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Genomics reveals the origins of ancient specimens

View ORCID ProfileQian Cong, Jinhui Shen, View ORCID ProfileJing Zhang, Wenlin Li, View ORCID ProfileLisa N. Kinch, John V. Calhoun, Andrew D. Warren, View ORCID ProfileNick V. Grishin
doi: https://doi.org/10.1101/752121
Qian Cong
2Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, USA
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Jinhui Shen
2Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, USA
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Jing Zhang
2Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, USA
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Wenlin Li
2Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, USA
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Lisa N. Kinch
1Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9050, USA
2Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, USA
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John V. Calhoun
3McGuire Center for Lepidoptera and Biodiversity, Florida Museum of Natural History, University of Florida, 3215 Hull Rd., UF Cultural Plaza, PO Box 112710, Gainesville, Florida, 32611-2710 USA
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Andrew D. Warren
3McGuire Center for Lepidoptera and Biodiversity, Florida Museum of Natural History, University of Florida, 3215 Hull Rd., UF Cultural Plaza, PO Box 112710, Gainesville, Florida, 32611-2710 USA
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Nick V. Grishin
1Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9050, USA
2Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, USA
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  • For correspondence: grishin@chop.swmed.edu
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Abstract

Centuries of zoological studies amassed billions of specimens in collections worldwide. Genomics of these specimens promises to rejuvenate biodiversity research. The obstacles stem from DNA degradation with specimen age. Overcoming this challenge, we set out to resolve a series of long-standing controversies involving a group of butterflies. We deduced geographical origins of several ancient specimens of uncertain provenance that are at the heart of these debates. Here, genomics tackles one of the greatest problems in zoology: countless old, poorly documented specimens that serve as irreplaceable embodiments of species concepts. The ability to figure out where they were collected will resolve many on-going disputes. More broadly, we show the utility of genomics applied to ancient museum specimens to delineate the boundaries of species and populations, and to hypothesize about genotypic determinants of phenotypic traits.

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Posted September 04, 2019.
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Genomics reveals the origins of ancient specimens
Qian Cong, Jinhui Shen, Jing Zhang, Wenlin Li, Lisa N. Kinch, John V. Calhoun, Andrew D. Warren, Nick V. Grishin
bioRxiv 752121; doi: https://doi.org/10.1101/752121
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Genomics reveals the origins of ancient specimens
Qian Cong, Jinhui Shen, Jing Zhang, Wenlin Li, Lisa N. Kinch, John V. Calhoun, Andrew D. Warren, Nick V. Grishin
bioRxiv 752121; doi: https://doi.org/10.1101/752121

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