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JUUL and Combusted Cigarettes Comparably Impair Endothelial Function

Poonam Rao, Jiangtao Liu, View ORCID ProfileMatthew L. Springer
doi: https://doi.org/10.1101/754069
Poonam Rao
Division of Cardiology, University of California, San Francisco, San Francisco, California
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Jiangtao Liu
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California
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Matthew L. Springer
Division of Cardiology, University of California, San Francisco, San Francisco, CaliforniaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CaliforniaCenter for Tobacco Control Research and Education, University of California, San Francisco, San Francisco, California
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  • For correspondence: matt.springer@ucsf.edu
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ABSTRACT

Objectives JUUL and earlier generation electronic cigarettes (e-cigs) are promoted as being less hazardous than cigarettes. While JUUL Labs, in particular, claims that switching from smoking to vaping has beneficial impacts, the health effects of such products are not well understood. We investigated whether exposure to JUUL and previous generation e-cig aerosol impairs endothelial function comparably to cigarette smoke.

Methods We exposed rats to aerosol from Virginia Tobacco flavor JUUL, an e-cig tank system using unflavored freebase nicotine e-liquid, Marlboro Red combustible tobacco cigarettes, or clean air for 10 cycles of 2 second inhalation over 5 minutes. Endothelial function (FMD) was measured pre- and post-exposure. Blood was collected 20 mins post-exposure for serum nicotine analysis.

Results Aerosol/smoke from JUUL, previous generation e-cigs, and cigarettes all impaired FMD. The extent of impairment ranged from 34%-58%, although the differences between groups were insignificant. Nicotine was highest in serum from the JUUL group; for the other e-cig and cigarette groups, nicotine levels were lower and comparable to each other.

Conclusions Aerosol from JUUL and previous generation e-cigs impairs endothelial function in rats, comparable to impairment by cigarette smoke.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 02, 2019.
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JUUL and Combusted Cigarettes Comparably Impair Endothelial Function
Poonam Rao, Jiangtao Liu, Matthew L. Springer
bioRxiv 754069; doi: https://doi.org/10.1101/754069
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JUUL and Combusted Cigarettes Comparably Impair Endothelial Function
Poonam Rao, Jiangtao Liu, Matthew L. Springer
bioRxiv 754069; doi: https://doi.org/10.1101/754069

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