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Context-dependent decision making in a premotor circuit

Zheng Wu, View ORCID ProfileAshok Litwin-Kumar, View ORCID ProfilePhilip Shamash, Alexei Taylor, Richard Axel, Michael N. Shadlen
doi: https://doi.org/10.1101/757104
Zheng Wu
Howard Hughes Medical Institute, Columbia University, New York, NY 10027, USA.Mortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia University, New York, NY 10027, USA.
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Ashok Litwin-Kumar
Mortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia University, New York, NY 10027, USA.
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  • ORCID record for Ashok Litwin-Kumar
Philip Shamash
Mortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia University, New York, NY 10027, USA.Sainsbury Wellcome Centre, University College London (UCL), London, UK.
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Alexei Taylor
Howard Hughes Medical Institute, Columbia University, New York, NY 10027, USA.Mortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia University, New York, NY 10027, USA.
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Richard Axel
Howard Hughes Medical Institute, Columbia University, New York, NY 10027, USA.Mortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia University, New York, NY 10027, USA.
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  • For correspondence: ra27@columbia.edu shadlen@columbia.edu
Michael N. Shadlen
Howard Hughes Medical Institute, Columbia University, New York, NY 10027, USA.Mortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia University, New York, NY 10027, USA.
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  • For correspondence: ra27@columbia.edu shadlen@columbia.edu
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Summary

Cognitive capacities afford contingent associations between sensory information and behavioral responses. We studied this problem using an olfactory delayed match to sample task whereby a sample odor specifies the association between a subsequent test odor and rewarding action. Multi-neuron recordings revealed representations of the sample and test odors in olfactory sensory and association cortex, which were sufficient to identify the test odor as match/non-match. Yet, inactivation of a downstream premotor area (ALM), but not orbitofrontal cortex, confined to the epoch preceding the test odor, led to gross impairment. Olfactory decisions that were not context dependent were unimpaired. Therefore, ALM may not receive the outcome of a match/non-match decision from upstream areas but contextual information—the identity of the sample—to establish the mapping between test odor and action. A novel population of pyramidal neurons in ALM layer 2 may mediate this process.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 03, 2019.
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Context-dependent decision making in a premotor circuit
Zheng Wu, Ashok Litwin-Kumar, Philip Shamash, Alexei Taylor, Richard Axel, Michael N. Shadlen
bioRxiv 757104; doi: https://doi.org/10.1101/757104
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Context-dependent decision making in a premotor circuit
Zheng Wu, Ashok Litwin-Kumar, Philip Shamash, Alexei Taylor, Richard Axel, Michael N. Shadlen
bioRxiv 757104; doi: https://doi.org/10.1101/757104

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