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Dysfunctional and compensatory brain networks underlying math fluency

Michelle AN La, Debjani Saha, Karen F Berman, Hao Yang Tan
doi: https://doi.org/10.1101/752089
Michelle AN La
1Lieber Institute for Brain Development, Baltimore, MD, US
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Debjani Saha
1Lieber Institute for Brain Development, Baltimore, MD, US
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Karen F Berman
3Clinical and Translational Neuroscience Branch, Section on Integrative Neuroimaging, Psychosis and Cognitive Studies Section, National Institute of Mental Health Intramural Research Program, Bethesda, MD, US
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Hao Yang Tan
1Lieber Institute for Brain Development, Baltimore, MD, US
2Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, US
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  • For correspondence: haoyang.tan@libd.org
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Abstract

Poor math fluency, or timed calculation (TC) performance, is a characteristic of dyscalculia, a common cause of poor educational and occupational outcomes. Here, we examined neural substrates of dysfunctional math fluency and potential compensatory mechanisms. We performed functional MRI scans of participants with divergent performance on an event-related TC paradigm (poor TC, <0.5 accuracy, n=34; vs. controls, accuracy>0.8, n=34). Individuals with poor TC had decreased intraparietal sulcus (IPS) engagement, and decreased IPS-striatal and IPS-prefrontal effective connectivity. We next examined an independent well-performing sample (TC accuracy>0.8, n=100), stratified according to relatively low-versus high-IPS activation during TC. Relatively reduced IPS engagement, or patterns of IPS-related effective connectivity similar to those with poor TC, appeared to be compensated for by increased engagement of effective connectivity involving fusiform gyrus, angular gyrus, inferior frontal gyrus and striatum. Neural connectivity involving high-level visual processing in fusiform gyrus and related ventral cortical networks may be relevant in compensatory function ameliorating aspects of dyscalculia and mathematical difficulty.

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Posted September 02, 2019.
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Dysfunctional and compensatory brain networks underlying math fluency
Michelle AN La, Debjani Saha, Karen F Berman, Hao Yang Tan
bioRxiv 752089; doi: https://doi.org/10.1101/752089
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Dysfunctional and compensatory brain networks underlying math fluency
Michelle AN La, Debjani Saha, Karen F Berman, Hao Yang Tan
bioRxiv 752089; doi: https://doi.org/10.1101/752089

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