mitchell81,82,
- Deborah A Meyers12,13,
- Stephen T McGarvey83,
- Angel CY Mak14,
- Rajesh Kumar84,
- Charles Kooperberg85,
- Barbara A Konkle86,61,
- Shannon Kelly87,88,
- Sharon LR Kardia48,
- Robert Kaplan89,
- Jiang He90,
- Hongsheng Gui47,
- Myriam Fornage91,92,
- Patrick T Ellinor93,
- Mariza de Andrade94,
- Adolfo Correa95,
- Eric Boerwinkle96,
- Kathleen C Barnes42,
- Allison E Ashley-Koch25,26,
- Donna K Arnett97,
- Christine Albert23,98,
- NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium†,
- TOPMed Hematology and Hemostasis Working Group#,
- TOPMed Structural Variation Working Group§,
- Cathy C Laurie5,
- Goncalo Abecasis99,
- Abraham Aviv100,
- Deborah A Nickerson101,
- James G Wilson102,
- Stephen S Rich103,
- Daniel Levy64,65,
- Alexis Battle104,
- Thomas W Blackwell105,106,
- Ingo Ruczinski1,
- Timothy Thornton107,
- Jeff O’Connell108,109,
- James A Perry17,
- Nathan Pankratz10,
- Alexander P Reiner110,85 and
- Rasika A Mathias4,‡
- 1Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA
- 2Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI USA
- 3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA
- 4GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore MD USA
- 5Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA
- 6Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
- 7Department of Cardiology, Johns Hopkins School of Medicine, Baltimore MD USA
- 8Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore MD USA
- 9Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI USA
- 10Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA
- 11Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX USA
- 12Department of Medicine, Division of Genetics, Genomics and Precision Medicine University of Arizona, Tucson, AZ, USA
- 13Division of Pharmacogenomics, University of Arizona, Tucson, AZ, USA
- 14Department of Medicine, University of California San Francisco, San Francisco, USA
- 15Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA
- 16Division of Pediatric Pulmonary Medicine, UPMC Children’s Hospital of Pittsburgh, PIttsburgh, PA, USA
- 17Department of Medicine, University of Maryland School of Medicine, Baltimore, MD;
- 18Vitalant Research Institute, San Francisco, CA, USA
- 19Department of Laboratory Medicine, UCSF, San Francisco, CA, USA
- 20Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA
- 21Cardiovascular Division, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA
- 22Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
- 23Harvard Medical School, Boston, MA, USA
- 24Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine; Winston-Salem, NC, USA
- 25Department of Medicine, Duke University Medical Center, Durham, NC, USA
- 26Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA
- 27Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
- 28Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA
- 29Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
- 30University of Alabama at Birmingham, Birmingham, AL, USA
- 31Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
- 32Dept. of Epidemiology, UAB, Birmingham, AL, USA
- 33Department of Biostatistics, Collaborative Health Studies Coordinating Center, University of Washisngton, Seattle, WA, USA
- 34Department of Medicine I, University Hospital Munich, Ludwig-Maximilian’s University, Munich, Germany
- 35German Centre for Cardiovascular Research (DZHK); partner site: Munich Heart Alliance, Munich, Germany
- 36Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
- 37Department of Medicine, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA, USA
- 38Department of Epidemiology, Brown University, Providence, RI, USA
- 39The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 40Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
- 41Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
- 42Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
- 43Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
- 44Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
- 45Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
- 46Genome Sciences, University of Washington, Seattle, WA, USA
- 47Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA
- 48Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
- 49Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA
- 50Zilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee WI, USA
- 51Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA
- 52Division of Sleep Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
- 53The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
- 54Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
- 55The Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
- 56Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA
- 57Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA
- 58Department of Preventive Medicine, Northwestern University, Chicago, IL, USA
- 59Population Sciences Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institute of Health, Bethesda, MD, USA
- 60Bloodworks Northwest, Research Institute, Seattle, WA, USA and University of Washington, Department of Medicine, Seattle, WA, USA
- 61University of Washington, Department of Medicine, Seattle, WA, USA
- 62Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 63Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA
- 64The National Heart, Lung, and Blood Institute, Boston University’s Framingham Heart Study, Framingham, MA, USA
- 65The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
- 66Instituto de Medicina Tropical da Faculdade de Medicina da Uiversidade de Sao Paulo, Sao Paulo, Brazil
- 67Dept. of Biostatistics, UAB, Birmingham, AL, USA
- 68Departments of Pathology & Laboratory Medicine and Biochemistry, Larrner College of Medicine, University of Vermont, Colchester, VT, USA
- 69Department of Medicine, University of California San Francisco, San Francisco, CA, USA
- 70Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston MA, USA
- 71Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
- 72The Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA;
- 73Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
- 74Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- 75The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
- 76Division of Sleep Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
- 77Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
- 78Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA
- 79The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 80Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
- 81Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
- 82Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD;
- 83Department of Epidemiology & International Health Institute, Brown University School of Public Health, Providence, USA
- 84Division of Allergy and Clinical Immunology, The Ann and Robert H. Lurie Children’s Hospital of Chicago, and Department of Pediatrics Northwestern University, Chicago, IL, USA
- 85Division of Public Health Sciences, Fred Htutchinson Cancer Research Center, Seattle WA, USA
- 86Bloodworks Northwest, Research Institute, Seattle, WA, USA
- 87Vitalant Research Institute, San Francisco, CA;
- 88UCSF Benioff Children’s Hospital, Oakland, CA, USA
- 89Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
- 90Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA
- 91Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA
- 92Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA
- 93Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA;
- 94Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA
- 95Jackson Heart Study and Departments of Medicine and Population Health Science, Jackson, MS, USA
- 96Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX;
- 97College of Public Health, University of Kentucky, Lexington, KY, USA
- 98Division of Cardiovascular, Brigham and Women’s Hospital, Boston, MA;
- 99Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA
- 100Center of Human Development and Aging, Rutgers, New Jersey Medical School, Newark, NJ, USA
- 101Department of Genome Sciences, University of Washington, Seattle, WA, USA
- 102Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MI, USA
- 103Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA
- 104Department of Biomedical Engineering, Whiting School of Engineering, Baltimore, MD, USA
- 105Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA
- 106Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
- 107Department of Biostatistics, University of Washington, Seattle, WA, USA
- 108Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
- 109Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
- 110Department of Epidemiology, University of Washington, Seattle, WA, USA
- ↵‡Address Correspondence to: Rasika A Mathias, ScD, rmathias{at}jhmi.edu, 410-550-2487.
↵* These individuals contributed equally to this work.