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Developmental function and state transitions of a gene expression oscillator in C. elegans

Milou W.M. Meeuse, Yannick P. Hauser, Gert-Jan Hendriks, Jan Eglinger, Guy Bogaarts, Charisios Tsiairis, View ORCID ProfileHelge Großhans
doi: https://doi.org/10.1101/755421
Milou W.M. Meeuse
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel
2University of Basel, Petersplatz 1, CH-4001 Basel
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Yannick P. Hauser
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel
2University of Basel, Petersplatz 1, CH-4001 Basel
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Gert-Jan Hendriks
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel
2University of Basel, Petersplatz 1, CH-4001 Basel
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Jan Eglinger
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel
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Guy Bogaarts
3University Hospital, Spitalstrasse 21, CH-4031 Basel
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Charisios Tsiairis
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel
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Helge Großhans
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel
2University of Basel, Petersplatz 1, CH-4001 Basel
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  • ORCID record for Helge Großhans
  • For correspondence: helge.grosshans@fmi.ch
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Abstract

Gene expression oscillators can structure biological events temporally and spatially. Different biological functions benefit from distinct oscillator properties. Thus, finite developmental processes rely on oscillators that start and stop at specific times; a poorly understood behavior. Here, we have characterized a massive gene expression oscillator comprising >3,700 genes in C. elegans larvae. We report that oscillations initiate in embryos, arrest transiently after hatching and in response to perturbation, and cease in adults. Experimental observation of the transitions between oscillatory and non-oscillatory states at a resolution where we can identify bifurcation points reveals an oscillator operating near a Saddle Node on Invariant Cycle (SNIC) bifurcation. These findings constrain the architecture and mathematical models that can represent this oscillator. They also reveal that oscillator arrests occur reproducibly in a specific phase. Since we find oscillations to be coupled to developmental processes, including molting, this characteristic of SNIC bifurcations thus endows the oscillator with the potential to halt larval development at defined intervals, and thereby execute a developmental checkpoint function.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 18, 2020.
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Developmental function and state transitions of a gene expression oscillator in C. elegans
Milou W.M. Meeuse, Yannick P. Hauser, Gert-Jan Hendriks, Jan Eglinger, Guy Bogaarts, Charisios Tsiairis, Helge Großhans
bioRxiv 755421; doi: https://doi.org/10.1101/755421
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Developmental function and state transitions of a gene expression oscillator in C. elegans
Milou W.M. Meeuse, Yannick P. Hauser, Gert-Jan Hendriks, Jan Eglinger, Guy Bogaarts, Charisios Tsiairis, Helge Großhans
bioRxiv 755421; doi: https://doi.org/10.1101/755421

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