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Derivation of endometrial gland organoids from term post-partum placenta

Mirna Marinić, View ORCID ProfileVincent J. Lynch
doi: https://doi.org/10.1101/753780
Mirna Marinić
Department of Organismal Biology and Anatomy, University of Chicago, 1025 E 57th Street, Chicago, IL, 60637, USA
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  • For correspondence: marinic@uchicago.edu vjlynch@buffalo.edu
Vincent J. Lynch
Department of Biological Sciences, University at Buffalo, SUNY, 551 Cooke Hall, Buffalo, NY, 14260, USA
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  • ORCID record for Vincent J. Lynch
  • For correspondence: marinic@uchicago.edu vjlynch@buffalo.edu
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ABSTRACT

A major limitation of recently developed methods for the generation of endometrial gland organoids is their reliance on decidua isolated from endometrial biopsies or elective termination of pregnancies. Here we report the successful establishment of endometrial gland organoids from decidua isolated from term placental membranes, as well as the identification of potential survival factors for the co-culture of gland organoids and endometrial stromal fibroblasts. These modifications facilitate the generation of patient-specific endometrial gland organoids with known pregnancy outcomes, such as term vs. preterm birth.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted August 31, 2019.
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Derivation of endometrial gland organoids from term post-partum placenta
Mirna Marinić, Vincent J. Lynch
bioRxiv 753780; doi: https://doi.org/10.1101/753780
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Derivation of endometrial gland organoids from term post-partum placenta
Mirna Marinić, Vincent J. Lynch
bioRxiv 753780; doi: https://doi.org/10.1101/753780

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