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Widespread Receptor Driven Modulation in Peripheral Olfactory Coding

Lu Xu, Wenze Li, Venkatakaushik Voleti, View ORCID ProfileElizabeth M. C. Hillman, View ORCID ProfileStuart Firestein
doi: https://doi.org/10.1101/760330
Lu Xu
1Department of Biological Sciences, Columbia University in the City of New York, New York, New York, 10027, USA
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Wenze Li
2Laboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Sciences, Columbia University in the City of New York, New York, New York, 10027, USA
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Venkatakaushik Voleti
2Laboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Sciences, Columbia University in the City of New York, New York, New York, 10027, USA
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Elizabeth M. C. Hillman
2Laboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Sciences, Columbia University in the City of New York, New York, New York, 10027, USA
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  • For correspondence: sjf24@columbia.edu eh2245@columbia.edu
Stuart Firestein
1Department of Biological Sciences, Columbia University in the City of New York, New York, New York, 10027, USA
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  • ORCID record for Stuart Firestein
  • For correspondence: sjf24@columbia.edu eh2245@columbia.edu
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Abstract

We utilized swept confocally aligned planar excitation (SCAPE) microscopy to measure odor-driven activity simultaneously in many (>10,000) olfactory sensory neurons distributed over large areas of intact mouse olfactory epithelium. This approach allowed us to investigate the responses to mixtures or blends of odors and their components, a more realistic stimulus than monomolecular odors. In up to 38% of responding cells, responses to a mixture of odors were different - absent, smaller or larger - than what would be expected from the sum of the individual components. Further investigation revealed instances of both antagonism and allosteric enhancement in the primary olfactory sensory neurons. All 10 of the odor compounds tested were found to act as both agonists and antagonists at different receptors. We present a hypothetical scheme for how modulation at the peripheral receptors increases the capability of the olfactory system to recognize patterns of complex odor mixtures. The widespread modulation of primary sensory receptors argues against a simple combinatorial code and should motivate a search for alternative coding strategies.

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Posted September 08, 2019.
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Widespread Receptor Driven Modulation in Peripheral Olfactory Coding
Lu Xu, Wenze Li, Venkatakaushik Voleti, Elizabeth M. C. Hillman, Stuart Firestein
bioRxiv 760330; doi: https://doi.org/10.1101/760330
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Widespread Receptor Driven Modulation in Peripheral Olfactory Coding
Lu Xu, Wenze Li, Venkatakaushik Voleti, Elizabeth M. C. Hillman, Stuart Firestein
bioRxiv 760330; doi: https://doi.org/10.1101/760330

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