Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring

Oswaldo A. Lozoya; Fuhua Xu; Dagoberto Grenet; Tianyuan Wang; Sara A. Grimm; Veronica G. Godfrey; Suramya Waidyanatha; Richard P. Woychik; Janine H. Santos

doi:10.1101/758474

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Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring

View ORCID ProfileOswaldo A. Lozoya, Fuhua Xu, Dagoberto Grenet, Tianyuan Wang, Sara A. Grimm, Veronica G. Godfrey, Suramya Waidyanatha, Richard P. Woychik, Janine H. Santos

doi: https://doi.org/10.1101/758474

Oswaldo A. Lozoya

Genome Integrity and Structural Biology Laboratory, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC, 27709

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ORCID record for Oswaldo A. Lozoya

Fuhua Xu

Genome Integrity and Structural Biology Laboratory, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC, 27709

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Dagoberto Grenet

Genome Integrity and Structural Biology Laboratory, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC, 27709

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Tianyuan Wang

Integrative Bioinformatics Support Group, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC, 27709

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Sara A. Grimm

Integrative Bioinformatics Support Group, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC, 27709

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Veronica G. Godfrey

National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC, 27709

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Suramya Waidyanatha

National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC, 27709

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Richard P. Woychik

Genome Integrity and Structural Biology Laboratory, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC, 27709

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For correspondence: janine.santos@nih.gov rick.woychik@nih.gov

Janine H. Santos

Genome Integrity and Structural Biology Laboratory, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC, 27709

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For correspondence: janine.santos@nih.gov rick.woychik@nih.gov

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Posted September 10, 2019.

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Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring

Oswaldo A. Lozoya, Fuhua Xu, Dagoberto Grenet, Tianyuan Wang, Sara A. Grimm, Veronica G. Godfrey, Suramya Waidyanatha, Richard P. Woychik, Janine H. Santos

bioRxiv 758474; doi: https://doi.org/10.1101/758474

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Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring

Oswaldo A. Lozoya, Fuhua Xu, Dagoberto Grenet, Tianyuan Wang, Sara A. Grimm, Veronica G. Godfrey, Suramya Waidyanatha, Richard P. Woychik, Janine H. Santos

bioRxiv 758474; doi: https://doi.org/10.1101/758474

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