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Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells
View ORCID ProfileLuca Gerosa, View ORCID ProfileChristopher Chidley, View ORCID ProfileFabian Froehlich, Gabriela Sanchez, Sang Kyun Lim, View ORCID ProfileJeremy Muhlich, Jia-Yun Chen, View ORCID ProfileGregory J. Baker, View ORCID ProfileDenis Schapiro, Tujin Shi, Lian Yi, Carrie D. Nicora, Allison Claas, View ORCID ProfileDouglas A. Lauffenburger, View ORCID ProfileWei-Jun Qian, View ORCID ProfileH. Steven Wiley, View ORCID ProfilePeter K. Sorger
doi: https://doi.org/10.1101/762294
Luca Gerosa
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Christopher Chidley
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Fabian Froehlich
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Gabriela Sanchez
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Sang Kyun Lim
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Jeremy Muhlich
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Jia-Yun Chen
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Gregory J. Baker
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Denis Schapiro
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
Tujin Shi
3Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
Lian Yi
3Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
Carrie D. Nicora
3Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
Allison Claas
4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Douglas A. Lauffenburger
4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Wei-Jun Qian
3Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
H. Steven Wiley
5Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA
Peter K. Sorger
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Posted September 08, 2019.
Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells
Luca Gerosa, Christopher Chidley, Fabian Froehlich, Gabriela Sanchez, Sang Kyun Lim, Jeremy Muhlich, Jia-Yun Chen, Gregory J. Baker, Denis Schapiro, Tujin Shi, Lian Yi, Carrie D. Nicora, Allison Claas, Douglas A. Lauffenburger, Wei-Jun Qian, H. Steven Wiley, Peter K. Sorger
bioRxiv 762294; doi: https://doi.org/10.1101/762294
Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells
Luca Gerosa, Christopher Chidley, Fabian Froehlich, Gabriela Sanchez, Sang Kyun Lim, Jeremy Muhlich, Jia-Yun Chen, Gregory J. Baker, Denis Schapiro, Tujin Shi, Lian Yi, Carrie D. Nicora, Allison Claas, Douglas A. Lauffenburger, Wei-Jun Qian, H. Steven Wiley, Peter K. Sorger
bioRxiv 762294; doi: https://doi.org/10.1101/762294
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