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Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
View ORCID ProfileEddie Cano-Gamez, View ORCID ProfileBlagoje Soskic, View ORCID ProfileTheodoros I. Roumeliotis, Ernest So, View ORCID ProfileDeborah J. Smyth, View ORCID ProfileMarta Baldrighi, David Willé, Nikolina Nakic, Jorge Esparza-Gordillo, Christopher G. C. Larminie, Paola G. Bronson, David F. Tough, Wendy C. Rowan, View ORCID ProfileJyoti S. Choudhary, View ORCID ProfileGosia Trynka
doi: https://doi.org/10.1101/753731
Eddie Cano-Gamez
1Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Blagoje Soskic
1Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Theodoros I. Roumeliotis
3Functional Proteomics, The Institute for Cancer Research, London, SW3 6JB, UK
Ernest So
3Functional Proteomics, The Institute for Cancer Research, London, SW3 6JB, UK
Deborah J. Smyth
1Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Marta Baldrighi
1Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
David Willé
4Biostatistics, GSK Medicines Research Centre, Stevenage, UK, SG1 2NY, UK
Nikolina Nakic
5Functional Genomics, Molecular Science and Technology R&D, GSK Medicines Research Centre, Stevenage, SG1 2NY, UK
Jorge Esparza-Gordillo
6Human Genetics, GSK Medicines Research Centre, Stevenage, UK, SG1 2NY, UK
Christopher G. C. Larminie
6Human Genetics, GSK Medicines Research Centre, Stevenage, UK, SG1 2NY, UK
Paola G. Bronson
7Human Target Validation Core, RED Translational Biology, Biogen, Cambridge, MA, USA
David F. Tough
8Epigenetics RU,Oncology R&D, GSK, Medicines Research Centre, Stevenage SG1 2NY, UK
Wendy C. Rowan
9Novel Human Genetics, GSK R&D, Stevenage SG1 2NY, UK
Jyoti S. Choudhary
3Functional Proteomics, The Institute for Cancer Research, London, SW3 6JB, UK
Gosia Trynka
1Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Article usage
Posted September 04, 2019.
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
Eddie Cano-Gamez, Blagoje Soskic, Theodoros I. Roumeliotis, Ernest So, Deborah J. Smyth, Marta Baldrighi, David Willé, Nikolina Nakic, Jorge Esparza-Gordillo, Christopher G. C. Larminie, Paola G. Bronson, David F. Tough, Wendy C. Rowan, Jyoti S. Choudhary, Gosia Trynka
bioRxiv 753731; doi: https://doi.org/10.1101/753731
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
Eddie Cano-Gamez, Blagoje Soskic, Theodoros I. Roumeliotis, Ernest So, Deborah J. Smyth, Marta Baldrighi, David Willé, Nikolina Nakic, Jorge Esparza-Gordillo, Christopher G. C. Larminie, Paola G. Bronson, David F. Tough, Wendy C. Rowan, Jyoti S. Choudhary, Gosia Trynka
bioRxiv 753731; doi: https://doi.org/10.1101/753731
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