Abstract
Alternative splicing is a biological process during gene expression that allows a single gene to code for multiple proteins; however splicing patterns can be altered in some conditions or diseases. Here, we present BANDITS, a R/Bioconductor package to perform differential splicing, at both gene and transcript-level, based on RNA-seq data. BANDITS uses a Bayesian hierarchical structure to explicitly model the variability between samples, and treats the transcript allocation of reads as latent variables. We performed an extensive benchmark across both simulated and experimental RNA-seq datasets, where BANDITS has extremely favourable performance with respect to the competitors considered.
Copyright
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