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Serotonergic modulation of walking in Drosophila

Clare E. Howard, Chin-Lin Chen, Tanya Tabachnik, Rick Hormigo, Pavan Ramdya, View ORCID ProfileRichard S. Mann
doi: https://doi.org/10.1101/753624
Clare E. Howard
1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA
2Medical Scientist Training Program, Columbia University, New York, NY, USA
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Chin-Lin Chen
3Brain Mind Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
4Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
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Tanya Tabachnik
5Advanced Instrumentation Group, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA
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Rick Hormigo
5Advanced Instrumentation Group, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA
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Pavan Ramdya
3Brain Mind Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
4Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
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Richard S. Mann
1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA
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  • ORCID record for Richard S. Mann
  • For correspondence: rsm10@columbia.edu
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Abstract

To navigate complex environments, animals must generate highly robust, yet flexible, locomotor behaviors. For example, walking speed must be tailored to the needs of a particular environment: Not only must animals choose the correct speed and gait, they must also rapidly adapt to changing conditions, and respond to sudden and surprising new stimuli. Neuromodulators, particularly the small biogenic amine neurotransmitters, allow motor circuits to rapidly alter their output by changing their functional connectivity. Here we show that the serotonergic system in the vinegar fly, Drosophilamelanogaster, can modulate walking speed in a variety of contexts and in response to sudden changes in the environment. These multifaceted roles of serotonin in locomotion are differentially mediated by a family of serotonergic receptors with distinct activities and expression patterns.

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Posted September 05, 2019.
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Serotonergic modulation of walking in Drosophila
Clare E. Howard, Chin-Lin Chen, Tanya Tabachnik, Rick Hormigo, Pavan Ramdya, Richard S. Mann
bioRxiv 753624; doi: https://doi.org/10.1101/753624
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Serotonergic modulation of walking in Drosophila
Clare E. Howard, Chin-Lin Chen, Tanya Tabachnik, Rick Hormigo, Pavan Ramdya, Richard S. Mann
bioRxiv 753624; doi: https://doi.org/10.1101/753624

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