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Design principles of a minimal auxin response system

Hirotaka Kato, Sumanth K. Mutte, Hidemasa Suzuki, Isidro Crespo, Shubhajit Das, Tatyana Radoeva, Mattia Fontana, Yoshihiro Yoshitake, Emi Hainiwa, Willy van den Berg, Simon Lindhoud, Johannes Hohlbein, Jan Willem Borst, D. Roeland Boer, Ryuichi Nishihama, Takayuki Kohchi, Dolf Weijers
doi: https://doi.org/10.1101/760876
Hirotaka Kato
1Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
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Sumanth K. Mutte
1Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
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Hidemasa Suzuki
2Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan
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Isidro Crespo
3Alba Synchrotron, Cerdanyola del Vallès, Barcelona, Spain
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Shubhajit Das
1Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
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Tatyana Radoeva
1Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
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Mattia Fontana
1Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
4Laboratory of Biophysics, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
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Yoshihiro Yoshitake
2Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan
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Emi Hainiwa
2Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan
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Willy van den Berg
1Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
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Simon Lindhoud
1Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
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Johannes Hohlbein
4Laboratory of Biophysics, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
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Jan Willem Borst
1Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
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D. Roeland Boer
3Alba Synchrotron, Cerdanyola del Vallès, Barcelona, Spain
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Ryuichi Nishihama
2Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan
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Takayuki Kohchi
2Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan
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Dolf Weijers
1Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands
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  • For correspondence: dolf.weijers@wur.nl
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Abstract

Auxin controls numerous growth processes in land plants through a gene expression system that modulates ARF transcription factor activity1–3. Gene duplications in families encoding auxin response components have generated tremendous complexity in most land plants, and neofunctionalization enabled various unique response outputs during development2–4. However, it is unclear what fundamental biochemical principles underlie this complex response system. By studying the minimal system in Marchantia polymorpha, we derive an intuitive and simple model where a single auxin-dependent A-ARF activates gene expression. It is antagonized by an auxin-independent B-ARF that represses common target genes. Expression patterns of both ARF proteins define developmental zones where auxin response is permitted, quantitatively tuned, or prevented. This fundamental design likely represents the ancestral system, and formed the basis for inflated, complex systems.

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  • http://www.ncbi.nlm.nih.gov/bioproject/554398

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted September 08, 2019.
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Design principles of a minimal auxin response system
Hirotaka Kato, Sumanth K. Mutte, Hidemasa Suzuki, Isidro Crespo, Shubhajit Das, Tatyana Radoeva, Mattia Fontana, Yoshihiro Yoshitake, Emi Hainiwa, Willy van den Berg, Simon Lindhoud, Johannes Hohlbein, Jan Willem Borst, D. Roeland Boer, Ryuichi Nishihama, Takayuki Kohchi, Dolf Weijers
bioRxiv 760876; doi: https://doi.org/10.1101/760876
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Design principles of a minimal auxin response system
Hirotaka Kato, Sumanth K. Mutte, Hidemasa Suzuki, Isidro Crespo, Shubhajit Das, Tatyana Radoeva, Mattia Fontana, Yoshihiro Yoshitake, Emi Hainiwa, Willy van den Berg, Simon Lindhoud, Johannes Hohlbein, Jan Willem Borst, D. Roeland Boer, Ryuichi Nishihama, Takayuki Kohchi, Dolf Weijers
bioRxiv 760876; doi: https://doi.org/10.1101/760876

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